Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) ELISA Kits

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (73) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
SMPD1 308909  
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Top Sphingomyelin phosphodiesterase 1, Acid Lysosomal ELISA Kits at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.31 ng/mL 1.25-80 ng/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$1,026.67
Details
Mouse 0.312-20 ng/mL   96 Tests Log in to see 2 to 3 Days
$713.90
Details
Rabbit 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Guinea Pig 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Rat 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Pig 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Chicken 4.688 ng/mL 7.813-500 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 0.188 ng/mL 0.313-20 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Dog 0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Cow 0.1 ng/mL 5.0-100 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced Sphingomyelin phosphodiesterase 1, Acid Lysosomal ELISA Kits

  1. Human SMPD1 ELISA Kit for Sandwich ELISA - ABIN365016 : Zhu, Yoshimoto, Yamashima: Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase. in The Journal of biological chemistry 2014 (PubMed)

More ELISA Kits for Sphingomyelin phosphodiesterase 1, Acid Lysosomal Interaction Partners

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. This study identified association between Leu-Ala (Val) repeat variants in SMPD1 and Chinese Han patients with sporadic Parkinson's disease.

  2. Parkinson's disease is associated with mutations in SMPD1 gene in Ashkenazi Jews.

  3. Through genetic analysis it was determined that genetic variants in SMPD1 increase the risk of Parkinson's Disease in the Chinese Han population.

  4. Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (show GALC ELISA Kits)), glucocerebrosidase (GBA (show GBA ELISA Kits)), alpha-galactosidase A (GLA (show GLA ELISA Kits)), alpha-iduronidase (IDUA (show IDUA ELISA Kits)) and sphingomyeline phosphodiesterase-1 (SMPD-1)) were measured on ~43,000 de-identified dried blood spot (DBS (show MCF2L ELISA Kits)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk

  5. This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder

  6. stress-induced activation of p38 MAPK (show MAPK14 ELISA Kits) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase/ceramide and p38 MAPK (show MAPK14 ELISA Kits) pathways.

  7. Elevated acid sphingomyelinase (ASM) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).

  8. this is the largest study on mutation analysis of patients with ASM-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 gene mutation spectrum in India.

  9. ASM and ceramides, together with STX6 (show STX6 ELISA Kits) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.

  10. the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. Genetic ablation or pharmacological inhibition of Smpd1 reduced joint swelling and levels of pro-inflammatory cytokines in the arthritic joint.

  2. The results show that mice lacking acid sphingomyelinase had a significant increase in myelin recovery and a significantly higher oligodendrocyte cell count after 2 weeks remyelination compared to wildtype littermates.

  3. These findings suggest that the paradoxical antidepressant effects of alcohol in depressed organisms are mediated by ASM and its control of sphingolipid homeostasis

  4. this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity

  5. K8/K18 (show KRT18 ELISA Kits)-dependent PKCdelta (show PKCd ELISA Kits)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 ELISA Kits) loss.

  6. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.

  7. Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.

  8. this study shows decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice

  9. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP ELISA Kits) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 ELISA Kits) acts downstream from P-selectin (show SELP ELISA Kits) and is necessary for the secretion of Asm.

  10. Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SMPD1

  • sphingomyelin phosphodiesterase 1 (SMPD1) antibody
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1) antibody
  • sphingomyelin phosphodiesterase (LOC5578088) antibody
  • sphingomyelin phosphodiesterase 1 (Smpd1) antibody
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) antibody
  • A-SMase antibody
  • ASM antibody
  • aSMase antibody
  • NPD antibody
  • SMPD1 antibody
  • Zn-SMase antibody

Protein level used designations for SMPD1

acid sphingomyelinase , sphingomyelin phosphodiesterase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , aSMase , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like

GENE ID SPECIES
6609 Homo sapiens
20597 Mus musculus
485334 Canis lupus familiaris
5578088 Aedes aegypti
308909 Rattus norvegicus
450990 Pan troglodytes
505097 Bos taurus
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
100720041 Cavia porcellus
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