TLP Prevents p53 Degradation through Disrupting the p53-MDM2 Interaction.
The interaction of TBP-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP-like protein
miR18a exhibits a protective role in colorectal cancer (CRC) via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene.
results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53
Western blotting and immunohistochemistry both indicated a higher TBPL1 protein expression level in colorectal cancer tissue. siRNA for TBPL1 transfection obviously slowed down the cell proliferation in both SW-620 and HT-29 cells.
TLP mediates p53-governed transcriptional activation of the p21 upstream promoter.
Data show that during interphase, endogenous or exogenously expressed TRF2 is located almost exclusively in the nucleolus
TLF is a functional regulator of transcription with targets distinct from those of TBP.
the knockdown of the endogenous TLP reduced etoposide-induced apoptosis through repression of TAp63 expression. Taken together, our present study identifies a TLP-TAp63 pathway that is further implicated in stress-induced apoptosis.
Trf2 forms a stable complex with TFIIA or the testis expressed paralogue ALF chaperoned in the cytoplasm by heat shock proteins. It is recruited to active haploid cell promoters together with Tbp, Taf7l and RNA polymerase II. A set of genes activated in haploid spermatids during the first wave of spermatogenesis is down-regulated by Trf2 inactivation.
Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression.
Transplantation of TRF2 overexpressing bone marrow cells into the hematopoietic system of mice resulted in the the development of T-cell lymphomas, but overexpression of the TRF2 transgene was not detectable anymore in the tumors.
transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
TBP-related factor 2 (TRF2) has a role in mouse spermatogenesis
reconfirmed cytoplasmic localization of TRF2; genotoxins caused it to migrate to the nucleus; TRF2 may be involved in genotoxin-induced transcriptional regulation
these results demonstrate that TRF2 increased expression is a potent oncogenic event that along with telomerase deficiency accelerates carcinogenesis, coincidental with a derepression of telomere recombination
Data report on the nucleosomal organization of telomeres that have become deprotected through the deletion of the shelterin components TRF2 or POT1a/b, and show no evidence of changes or nucleosome eviction near the telomere terminus.
Role of TRF2 mRNA in male germ cells: In transgenic animals deficient in TRF2, spermatid development fails during early spermiogenesis with increased apoptosis and failure to develop testicular spermatozoa. Infertility phenotype in homozygote males.
Mice lacking the TBP-related factor 2 (TRF2) gene, which is highly expressed in the testis, have a severe defect in spermiogenesis. TRF2 expression is shown to be cell type- and stage-specific and play an essential regulatory role in development.
Arabidopsis Pol II is indispensable for endogenous siRNA-mediated transcriptional gene silencing (TGS) at intergenic low-copy-number loci, despite the presence of two other polymerases-Pol IV and Pol V-that specialize in TGS through siRNAs
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.
21-kDA TBP-like protein , TATA box-binding protein-like protein 1 , TATA box-binding protein-related factor 2 , TBP-related factor 2 , TBP-related protein , second TBP of unique DNA protein , MIID(1)-5.1 (Probe) , MIID-X630 , TATA sequence-binding protein 1 , TATA-binding factor 1 , TATA-binding protein , TATA-box binding protein , TATA-box factor 1 , TATA-box-binding protein 1 , TATA-box-binding protein 1(TATA-binding factor 1)(TATA sequence-binding protein 1) , TBI , TBP-1 , TFIID , Tbp1_PCR , hypothetical protein , miid1 , pTBI , tbp*-L13301 , transcription initiation factor TFIID TBP-1 subunit , TBP-like factor , TBP-like protein 1 , xlTLF , TATA box binding protein-like 1 , TATA box-binding protein related factor 2 , TBP-like 1 , tata box-binding protein-like protein 1 , 21 kDa TBP-like protein , TATA box binding protein-like protein
GENE ID | SPECIES |
---|---|
9519 | Homo sapiens |
542240 | Zea mays |
395517 | Gallus gallus |
399086 | Xenopus laevis |
463010 | Pan troglodytes |
613818 | Bos taurus |
100101453 | Takifugu rubripes |
100173239 | Pongo abelii |
100232377 | Taeniopygia guttata |
100346981 | Oryctolagus cuniculus |
100528854 | Ictalurus punctatus |
237336 | Mus musculus |
689030 | Rattus norvegicus |
403035 | Danio rerio |
476209 | Canis lupus familiaris |
820546 | Arabidopsis thaliana |