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acts to lower surface tension in lung alveoli [RGD, Feb 2006]..
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In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A (show SFTPA1 Antibodies) and SPC (show SFTPC Antibodies) but not SPB and SPD (show SFTPD Antibodies) expression.
Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 (show YWHAZ Antibodies) activity and arachidonic acid production.
Surfactant protein B had decreased levels in influenza A virus PR8-infected cells, which was confirmed by immunoblotting and immunofluorescence assays.
macrophages participate in the repression of SFTPB expression by LPS (show TLR4 Antibodies), and that macrophage-released cytokines (including TNF (show TNF Antibodies)) regulate the transcription factor CEBPB (show CEBPB Antibodies)
ErbB4 regulates the expression of surfactant protein B in fetal lung maturation, helping to prepare for the fetal-neonatal transition.
The stimulatory effects of estrogen on Sftpb are under transcriptional control of ErbB4 (show ERBB4 Antibodies).
SP-B contributes to innate host defense of the lung by supplementing the nonoxidant antimicrobial defenses of alveolar macrophages
DNA methylation and chromatin modifications cooperate with Nkx2-1 to regulate Sftpb gene cell specific expression.
formation of the intersubunit disulfide bridge is not critical for SP-B function
The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice.
acts to lower surface tension in lung alveoli
pulmonary surfactant-associated protein B
, pulmonary surfactant-associated proteolipid SPL(Phe)
, surfactant associated protein B
, surfactant pulmonary-associated protein B
, surfactant, pulmonary-associated protein B