T-Cell Leukemia Homeobox 3 Proteins (TLX3)

Human T-Cell Leukemia Homeobox 3 (TLX3) interaction partners

1. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL (show PMEL Proteins)/TAL (show TALDO1 Proteins) but a higher incidence of NKX2-5 (show NKX2-5 Proteins) expression than recorded in Western countries

2. Immunophenotyping with CD135 (show FLT3 Proteins) and CD117 predicts the FLT3 (show FLT3 Proteins), IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.

3. Studies suggest that homeobox protein TLX3 expression is not an indicator for the prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL).

4. these results place TLX1 (show TLX1 Proteins) and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 (show RUNX1 Proteins) as a tumor-suppressor gene in T-ALL

5. The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 (show TLX1 Proteins) or TLX3 is due to binding of TLX1 (show TLX1 Proteins)/TLX3 to ETS1 (show ETS1 Proteins).

6. We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test.

7. Results identify Tlx3 as a novel target for canonical Wnt (show WNT2 Proteins) signaling that confers somatic stem cells with a sensory neuron phenotype upon neural induction.

8. High TLX3/BCL11B fusion protein expression is associated with T/myeloid acute bilineal leukemia.

9. HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.

10. Authors conclude that RNX, and presumably its expression, are not altered in the index cases of congenital central hypoventilation syndrome.

Mouse (Murine) T-Cell Leukemia Homeobox 3 (TLX3) interaction partners

1. These results demonstrate a novel role for Tlx3 and indicate that Pax6 (show PAX6 Proteins)-Tlx3 expression and interaction is part of a region specific regulatory network in cerebellum and its deregulation during development could possibly lead to Autistic spectral disorders (ASD (show GUSB Proteins)).

2. Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP (show CREBBP Proteins).

3. Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 (show DRGX Proteins) activity, either by controlling its transcriptional levels or by increasing Prrxl1 (show DRGX Proteins) phosphorylation state.

4. The tlx2 (show TLX2 Proteins) knockout mice failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm and development of a subset of excitatory neurons located in laminae I and II was impaired.

5. Tlx3 is required for the acquisition of cholinergic phenotype at the late embryonic stage as well as the expression and maintenance of cholinergic peptides

6. This study demonistrated that Tlx3 and Runx1 (show RUNX1 Proteins) act in combination to coordinate the development of nociceptors, thermoceptors, and pruriceptors.

7. Tlx1 (show TLX1 Proteins)/3 and Ptf1a (show PTF1A Proteins), the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord

8. This study found that Tlx3 was required for specification of, and expressed in, glutamatergic neurons. and ectopic expression of Tlx3 was sufficient to suppress GABAergic differentiation and induce formation of glutamatergic neurons.

9. Lbx1 (show Lbx1 Proteins) and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.

10. The sequential and coordinated expression of the proneural and neuronal subtype-specific genes identifies Tlx3 as a selector gene in ES cells undergoing neural differentiation