StAR-Related Lipid Transfer (START) Domain Containing 13 Proteins (STARD13)

STARD13 encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. Additionally we are shipping STARD13 Antibodies (27) and STARD13 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STARD13 90627 Q9Y3M8
STARD13 243362 Q923Q2
Rat STARD13 STARD13 498130  
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Top STARD13 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$932.80
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STARD13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for StAR-Related Lipid Transfer (START) Domain Containing 13 (STARD13) Interaction Partners

Human StAR-Related Lipid Transfer (START) Domain Containing 13 (STARD13) interaction partners

  1. DLC2 is abundantly expressed in hepatocellular carcinoma, in which the DLC2 gene is diploid.

  2. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated.

  3. Low STARD13 expression is associated with metastasis of breast cancer.

  4. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.

  5. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity.

  6. meta-analysis of two Caucasian cohorts did not show an association between five aneurysm associated loci and sporadic brain Arteriovenous malformations.

  7. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association.

  8. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility.

  9. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP.

  10. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process.

  11. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review]

  12. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development.

  13. Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation.

  14. role of miR-125b in pro-metastasis by targeting STARD13

  15. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth.

  16. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues

  17. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma

Mouse (Murine) StAR-Related Lipid Transfer (START) Domain Containing 13 (STARD13) interaction partners

  1. Stard13 regulates insulin secretion in response to glucose via actin cytoskeleton remodeling.

  2. Results indicate that Stard13 acts as a metastasis suppressor rather than a tumor suppressor gene, in Neu oncogene induced mammary tumorigenesis.

  3. role of miR-125b in pro-metastasis by targeting STARD13

  4. DLC2 plays a key role in pain modulation during inflammation by suppressing the activation of RhoA and ERK to prevent an exaggerated pain response

  5. Results suggest that DLC2 exhibits its tumor suppressor functions in vivo as a GAP specific for RhoA, exerting its effects in suppression of cytoskeleton reorganization, cell growth, cell migration, and transformation.

  6. START-GAP2 is localized in focal adhesions through a "FAT (focal adhesion targeting)" region in the N-terminal half.

STARD13 Protein Profile

Protein Summary

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with STARD13

  • StAR related lipid transfer domain containing 13 (STARD13)
  • StAR-related lipid transfer (START) domain containing 13 (Stard13)
  • StAR-related lipid transfer domain containing 13 (Stard13)
  • ARHGAP37 protein
  • DLC2 protein
  • GT650 protein
  • LINC00464 protein
  • RGD1564816 protein

Protein level used designations for STARD13

46H23.2 , DLC-2 , Rho GTPase activating protein on chromosome 13q12 , deleted in liver cancer 2 protein , long intergenic non-protein coding RNA 464 , stAR-related lipid transfer protein 13 , START domain-containing protein 13 , serologically defined colon cancer antigen 13 , serologically defined colon cancer antigen 28 , StAR-related lipid transfer (START) domain containing 13

GENE ID SPECIES
90627 Homo sapiens
243362 Mus musculus
498130 Rattus norvegicus
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