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The product of STX2 belongs to the syntaxin/epimorphin family of proteins.
Showing 10 out of 81 products:
Hamster Polyclonal STX2 Primary Antibody for ICC, IP - ABIN1742219
Arasaki, Roy: Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. in Traffic (Copenhagen, Denmark) 2010
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TGF-beta (show TGFB1 Antibodies), bFGF (show FGF2 Antibodies) and epimorphin in the extracellular microenvironment cooperatively affect HSF (show HSF1 Antibodies) behaviors under the control of a highly sulfated (show SULF1 Antibodies) chondroitin sulfate
The effects of HIV/HCV co-infection on hepatic fibrosis might be mediated in part by epimorphin (EPM). Strategies to limit the expression of EPM might represent a novel therapeutic approach to prevent the progression of hepatic fibrosis during HIV/HCV co-infection.
Identify 3 loci associated with circulating tPA (show PLAT Antibodies) levels, the PLAT (show PLAT Antibodies) region, STXBP5 (show STXBP5 Antibodies), and STX2. Functional studies implicate a novel role for STXBP5 (show STXBP5 Antibodies) and STX2 in regulating tPA (show PLAT Antibodies) release.
Epimorphin can revert ovarian cancer cells away from their mesenchymal phenotype and toward an epithelial phenotype.
epimorphin modulates the signaling pathways mediated by EGFR (show EGFR Antibodies) for epidermal tissue organization
Genetic variation in STX2 is associated with von Willebrand factor:Ag levels in patients diagnosed with type 1 von Willebrand Disease.
EPM, secreted by activated stellate cells within stroma, promotes invasion and metastasis of hepatocellular cancer cells by activating MMP-9 (show MMP9 Antibodies) expression through the FAK (show PTK2 Antibodies)-ERK (show EPHB2 Antibodies) pathway.
Genetic variability in STXBP5 (show STXBP5 Antibodies) and STX2 affects both VWF (show VWF Antibodies) concentration and activity in young individuals with premature arterial thrombosis.
Munc18b (show STXBP2 Antibodies) binds to syntaxins 1A, 2, and 3 and regulates vesicle transport to the apical plasma membrane
These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2 (show MMP2 Antibodies), which is an important proteolytic factor in lung remodeling.
Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin (show INS Antibodies) secretion. The increase in insulin (show INS Antibodies) exocytosis was attributed mainly to an enhanced recruitment of the larger pool of newcomer secretory granules (SGs (show SKI Antibodies)) that undergoes no residence time on plasma membrane before fusion and, to a lesser extent, also the predocked SGs (show SKI Antibodies).
The selectivity in syntaxin binding and apical protein (show SHROOM1 Antibodies) redistribution further suggests that rab17 (show RAB17 Antibodies) and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface.
It was concluded that Epim deletion inhibits polyposis in Apcmin/+ mice, associated with increased mucosal TGF-beta (show TGFB1 Antibodies) signaling and decreased myofibroblast HGF (show HGF Antibodies) expression and secretion.
Overexpression of Epim expression is associated with mammary carcinoma.
These results suggest that STX2 plays roles in transport and/or subcellular distribution of sulfoglycolipids.
Epimorphin regulates bile duct formation via effects on mitosis orientation
Epimorphin has a pivotal role in the repair of renal fibrosis by modulating both extracellular matrix (ECM (show MMRN1 Antibodies)) degradation and its production.
syntaxin 2 enters the membrane of a fused zymogen granule after the opening of the fusion pore
Epimorphin is involved in tissue repair following a single injection of carbon tetrachloride, in which distribution and the quantity of epimorphin expression are important, particularly in maintaining hepatocyte function.
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.
, syntaxin 1B2
, syntaxin 2