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SSX2IP encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein.
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Human Polyclonal SSX2IP Primary Antibody for IHC, IHC (p) - ABIN4356089
Hori, Morand, Ikebe, Frith, Snijders, Toda: The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation. in Biochemical and biophysical research communications 2015
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Human Polyclonal SSX2IP Primary Antibody for ELISA - ABIN250196
de Bruijn, dos Santos, Kater-Baats, Thijssen, van den Berk, Stap, Balemans, Schepens, Merkx, van Kessel: The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. in Genes, chromosomes & cancer 2002
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SSX2IP is required for mitotic centrosome maturation.
This study determined the crystallographic structure of human Afadin (show MLLT4 Antibodies) in complex with LGN (show GPSM2 Antibodies).
Studied afadin (show MLLT4 Antibodies) in complex with beta-catenin (show CTNNB1 Antibodies) in glomeruli and in cultured mesangial cells. Found expression of afadin (show MLLT4 Antibodies) at mesangial intercellular junctions was greatly decreased in mesangial proliferative nephritis in rats & patients w/glomerulonephritis.
Knockdown of Wdr8 (show WDR8 Antibodies) or hMsd1/SSX2IP displayed very similar mitotic defects, in which spindle microtubules became shortened and misoriented.
SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication. On SSX2IP knockdown, the centriolar satellites become stuck at the microtubule minus end near the centrosome.
In airway epithelial cells, measles virus spread requires the nectin-4 (show PVRL4 Antibodies)/afadin (show MLLT4 Antibodies) complex and is based on cytoplasm transfer between columnar cells.
The novel centriolar satellite protein SSX2IP targets Cep290 (show CEP290 Antibodies) to the ciliary transition zone.
results showed that SSX2IP promotes the development and metastasis of hepatocellular carcinoma and contributes to the drug resistance of hepatoma cells
Nuclear protein (show RDBP Antibodies) SS2IP interacts with cancer-related protein SSX2 (show SSX2 Antibodies) and the human homologue of a Ras-like GTPase (show RAB40C Antibodies) interactor, RABIN3 (show RAB3IP Antibodies).
data shows that SSX2IP is affected in two ways that relate to the cell cycling of acute myeloid leukaemia cells
The results indicate that ADIP plays an essential role in PDGF (show PDGFA Antibodies)-induced cell movement by interacting with afadin (show MLLT4 Antibodies) and Vav2 (show VAV2 Antibodies) and regulating the activation of Rac (show AKT1 Antibodies).
This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
, afadin- and alpha-actinin-binding protein
, synovial sarcoma, X breakpoint 2 interacting protein
, afadin- and alpha-actinin-binding protein-like
, SSX2-interacting protein
, afadin DIL domain-interacting protein
, light-inducible and clock-controlled
, afadin- and alpha-actinin-binding protein ADIP