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The protein encoded by THAP11 contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.. Additionally we are shipping and and many more products for this protein.
Showing 10 out of 90 products:
Human Monoclonal THAP11 Primary Antibody for BI, IF - ABIN2689892
Dejosez, Levine, Frampton, Whyte, Stratton, Barton, Gunaratne, Young, Zwaka: Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. in Genes & development 2010
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Human Monoclonal THAP11 Primary Antibody for ICC, FACS - ABIN969436
Li, McInnis, Margolis, Antonarakis, Ross: Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. in Genomics 1993
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Human Polyclonal THAP11 Primary Antibody for IF, WB - ABIN528142
Nakamura, Yokota, Tan, Nagata, Takemura, Hirano, Shigeno, Shibata, Fujisawa, Ohnishi: Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. in International journal of cancer. Journal international du cancer 2011
Cow (Bovine) Polyclonal THAP11 Primary Antibody for ELISA - ABIN4247424
Zhu, Li, Li, Zhan, Li, Xu, Xu, Sun, Yang: Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc. in Cell death and differentiation 2009
A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance.
We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 and THAP11 are essential for normal brain development and neural precursor differentiation.
the crystal structure of the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features.
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1
THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy.
that THAP11 reversibly regulated erythroid and megakaryocytic differentiation.
HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy.
In HCC patients, the expression of THAP11 mRNA significantly correlated with PCBP1 mRNA expression. Our results suggest a novel role of THAP11 in CD44 alternative splicing and hepatoma invasion
identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer
the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell.
Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc.
The activity of Ronin coincided with the recruitment of its cofactor, Hcf-1, and the elevation of H3K4me3 levels at specific target genes, suggesting the involvement of an epigenetic mechanism.
Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 and Rad18, providing a potential mechanism for this phenotype.
Ronin is a positive regulator of mitochondrial gene expression that coordinates mitochondrial activity and cell cycle progression in the developing retina.
Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.
Findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency; its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells.
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
THAP domain-containing protein 11
, THAP domain containing 11