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TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. Additionally we are shipping TBC1D1 Kits (9) and TBC1D1 Proteins (5) and many more products for this protein.
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Human Polyclonal TBC1D1 Primary Antibody for WB - ABIN541309
Roach, Chavez, Mîinea, Lienhard: Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. in The Biochemical journal 2007
Show all 3 Pubmed References
Human Polyclonal TBC1D1 Primary Antibody for ELISA, WB - ABIN1003252
White, Pasztor, Richardson, Zon: The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. in Cytogenetics and cell genetics 2000
Show all 2 Pubmed References
the TBC1D1 gene has an effect on meat, carcass and production traits in Italian heavy pigs.
TBC1D1-Ser(231) phosphorylation and/or 14-3-3 binding partially mediates AMPK-governed glucose homeostasis and muscle glucose uptake in a context-dependent manner.
data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT
AS160 and TBC1D1 phosphorylations were evident 30 min after exercise.
Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells.
Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain.
R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction.
Data suggest that insulin increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration.
TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise.
[review] The question of a mechanism for increased phosphorylation of Ser237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise.
A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle.
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
coding variant R125W affects obesity susceptibility, delimits the location of an obesity gene at 4q34-35 and identifies a gene/gene interaction that influences the risk for obesity predisposition
form of Tbc1d1 also inhibited GLUT4 translocation and that this effect also required a functional GAP domain
These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6\; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
, TBC1 domain family member 1-like
, TBC1 domain family member 1
, TBC1 domain family, member 1
, tre-2/USP6, BUB2, cdc16) domain family, member 1