Synaptotagmin Like Protein 2 Proteins (SYTL2)

Mouse (Murine) Synaptotagmin Like Protein 2 (SYTL2) interaction partners

1. Our findings indicate that Slp2-a controls renal cell size through regulation of Rap (show LRPAP1 Proteins)-ezrin (show EZR Proteins) signaling independently of Rab27 (show RAB27A Proteins).

2. Slp2-a is required for targeting of the signaling molecule podocalyxin (show PODXL Proteins) to the apical membrane in a Rab27A (show RAB27A Proteins)-dependent manner.

3. Calmodulin suppresses synaptotagmin-2 (show SYT2 Proteins) transcription in cortical neurons

4. Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a

5. Slp2-a is part of the mucin (show SLC13A2 Proteins) secretory machinery in surface mucous cells of mouse stomach

6. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.

7. The structural characterization of the Rab27a (show RAB27A Proteins)-exophilin4/Slp2-a complex will clarify Rab27 (show RAB27A Proteins) recognition by its effectors prior to vesicle tethering and docking.

8. The observed structural complementation between the interacting surfaces of Rab27a (show RAB27A Proteins) and Exophilin4 sheds light on the disparities among the Rab27 (show RAB27A Proteins) effectors and outlines a general mechanism for their recruitment.[exophilin4]

9. Syt2 (show SYT2 Proteins) can serve as an exocytic sensor for diverse Ca(2 (show CA2 Proteins)+) signaling systems, and its levels are limiting for stimulated secretory function in airway goblet cells

10. Stress-induced mitochondrial hyperfusion (SIMH) is independent of MFN2, BAX/BAK, and prohibitins, but requires L-OPA1, MFN1, and the mitochondrial inner membrane protein SLP-2.

Human Synaptotagmin Like Protein 2 (SYTL2) interaction partners

1. Overexpression of SYTL2 promoted metastatic potential.

2. SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma.

3. A high expression level of SLP-2 may be associating with the development of invasion and metastasis in laryngeal squamous cell carcinoma and breast cancer.

4. Calmodulin suppresses synaptotagmin-2 (show SYT2 Proteins) transcription in cortical neurons

5. Exophilin4/Slp2-a is specifically expressed in pancreatic alpha cells.

6. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.

7. Rab27a (show RAB27A Proteins) recruits Slp2a-hem on vesicular structures in peripheral CTLs and following CTL-target (show CTH Proteins) cell conjugate formation, the Slp2a-hem/Rab27a (show RAB27A Proteins) complex colocalizes with perforin (show PRF1 Proteins)-containing granules at the immunologic synapse

8. Rab27A/Slp2a expression in limb girdle muscular dystrophy 2B muscle provides a compensatory vesicular trafficking pathway that is able to repair membrane damage in the absence of dysferlin.

9. Synaptotagmin-like protein 2-a (Slp2-a) contains an N-terminal Slp (show SEPT9 Proteins) homology domain (SHD (show SHD Proteins)) (PMID: 11327731). The SHD (show SHD Proteins) of Slp2-a specifically and directly binds the GTP (show AK3 Proteins)-bound form of Rab27A (show RAB27A Proteins).