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SDHD encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies (43) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (6) and many more products for this protein.
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Mutations in one of the five genes encoding the succinate dehydrogenase (show SDHA Proteins) or mitochondrial complex II cause the corresponding family syndromes characterized by the occurrence of pheochromocytomas and paragangliomas--REVIEW
A targeted familial genetic test should be proposed from the age of 18 years to every subject having a mother carrying a germline SDHD mutation and a first medical workup, including imaging, should be recommended to SDHD-positive mutation carriers
Loss of SDHD gene is associated with paragangliomas.
promoter mutation seems to be a rare event in CM but SDHD lower expression might associate with worst prognostic features in CM
role for GABPA (show GABPA Proteins)/B1 as the critical ETS (show ETS1 Proteins) transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma.
SDH-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.
For classification, tumors were characterized by SDHA (show SDHA Proteins), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline
Heterozygous germline deletions of up to 104 kb in size were identified in SDHB (show SDHB Proteins), SDHC (show SDHC Proteins), SDHD and flanking genes in 20 paraganglioma-pheochromocytoma patients. The exact breakpoint could be determined in 16 paraganglioma-pheochromocytoma patients of which 15 were novel deletions
our study reveals a novel mechanism of crosstalk amongst SDHD, PTEN and autophagy pathways and their potential roles in thyroid carcinogenesis
According to international guidelines, SDHB (show SDHB Proteins), SDHC (show SDHC Proteins), and SDHD genetic testing were performed in this patient, but not SDHA (show SDHA Proteins), which would have been prescribed only after surgery, in case of SDHA (show SDHA Proteins) negative immunohistochemistry
The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.
the actual dependency of undifferentiated hematopoietic stem cells on mitochondrial function, we have performed an analysis of the hematopoiesis in a mouse mutant, named SDHD-ESR (show ESR1 Proteins), with inducible deletion of the mitochondrial protein (show COX6B2 Proteins)-encoding SdhD gene, is reported.
Loss of SDH (show SDS Proteins) activity leads to changes in the metabolism of non-essential amino acids.
In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Proteins) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p21(WAF1/Cip1 (show CDKN1A Proteins)), a factor implicated in cell cycle, senescence, and cancer.
complete loss of SdhD is not sufficient to induce tumorigenesis in mice
SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.
Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Proteins) may not be an initiator of PGL (show PGLS Proteins)/PC tumorigenesis
Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
, succinate-ubiquinone oxidoreductase cytochrome b small subunit
, succinate-ubiquinone reductase membrane anchor subunit
, Succinate dehydrogenase complex subunit D
, Succinate-ubiquinone oxidoreductase cytochrome b small subunit
, Succinate-ubiquinone reductase membrane anchor subunit
, succinate dehydrogenase complex subunit D