anti-Surfactant Associated Protein B (SFTPB) Antibodies

SFTPB encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Additionally we are shipping SFTPB Kits (59) and SFTPB Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SFTPB 6439 P07988
SFTPB 20388 P50405
SFTPB 192155 P22355
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Top anti-SFTPB Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SFTPB Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  721_B cell lysate Host:  Mouse  Target Name:  SFTPB  Sample Tissue:  Mouse Liver  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Surfactant Protein B expression in HepG2 (A), Y79 (B), A549 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Mouse Liver Tissue. Figure. Western Blot; Sample: Recombinant SPB, Mouse. 100 μg Log in to see 15 to 18 Days
$342.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Rat Lung Tissue. 100 μg Log in to see 13 to 16 Days
$362.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$181.73
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis SP-B using LOVO whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis using SFTPB Antibody (Center) Cat.-No AP53885PU-N in HepG2 cell line lysates (35ug/lane). This demonstrates the SFTPB antibody detected the SFTPB protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB SFTPB Antibody (Center)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SFTPB antibody detected the SFTPB protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded lung tissue 100 μg Log in to see 13 to 16 Days
$332.00
Details

Top referenced anti-SFTPB Antibodies

  1. Human Polyclonal SFTPB Primary Antibody for IHC (p), IHC - ABIN269321 : Guo, Kazadaeva, Ortega, Manjunath, Desai: Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. in Developmental biology 2017 (PubMed)

  2. Human Polyclonal SFTPB Primary Antibody for IHC, WB - ABIN4891754 : Mayor, Finch, Zehr, Morselli, Neinast, Frank, Hahner, Wang, Rakheja, Palmer, Rosenfeld, Savani, Clegg: Maternal high-fat diet is associated with impaired fetal lung development. in American journal of physiology. Lung cellular and molecular physiology 2015 (PubMed)

More Antibodies against SFTPB Interaction Partners

Human Surfactant Associated Protein B (SFTPB) interaction partners

  1. Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis.

  2. rs7316 polymorphism associated with respiratory distress syndrome in Iranian premature newborns

  3. TGF beta markedly decreased expression of SP-A, SP-B, SP-C, fatty acid synthase, and the phospholipid transporter ABCA3. However, TGF beta increased protein levels of SP-D with little change in mRNA levels.

  4. Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production.

  5. Data show that the thermal transitions observed in N-terminal propeptide of proSP-B (SP-BN) may correspond to the unfolding of certain protein domains or subdomains and/or to oligomers dissociation whereas the overall protein shows resistance to temperature-induced unfolding up to ~ 86 degrees C.

  6. SP-A (+186A/G) and SP-B (1580C/T) polymorphisms are strongly associated with the risk of respiratory distress syndrome (RDS) in preterm infants. Notably, reduced serum SP-A levels were correlated with a high risk of RDS and may serve as novel biomarkers for RDS detection and monitoring.

  7. Differences were found regarding SPA and pro-SPB expression in the vast majority of subjects: in some lungs, SPA was more expressed whereas in others pro-SPB showed an higher degree of immunoreactivity. The expression of both surfactant proteins was not strictly correlated with gestational age.

  8. There is no significant association between the gene polymorphism of the R236C site in exon 7 of SP-B gene and the incidence ofneonatal respiratory distress syndrome (NRDS) in Han populations in that region.

  9. Rare mutations in surfactant-associated genes contribute to neonatal respiratory distress syndrome. The frequency of mutations in these genes in the Chinese population is unknown. We resequenced all exons of the surfactant protein-B (SFTPB) and we did not find any rare mutations in SFTPB

  10. mice with SP-B-C allele are more susceptible to S. aureus pneumonia than mice with SP-B-T allele, and that CMC2.24 attenuates lung injury thus reducing mortality.

  11. In term newborns with pneumonia, SP-B increases with respect to total phospholipids, and disaturated-phosphatidylcholine and is turned over at a faster rate.

  12. SP-B -18C/A and 1580C/T polymorphisms are associated with bronchopulmonary dysplasia

  13. These results demonstrate for the first time that human SP-B C allele is more susceptible to bacterial pneumonia than SP-B T allele in vivo.

  14. Significant differences in frequency of occurrence of unfavorable genotypes CC rs1965708, AA rs1059046 of SFTPA2 gene and CC rs1130866 of SFTPB gene in influenza patients in comparison with individuals of the control group were not detected.

  15. Investigated the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates.

  16. Given these fact SP-B deficiency may be considered as a further field for research on regenerative therapy i. e. stem cell administration in models of postnatal SP-B deficiency.

  17. Results support a critical role of SP-B for promoting pulmonary surface film formation.

  18. SFTPB variants are associated with chronic obstructive pulmonary disease susceptibility and lung function in the Chinese Han population.

  19. Surfactant protein B gene polymorphism is associated with severe influenza.

  20. data support the hypothesis that proSP-B glycosylation due to Ile131Thr variation may have a causal role in genetic susceptibility to acute respiratory distress

Mouse (Murine) Surfactant Associated Protein B (SFTPB) interaction partners

  1. EMC3 was essential for the processing and routing of surfactant proteins, SP-B and SP-C, and the biogenesis of the phospholipid transport protein ABCA3.

  2. In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A and SPC but not SPB and SPD expression.

  3. Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production.

  4. These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function.

  5. Surfactant protein B had decreased levels in influenza A virus PR8-infected cells, which was confirmed by immunoblotting and immunofluorescence assays.

  6. macrophages participate in the repression of SFTPB expression by LPS, and that macrophage-released cytokines (including TNF) regulate the transcription factor CEBPB

  7. Tuberous sclerosis complex 1 contributes to the regulation of synthesis of surfactant proteins A and B.

  8. ErbB4 regulates the expression of surfactant protein B in fetal lung maturation, helping to prepare for the fetal-neonatal transition.

  9. The stimulatory effects of estrogen on Sftpb are under transcriptional control of ErbB4.

  10. SP-B contributes to innate host defense of the lung by supplementing the nonoxidant antimicrobial defenses of alveolar macrophages

  11. DNA methylation and chromatin modifications cooperate with Nkx2-1 to regulate Sftpb gene cell specific expression.

  12. formation of the intersubunit disulfide bridge is not critical for SP-B function

  13. The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice.

  14. This protein inhibits endotoxin-induced lung inflammation.

  15. Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function.

  16. SP-B expression is regulated by PPARgamma in the lung

  17. napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide

  18. Results indicate that hypoxia-induced mitogenic factor induces surfactant protein B and C production in mouse lungs and cell lines via activation of phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinases.

  19. absence of HO-1 in the lung parenchyma, not in bone marrow-derived inflammatory cells, was responsible for enhanced SP-B downregulation and severe physiologic lung dysfunction

  20. Via promoter mutation analysis, adjacent TTF-1 binding sites within the proximal promoter region of SP-C were found to be essential for TTF-1/TAP26-enhanced SP-C promoter activity.

Pig (Porcine) Surfactant Associated Protein B (SFTPB) interaction partners

  1. Based on these multiple observations, this study proposes a model for SP-B/SP-C interactions, where SP-C might induce conformational changes on SP-B complexes, affecting its aggregation state.

  2. Data show that detergent-solubilized surfactant protein B (SP-B) indicate the presence of 10 nm ring-shaped particles.

  3. Data suggest that transient exposure of surfactant to polymers like hyaluronan (HA) could be a promising strategy for the production of more efficient therapeutic surfactants SP-A, SP-B and SP-C preparations.

  4. Data indicate that in the background of phosphatidylcholine (POPC) membranes pulmonary surfactant protein SP-B exhibits a certain level of selectivity for anionic fluorescent phospholipids over the corresponding zwitterionic analogues.

  5. SP-B and SP-C proteins promote the formation of proteolipid channels in which lipid molecules are functionally involved.

  6. Palmitoylation is key for the functional cooperation of SP-C with SP-B that enables cholesterol-containing surfactant films to reach very low tensions under compression.

  7. Surfactant protein SP-B promoted film formation and reextension to lower surface tensions than SP-C.

  8. The role of the SP-B NH(2) terminus in the formation and stability of cylindrical structures, specifically the distribution of lipid stack height, width, and density with four SP-B truncation peptides, was studied.

  9. SP-B is unlikely to affect uptake of surfactant

  10. The presence of phosphatidylglycerol iz required for SP-B to acquire the appropriate tertiary folding.

  11. SFTPB is located on pig chromosome 3, and is secreted by pulmonary alveolar type II epithelial cells. It is down-regulated during Actinobacillus pleuropneumoniae lung infection.

  12. We show that the presence of SP-B profoundly affects the different collapse steps and facilitates the buildup of multilayer deposits of phospholipid unilamellar vesicles

Cow (Bovine) Surfactant Associated Protein B (SFTPB) interaction partners

  1. Measurements of the depth of SP-B(CTERM) indicated the peptide center positions ~8A more deeply than the phosphate headgroups, a topology that may allow the peptide to promote functional lipid structures without causing micellization upon compression.

  2. results suggest the hydrophobic surfactant protein, SP-B, protects alveolar surfactant phospholiopids from hydrolysis mediated by multiple sPLA(2) in both vesicles (alveolar subphase) and monomolecular films (air-liquid interface)

  3. The hydrophobic surfactant proteins SP-B and SP-C induce formation of bicontinuous inverse cubic phases.

  4. Reactive oxygen species inactivation of lipid extract surfactant B (SP-B) biophysical activity appears to involve modification of a maximum of three amino acids: Trp9, Met29, and Met65.

SFTPB Antigen Profile

Protein Summary

This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with SFTPB

  • surfactant protein B (SFTPB) antibody
  • surfactant associated protein B (Sftpb) antibody
  • surfactant protein B (Sftpb) antibody
  • surfactant, pulmonary-associated protein B L homeolog (sftpb.L) antibody
  • AI562151 antibody
  • PSP-B antibody
  • SF-B antibody
  • SFTB3 antibody
  • Sftp-3 antibody
  • Sftp3 antibody
  • sftpb antibody
  • SMDP1 antibody
  • Sp-b antibody
  • xSP-B antibody

Protein level used designations for SFTPB

18 kDa pulmonary-surfactant protein , 6 kDa protein , pulmonary surfactant-associated protein B , pulmonary surfactant-associated proteolipid SPL(Phe) , surfactant associated protein B , surfactant pulmonary-associated protein B , surfactant, pulmonary-associated protein B , SP-B , surfactant protein B , surfactant, pulmonary-associated protein B L homeolog

GENE ID SPECIES
6439 Homo sapiens
20388 Mus musculus
192155 Rattus norvegicus
397296 Sus scrofa
507398 Bos taurus
100379548 Cavia porcellus
100688334 Canis lupus familiaris
779297 Xenopus laevis
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