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The protein encoded by THAP11 contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases..
Showing 10 out of 88 products:
Human Monoclonal THAP11 Primary Antibody for BI, IF - ABIN2689892
Dejosez, Levine, Frampton, Whyte, Stratton, Barton, Gunaratne, Young, Zwaka: Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. in Genes & development 2010
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Human Monoclonal THAP11 Primary Antibody for ICC, FACS - ABIN969436
Li, McInnis, Margolis, Antonarakis, Ross: Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. in Genomics 1993
Show all 3 Pubmed References
Human Polyclonal THAP11 Primary Antibody for IF, WB - ABIN528142
Nakamura, Yokota, Tan, Nagata, Takemura, Hirano, Shigeno, Shibata, Fujisawa, Ohnishi: Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. in International journal of cancer. Journal international du cancer 2011
Cow (Bovine) Polyclonal THAP11 Primary Antibody for ELISA - ABIN4247424
Zhu, Li, Li, Zhan, Li, Xu, Xu, Sun, Yang: Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc. in Cell death and differentiation 2009
We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 (show HCFC1 Antibodies) and THAP11 are essential for normal brain development and neural precursor differentiation.
the crystal structure of the C-ter (show TECR Antibodies) region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features.
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (show CISH Antibodies)-element, which engages a THAP11/HCF-1 (show HCFC1 Antibodies) complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros (show IKZF1 Antibodies) and NFKB1 (show NFKB1 Antibodies)
THAP11, ZNF143 (show ZNF143 Antibodies), and HCF-1 (show HCFC1 Antibodies) form a mutually dependent complex on chromatin, which is independent of E2F (show E2F1 Antibodies) occupancy.
that THAP11 reversibly regulated erythroid and megakaryocytic differentiation.
HCFC1 (show HCFC1 Antibodies) is a common component of active human CpG-island promoters and coincides with ZNF143 (show ZNF143 Antibodies), THAP11, YY1 (show YY1 Antibodies), and GABP transcription factor occupancy.
In HCC (show FAM126A Antibodies) patients, the expression of THAP11 mRNA significantly correlated with PCBP1 (show PCBP1 Antibodies) mRNA expression. Our results suggest a novel role of THAP11 in CD44 (show CD44 Antibodies) alternative splicing and hepatoma invasion
identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer
the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell.
Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc (show MYC Antibodies).
The activity of Ronin coincided with the recruitment of its cofactor, Hcf-1 (show HCFC1 Antibodies), and the elevation of H3K4me3 levels at specific target genes, suggesting the involvement of an epigenetic mechanism.
Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 (show GTF2H4 Antibodies) and Rad18 (show RAD18 Antibodies), providing a potential mechanism for this phenotype.
Ronin is a positive regulator of mitochondrial gene expression that coordinates mitochondrial activity and cell cycle progression in the developing retina.
Ronin/Hcf-1 (show HCFC1 Antibodies) controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.
Findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency; its association with HCF-1 (show HCFC1 Antibodies) suggests an epigenetic mechanism of gene repression in pluripotent cells.
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
THAP domain-containing protein 11
, THAP domain containing 11