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TBC1D15 encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. Additionally we are shipping TBC1D15 Proteins (2) and many more products for this protein.
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Demonstrate that TBC1D15 and TBC1D17 (show TBC1D17 Antibodies) mediate proper autophagic encapsulation of mitochondria by regulating Rab7 (show RAB7B Antibodies) activity at the interface between mitochondria and isolation membranes.
TBC1D15 is required for the accumulation of RhoA (show RHOA Antibodies).
Fis1 (show FIS1 Antibodies) acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology.
although only TBC1D15/Rab7-GAP altered Rab7 (show RAB7B Antibodies)-GTP (show AK3 Antibodies) levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
This paper primarily describes (show RAB7B Antibodies)mouse TBC1D15 but also reports the primary structure of human TBC1D15.
nigericin-induced mitochondria fission was rescued by knockdown of either dynamin-related protein 1 (show DNM1L Antibodies) or TBC1 domain family member 15 (TBC1D15), which are two distinct mitochondria fission regulators, only TBC1D15 restored the activity of the STING pathway, which indicates that inflammasome-activating signals curtail STING pathway activation via TBC1D15.
identify TBC1D15 as a Numb (show NUMB Antibodies)-associated protein and demonstrate that its amino-terminal domain disengages p53 (show TP53 Antibodies) from Numb (show NUMB Antibodies), triggering p53 (show TP53 Antibodies) proteolysis and promoting self-renewal and pluripotency
although only TBC1D15/Rab7-GAP altered Rab7 (show RAB7A Antibodies)-GTP (show AK3 Antibodies) levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
TBC1D15 may be involved in Rab7 (show RAB7A Antibodies)-mediated late endosomal trafficking
This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants.
GAP for RAB7
, GTPase-activating protein RAB7
, TBC1 domain family member 15
, Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15
, Tre2/Bub2/Cdc16 domain family member 15
, lymphocyte antigen 6, locus D ligand