anti-Squalene Epoxidase (SQLE) Antibodies

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. Additionally we are shipping Squalene Epoxidase Kits (10) and Squalene Epoxidase Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SQLE 6713 Q14534
SQLE 20775 P52019
SQLE 29230 P52020
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Top anti-Squalene Epoxidase Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SQLE Antibody Titration: 0.25ug/mlPositive Control: 721_B cell lysate SQLE is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in human testis tissue (Formalin-fixed, Paraffin-embedded) using Squalene epoxidase / SQLE Antibody (N-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SQLE antibody for IHC; Clinical relevance has not been evaluated. Western blot analysis in A549 cell line lysates (35ug/lane) using Squalene epoxidase / SQLE Antibody (N-term). This demonstrates the SQLE antibody detected the SQLE protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB SQLE Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SQLE antibody detected the SQLE protein (arrow). SQLE Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SQLE Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB ABIN6272907 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of A549 cells, using SQLE antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Squalene EpoxidasePolyclonal Antibody, Unconjugated (ABIN705401) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated IHC, WB SQLE antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Hepatocytes (arrows) in Human Liver. Magnification is at 400X SQLE antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using SQLE antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated IHC, WB 100 μL 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated WB Western Blot analysis of SQLE expression in transfected 293T cell line by SQLE MaxPab polyclonal antibody.Lane 1: SQLE transfected lysate(63.90 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL 2 to 3 Days
$446.88
Details

Top referenced anti-Squalene Epoxidase Antibodies

  1. Human Polyclonal SQLE Primary Antibody for WB - ABIN948500 : Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. in Human pathology 2013 (PubMed)

  2. Human Polyclonal SQLE Primary Antibody for IHC, IHC (p) - ABIN4355785 : Nguyen, Barozzi, Faronato, Lombardo, Steel, Patel, Darbre, Castellano, Győrffy, Woodley, Meira, Patten, Vircillo, Periyasamy, Ali, Frige, Minucci, Coombes, Magnani: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. in Nature communications 2015 (PubMed)

More Antibodies against Squalene Epoxidase Interaction Partners

Human Squalene Epoxidase (SQLE) interaction partners

  1. Increasingly growing evidence underlines the positive correlation between SE over-expression and poor prognosis in different malignances. SE promotes tumor cell proliferation and migration via many pathways suggesting its oncogenic role. [review]

  2. The shape of squalene epoxidase expands the arsenal against cancer. Review.

  3. Taken together, our results support a model whereby the amphipathic helix in squalene monooxygenase N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal.

  4. Both HMGCR and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 homodimer.

  5. Higher Gleason grade was associated with lower LDLR expression, lower SOAT1 and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 expression (odds ratio, 0.41; 95% CI 0.21-0.83).

  6. Data indicate that microRNA miR-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).

  7. our results pinpoint SQLE as a bona fide metabolic oncogene by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.

  8. this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.

  9. overexpression of SQLE in HCC cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.

  10. Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (membrane-associated ring finger [C3HC4] 6).

  11. MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.

  12. functional promotor regions involved in transcription was determined

  13. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1.

  14. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox analysis in two independent patient cohorts of 160 patients each

Mouse (Murine) Squalene Epoxidase (SQLE) interaction partners

  1. Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.

  2. results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.

  3. Requires a redox partner, but cytochrome p450 reductase is not the only microsomal reductase that will serve this purpose.

Squalene Epoxidase (SQLE) Antigen Profile

Protein Summary

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.

Gene names and symbols associated with SQLE

  • squalene epoxidase (SQLE) antibody
  • squalene epoxidase (ANI_1_450034) antibody
  • squalene epoxidase (AOR_1_1218114) antibody
  • squalene epoxidase (CC1G_03987) antibody
  • squalene epoxidase (BDBG_08449) antibody
  • squalene epoxidase (MCYG_02365) antibody
  • squalene epoxidase (TERG_05717) antibody
  • squalene epoxidase (Sqle) antibody
  • AI323792 antibody
  • An03g03770 antibody
  • AO090701000685 antibody

Protein level used designations for SQLE

squalene epoxidase , squalene monooxygenase , SE

GENE ID SPECIES
100067615 Equus caballus
4980366 Aspergillus niger CBS 513.88
5995549 Aspergillus oryzae RIB40
6007557 Coprinopsis cinerea okayama7130
8508601 Ajellomyces dermatitidis SLH14081
9226506 Arthroderma otae CBS 113480
10376061 Trichophyton rubrum CBS 118892
100125351 Ovis aries
6713 Homo sapiens
608021 Canis lupus familiaris
100113409 Sus scrofa
526535 Bos taurus
20775 Mus musculus
29230 Rattus norvegicus
420335 Gallus gallus
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