T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) ELISA Kits

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Additionally we are shipping TIMD4 Antibodies (118) and TIMD4 Proteins (18) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat TIMD4 TIMD4 497891  
Anti-Mouse TIMD4 TIMD4 276891 Q6U7R4
TIMD4 91937 Q96H15
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Top TIMD4 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details

Top referenced TIMD4 ELISA Kits

  1. Human TIMD4 ELISA Kit for Sandwich ELISA - ABIN852560 : Chen, He, Lu, Zhou, Fang, Liu, Xu: Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis. in Inflammation 2014 (PubMed)

More ELISA Kits for TIMD4 Interaction Partners

Mouse (Murine) T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) interaction partners

  1. the interaction of TIM4TIM1 was found to promote Th2cell proliferation through enhancing SIRT1 expression in mice with nasal allergic rhinitis.

  2. These results indicate that TAM and Tim4 collaborate for efficient efferocytosis in certain macrophage populations.

  3. TIM-4 is expressed on iNKT cells but dispensable for their development and function.

  4. TIM-4 was differentially expressed in the distinct subsets of DCs in skin and skin-draining LNs, and specifically regulated epidermal LC and LN CD207-CD4+ DC homeostasis

  5. identified TIM-4 as a novel marker for B effector 1 (Be1) cells that depend on IFN-gamma for their proinflammatory activity; TIM-4(+) B cells are enriched for IFN-gamma-producing proinflammatory Be1 cells that enhance immune responsiveness and can be specifically targeted with anti-TIM-4.

  6. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).

  7. attenuated LPS-induced endotoxic shock by inhibiting cytokine production by macrophages

  8. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry

  9. STAT6 mediates the CT-induced TIM4 expression in DCs. In conclusion, p300 and STAT6 mediate the microbial product CT-induced TIM4 expression in DCs.

  10. Blockade of Tim-4 aggravates atherosclerosis in LDL receptor knockout mice likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells.

  11. results indicate that Tim-4 is involved in negative regulation of NO production in macrophages, suggesting the critical role of Tim-4 in immune related diseases

  12. TIM-4 on dendritic cells plays a critical role in hepatic ischemia-reperfusion (IR) injury and may be an efficient target for the prevention of liver or other organ IR injuries.

  13. M2-like TIM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts, but their influence is diminished by TIM-4-dependent programmed cell death

  14. intrinsic macrophage-specific TIM-4 signaling has indispensable role in innate immunity-driven liver ischemia-reperfusion injury

  15. TIM4 engages integrins as coreceptors to evoke the signal transduction needed to internalize PtdSer-bearing targets such as apoptotic cells.

  16. Tim-4 expression was higher in Behcet's disease (BD) mice than that in BDN mice.

  17. In addition to the known phosphatidylserine(PS) binding pocket, Tim4 has four weaker sites of interaction, making it sensitive to PS surface concentration in a manner capable of differential recognition on the basis of PS exposure level.

  18. the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK-mediated cell engulfment

  19. Data suggest that trans-membrane (or T cell) immunoglobulin and mucin (TIM) molecules are expressed in embryonic hematopoietic tissues in chicken and mouse and that in fetal liver, TIM-4 is expressed by myeloid progenitor cells.

  20. TIM-4 directly interacted with AMPKalpha1 and activated autophagy-mediated degradation of ingested tumors, leading to reduced antigen presentation and impaired CTL responses

Human T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) interaction partners

  1. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic stroke

  2. High expression of TIMD4 in clear cell renal cancer cells was closely related to short progression free survival time, and was associated with resistance to sorafenib.

  3. VitD deficiency may contribute to the pathogenesis of allergic rhinitis (AR) by increasing the TIM4 expression. The results suggest that to regulate the serum calcitriol levels and the expression of VDR in DCs may be necessary to be taken into account in the treatment of AR.

  4. This study aimed to investigate the association of two TIM-4 SNPs) with systemic lupus erythematosus (SLE)susceptibility in a Chinese Han population.The results imply that GG genotype of the TIM-4 gene at -1419 site might be associated with the disease activity of SLE.

  5. Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells

  6. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry

  7. Tim-4 expression is closely associated with glioma and may have a regulatory role

  8. Data indicate that T cell immunoglobulin and mucin domain containing 4 (TIM-4) contributes, at least in part, to the pathogenesis of type 2 diabetes mellitus (T2D), possibly by regulating interleukin-1beta (IL-1beta).

  9. TIM4 binds TIM3 on the surface of polarized Th1 cells to induce Th1 cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.

  10. TIM-4 rs7700944 and not TIM-1 rs41297579 G>A (-1454) is associated with rheumatoid arthritis(RA) in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian.

  11. Data showed up-regulation of TIM-4 in lung cancer tissues and a correlation with poor prognosis. Also, TIM-4 was found to promote growth of lung cancer cells by its interaction with integrin alphavbeta3 through its RGD motif.

  12. Tim-4 expression on monocytes and Tim-4 level in plasma were more highly increased in ankylosing spondylitis patients than in controls.

  13. Our study uncovers a novel ability of TIM-family proteins to block the release of HIV-1 and other viruses by interaction with virion- and cell-associated phosphatidylserine.

  14. Our results do not support an association between the rs7700944 polymorphism of the TIM-4 gene and rheumatoid arthritis

  15. Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 protein), TIMD4 (T cell immunoglobulin mucin-4), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW]

  16. TIM4 expression is promoted by Cockroach allergen Bla g 7 in dendritic cells leading to Th2 polarization

  17. TIM-1 and TIM-4 are novel targets for ADAM10- and ADAM17-mediated ectodomain shedding.

  18. FG-CC' siRNA blocking interaction of Tim-1 and Tim-4 can enhance dendritic cell vaccine activity against gastric cancer.

  19. There were four SNPs in the promoter region of TIM4 in asthma patients of Chinese Han population, which were in linkage disequilibrium.

  20. TIM-4 variant or a highly correlated nearby gene of the TIM-4 gene may play a critical role in the pathogenesis of rheumatoid arthritis in many ethnicities.

TIMD4 Antigen Profile

Antigen Summary

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

Gene names and symbols associated with TIMD4

  • T-cell immunoglobulin and mucin domain containing 4 (Timd4) antibody
  • T-cell immunoglobulin and mucin domain containing 4 (TIMD4) antibody
  • T-cell immunoglobulin and mucin domain containing 4 L homeolog (timd4.L) antibody
  • T cell immunoglobulin and mucin domain containing 4 (Timd4) antibody
  • B430010N18Rik antibody
  • MGC99322 antibody
  • RGD1564516 antibody
  • SMUCKLER antibody
  • TIM-4 antibody
  • TIM4 antibody
  • TIMD4 antibody

Protein level used designations for TIMD4

T-cell immunoglobulin and mucin domain containing 4 , T-cell immunoglobulin and mucin domain-containing protein 4 , T-cell membrane protein 4 , TIMD-4 , smuckler , spleen, mucin-containing, knockout of lymphotoxin protein , TIM-4

GENE ID SPECIES
497891 Rattus norvegicus
416250 Gallus gallus
447692 Xenopus laevis
462217 Pan troglodytes
489160 Canis lupus familiaris
507549 Bos taurus
100597340 Nomascus leucogenys
276891 Mus musculus
91937 Homo sapiens
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