Squalene Epoxidase Proteins (SQLE)

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.

list all proteins Gene Name GeneID UniProt
Human SQLE SQLE 6713 Q14534
Mouse SQLE SQLE 20775 P52019
Rat SQLE SQLE 29230 P52020
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Top Squalene Epoxidase Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,649.05
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,616.87
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

More Proteins for Squalene Epoxidase (SQLE) Interaction Partners

Human Squalene Epoxidase (SQLE) interaction partners

  1. Taken together, our results support a model whereby the amphipathic helix in squalene monooxygenase N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal.

  2. Both HMGCR (show HMGCR Proteins) and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 (show SREBF2 Proteins) homodimer.

  3. Higher Gleason grade was associated with lower LDLR (show LDLR Proteins) expression, lower SOAT1 (show SOAT1 Proteins) and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR (show LDLR Proteins) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (show SOAT1 Proteins) expression (odds ratio, 0.41; 95% CI 0.21-0.83).

  4. Data indicate that microRNA miR (show MLXIP Proteins)-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).

  5. our results pinpoint SQLE as a bona fide metabolic oncogene (show RAB1A Proteins) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.

  6. this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.

  7. overexpression of SQLE in HCC (show FAM126A Proteins) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.

  8. Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (show MARCH6 Proteins) (membrane-associated ring finger (show PCGF1 Proteins) [C3HC4] 6).

  9. MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.

  10. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (show IGFBP5 Proteins), SQLE, RAP2B (show RAP2B Proteins), CLDN1 (show CLDN1 Proteins), and TBL1XR1 (show TBL1XR1 Proteins).

Mouse (Murine) Squalene Epoxidase (SQLE) interaction partners

  1. Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.

  2. results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.

  3. Requires a redox partner, but cytochrome p450 reductase (show POR Proteins) is not the only microsomal reductase that will serve this purpose.

Squalene Epoxidase (SQLE) Protein Profile

Protein Summary

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.

Gene names and symbols associated with Squalene Epoxidase Proteins (SQLE)

  • squalene epoxidase (SQLE)
  • squalene epoxidase (ANI_1_450034)
  • squalene epoxidase (AOR_1_1218114)
  • squalene epoxidase (CC1G_03987)
  • squalene epoxidase (BDBG_08449)
  • squalene epoxidase (MCYG_02365)
  • squalene epoxidase (TERG_05717)
  • squalene epoxidase (Sqle)
  • AI323792 protein
  • An03g03770 protein
  • AO090701000685 protein

Protein level used designations for Squalene Epoxidase Proteins (SQLE)

squalene epoxidase , squalene monooxygenase , SE

GENE ID SPECIES
100067615 Equus caballus
4980366 Aspergillus niger CBS 513.88
5995549 Aspergillus oryzae RIB40
6007557 Coprinopsis cinerea okayama7130
8508601 Ajellomyces dermatitidis SLH14081
9226506 Arthroderma otae CBS 113480
10376061 Trichophyton rubrum CBS 118892
100125351 Ovis aries
6713 Homo sapiens
608021 Canis lupus familiaris
100113409 Sus scrofa
526535 Bos taurus
20775 Mus musculus
29230 Rattus norvegicus
420335 Gallus gallus
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