THO Complex 1 Proteins (THOC1)

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010].. Additionally we are shipping THOC1 Antibodies (90) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
THOC1 9984 Q96FV9
THOC1 225160 Q8R3N6
THOC1 291797  
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Top THOC1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,929.67
Details

THOC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for THO Complex 1 (THOC1) Interaction Partners

Human THO Complex 1 (THOC1) interaction partners

  1. THO (show THOC2 Proteins) interacts with the Sin3A (show SIN3A Proteins) histone deacetylase (show HDAC1 Proteins) complex to suppress co-transcriptional R-loops, DNA damage, and replication impairment. Functional analyses show that histone hypo-acetylation prevents accumulation of harmful R-loops and RNA-mediated genomic instability.

  2. Colorectal cancer patients with high levels of Thoc1 expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 expression survived longer.

  3. In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment.

  4. Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.

  5. This suggests NEDD4-1 (show NEDD4 Proteins) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (show THOC2 Proteins) activity.

  6. overexpression of hTREX84 is associated with cancer cell transformation, proliferation and may be regulated by RelA/p65 (show NFkBP65 Proteins)

  7. We show that human THO (show THOC2 Proteins) depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and gammaH2AX (show H2AFX Proteins) and 53BP1 (show TP53BP1 Proteins) foci accumulation

  8. A differential connection between tumorogenesis and the expression levels of human THO (show THOC2 Proteins) and ALY (show THOC4 Proteins).

  9. hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors

  10. Thoc1 may be important for neoplastic transformation

Mouse (Murine) THO Complex 1 (THOC1) interaction partners

  1. Results found that Thoc1 deficiency delays embryo death, and suggest that Thoc1 is required to support increased expression of E2f (show E2F1 Proteins) and apoptotic regulatory genes that trigger apoptosis upon Rb1 (show RB1 Proteins) loss.

  2. granulocyte macrophage progenitors have a cell autonomous requirement for Thoc1 to maintain cell growth and viability

  3. Thoc1 gene deletion prevents prostate cancer progression in mice, but has little effect on normal tissue. Prostate cancer cells deprived of Thoc1 show gene expression defects that compromise cell growth.

  4. Thoc1 loss compromises the proliferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of differentiated cells in this rapidly renewing tissue.

  5. This suggests NEDD4-1 (show NEDD4 Proteins) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (show THOC2 Proteins) activity.

  6. results demonstrate that NO-mediated thoc1 downregulation, via Nrf2, is a key step in the cancer cell apoptosis induced by CCL-34-treated macrophages

  7. THOC5/Fms interacting protein (show THOC5 Proteins) is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein (show THOC5 Proteins) causes the down-regulation of THOC1, which may contribute to altered THO (show THOC2 Proteins) complex function and cell death

  8. The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described.

  9. These findings support the notion that Thoc1-mediated RNP (show RNPC3 Proteins) assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo.

THOC1 Protein Profile

Protein Summary

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).

Gene names and symbols associated with THO Complex 1 Proteins (THOC1)

  • THO complex 1 (thoc1)
  • THO complex 1 protein L homeolog (thoc1.L)
  • THO complex 1 (THOC1)
  • THO complex subunit 1 (LOC100123388)
  • THO complex 1 protein (thoc1)
  • THO complex 1 (Thoc1)
  • 3110002N20Rik protein
  • AW107452 protein
  • HPR1 protein
  • LRRGT00070 protein
  • MGC114861 protein
  • NMP-84 protein
  • P84 protein
  • P84N5 protein
  • Tho1 protein
  • THOC1 protein

Protein level used designations for THO Complex 1 Proteins (THOC1)

THO complex subunit 1 , THO complex 1 , nuclear matrix protein p84 , THO complex subunit 1-like , THO complex 1 protein , hTREX84 , tho1

GENE ID SPECIES
373077 Danio rerio
398505 Xenopus laevis
421062 Gallus gallus
455324 Pan troglodytes
697954 Macaca mulatta
100051155 Equus caballus
100123388 Nasonia vitripennis
100393939 Callithrix jacchus
100473279 Ailuropoda melanoleuca
100580031 Nomascus leucogenys
100625217 Sus scrofa
733546 Xenopus (Silurana) tropicalis
9984 Homo sapiens
225160 Mus musculus
291797 Rattus norvegicus
490529 Canis lupus familiaris
100138748 Bos taurus
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