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SDS3 is a subunit of the histone deacetylase (see HDAC1\; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Suppressor of Defective Silencing 3 Homolog (S. Cerevisiae) Antibodies (26) and and many more products for this protein.
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studies reveal that loss of FAM60A or another component of the Sin3 complex, SDS3, leads to a change in cell morphology and an increase in cell migration
Our results have demonstrated that these hyaluronan binding motifs (HABMs) in USP17 and its substrate SDS3 are mainly involved in the inhibition of anchorage-independent tumor growth.
SDS3, being a substrate of USP17, may play an important role in developing a novel therapeutic means to inhibit specific HDAC activities in cancer.
the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors
These data define a role for Suds3 in activation of FGF4/ERK signaling.
the identification of Sds3 (suppressor of defective silencing 3) as an adaptor protein that recruits the Sin3 [SWI (switch)-independent 3]-HDAC (histone deacetylase) repression complex and binds Foxk1.
mSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells.
capacity of mSds3 to cooperate with p53 deficiency in cancer predisposition relates to its specific role in chromosome segregation, rather than its central role in maintaining a functional mSin3A complex
SDS3 is a subunit of the histone deacetylase (see HDAC1\; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003
sin3 histone deacetylase corepressor complex component SDS3
, suppressor of defective silencing 3 homolog (S. cerevisiae)
, 45 kDa Sin3-associated polypeptide
, sin3A-associated protein, 45kDa
, suppressor of defective silencing 3 protein homolog