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Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. Additionally we are shipping Squalene Epoxidase Kits (8) and Squalene Epoxidase Proteins (4) and many more products for this protein.
Showing 10 out of 28 products:
Human Polyclonal SQLE Primary Antibody for WB - ABIN948500
Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. in Human pathology 2013
Human Polyclonal SQLE Primary Antibody for IHC, IHC (p) - ABIN4355785
Nguyen, Barozzi, Faronato, Lombardo, Steel, Patel, Darbre, Castellano, Győrffy, Woodley, Meira, Patten, Vircillo, Periyasamy, Ali, Frige, Minucci, Coombes, Magnani: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. in Nature communications 2015
Taken together, our results support a model whereby the amphipathic helix in squalene monooxygenase N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal.
Both HMGCR (show HMGCR Antibodies) and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 (show SREBF2 Antibodies) homodimer.
Higher Gleason grade was associated with lower LDLR (show LDLR Antibodies) expression, lower SOAT1 (show SOAT1 Antibodies) and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR (show LDLR Antibodies) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (show SOAT1 Antibodies) expression (odds ratio, 0.41; 95% CI 0.21-0.83).
Data indicate that microRNA miR (show MLXIP Antibodies)-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).
our results pinpoint SQLE as a bona fide metabolic oncogene (show RAB1A Antibodies) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.
this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.
overexpression of SQLE in HCC (show FAM126A Antibodies) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.
Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (show MARCH6 Antibodies) (membrane-associated ring finger (show PCGF1 Antibodies) [C3HC4] 6).
MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.
A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (show IGFBP5 Antibodies), SQLE, RAP2B (show RAP2B Antibodies), CLDN1 (show CLDN1 Antibodies), and TBL1XR1 (show TBL1XR1 Antibodies).
Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
Requires a redox partner, but cytochrome p450 reductase (show POR Antibodies) is not the only microsomal reductase that will serve this purpose.
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.
, squalene monooxygenase