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The protein encoded by SKAP2 belongs to the src family kinases. Additionally we are shipping SKAP2 Antibodies (81) and and many more products for this protein.
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Skap2 is essential to activate the beta2 integrins, and loss of Skap2 function is sufficient to cause a leukocyte adhesion deficiency (LAD)-like phenotype in mice.
Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs.
RA70/Scap2 may be necessary for RA-induced neuronal differentiation from the posterior neuroectoderm.
a novel role of SKAP-Hom and its phosphorylation in the regulation of cellular motility.
integrin activation by the ADAP-SKAP55-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.
Sirpalpha is not exclusively immunoinhibitory, and illuminate previously unexplained observations implicating Skap2 and Sirpalpha in mouse models of inflammatory disease.
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
M-CSF receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin
SKAP-HOM is required for proper activation of the immune system, likely by regulating the cross-talk between immunoreceptors and integrins.
A signaling module comprising the cytosolic adapter proteins ADAP and SKAP55 is involved in TCR-mediated inside-out signaling and, the interaction between ADAP and SKAP55 is mandatory for integrin activation.
Results describe a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for T cell receptor-mediated integrin activation.
SKAP-HOM expression in DCs is required for the induction of an optimal immune response; antigen-dependent conjugate formed between wild-type T cells and SKAP-HOM(-/-) DCs is delayed
Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement.
SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for Non-small cell lung cancer treatment.
results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2-cortactin complex
analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
cloning & characterization of an adaptor protein that functions as a downstream target for RAFTK & plays a role in alpha-synuclein phosphorylation
studies provide insights into the molecular mechanism ofrelated adhesion focal tyrosine kinase (RAFTK) autophosphorylation and the specific role of Src in the regulation of RAFTK activation
Overexpression of SKAP2 is associated with the development of pancreatic ductal adenocarcinoma
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.
src kinase-associated phosphoprotein 2-B
, SRC kinase associated phosphoprotein 2
, SKAP55 homolog
, SKAP55 homologue
, Src-associated adaptor protein
, pyk2/RAFTK-associated protein
, src family-associated phosphoprotein 2
, src kinase-associated phosphoprotein 2
, src kinase-associated phosphoprotein 55-related protein
, src-associated adapter protein with PH and SH3 domains
, Fyn-associated phosphoprotein SKAP55 homologue
, Pyk2/RAFTK-associated protein
, retinoic acid-induced protein 70
, src family associated phosphoprotein 2
, src kinase-associated phosphoprotein of 55-related protein
, src-associated adaptor protein
, Src kinase-associated phosphoprotein 2