Syntaxin 11 Proteins (STX11)

STX11 encodes a member of the syntaxin family. Additionally we are shipping Syntaxin 11 Antibodies (68) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STX11 8676 O75558
STX11 74732 Q9D3G5
Rat STX11 STX11 292483  
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Top Syntaxin 11 Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human GST tag,His tag Validation with Western Blot 50 μg 6 to 10 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days

STX11 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Syntaxin 11 (STX11) Interaction Partners

Human Syntaxin 11 (STX11) interaction partners

  1. Data suggest that acylation of SNAP23 (synaptosome associated protein 23) and STX11 (syntaxin-11) regulates exocytosis in platelets; maintaining acylation states of SNAP23 and STX11 is important for platelet function.

  2. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion.

  3. The results suggest that STX11 plays an important role in the pathogenesis of Peripheral T-cell lymphomas and they may contribute to the future development of new drugs for the treatment of Peripheral T-cell lymphomas.

  4. a pivotal role for S-acylation in the function of syntaxin 11 in NK cells

  5. Stx11 functions as a t-SNARE for the final fusion of LG at the IS.

  6. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.

  7. These data indicate that human neutrophils express syntaxin 11 and call attention to the possible involvement of neutrophils in familial hemophagocytic lymphohistiocytosis pathology

  8. Platelets deficient in syntaxin-11 from a Familial Hemophagocytic Lymphohistiocytosis type 4 had secretion defect.

  9. Data suggest that syntaxin 11 promotes the fusion of Rab27a-expressing vesicles with cytotoxic granules and reveal additional complexity in spatial/temporal segregation of subcellular structures involved in granule-mediated cytotoxicity.

  10. No detrimental mutations were identified in STX11 in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.

  11. STX11 should be sequenced in HLH patients even when impaired NK cell degranulation is not found

  12. a novel homozygous deletion (c. 581_584delTGCC; p.Leu194ProfsX2) in the gene-encoding syntaxin 11 (STX11), causing a premature termination codon in hemophagocytic lymphohistiocytosis

  13. The mutations in STX11 are responsible for HLH in approximately 1% of North American patients and can cause variable defects in syntaxin 11 expression and function with resultant impact on clinical phenotype.

  14. A large group of 63 unrelated patients with Familial hemophagocytic lymphohistiocytosis (FHL) was analysed for mutations in STX11, PRF1, and UNC13D.

  15. Defective cytotoxic lymphocyte degranulation is associated with syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 patients

  16. Syntaxin 11 plays a role in natural killer (NK) cell granule exocytosis and in the generation of cell-mediated killing.

  17. DNA methylation of Stx11 contribute to disease susceptibility at the 6q24 locus in humans.

  18. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

Mouse (Murine) Syntaxin 11 (STX11) interaction partners

  1. Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.

  2. required for NK and CD8+ T cell cytotoxicity and neutrophil degranulation

  3. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.

  4. Blockade of inhibitory receptors on T cells in Stx11-deficient mice converted nonfatal disease course into fatal HLH, identifying T-cell exhaustion as an important factor for determination of disease severity in hemophagocytic lymphohistiocytosis.

  5. Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages.

  6. Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart.

Syntaxin 11 (STX11) Protein Profile

Protein Summary

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.

Gene names and symbols associated with Syntaxin 11 Proteins (STX11)

  • syntaxin 11 (STX11)
  • syntaxin 11 S homeolog (stx11.S)
  • syntaxin 11 (stx11)
  • syntaxin 11 (Stx11)
  • 5830405C08Rik protein
  • FHL4 protein
  • HLH4 protein
  • HPLH4 protein
  • MGC79075 protein
  • MGC89708 protein

Protein level used designations for Syntaxin 11 Proteins (STX11)

syntaxin 11 , syntaxin-11

428597 Gallus gallus
446481 Xenopus laevis
484019 Canis lupus familiaris
493509 Xenopus (Silurana) tropicalis
539960 Bos taurus
699733 Macaca mulatta
748048 Pan troglodytes
8676 Homo sapiens
74732 Mus musculus
292483 Rattus norvegicus
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