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HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010].. Additionally we are shipping THOC1 Antibodies (89) and and many more products for this protein.
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THO (show THOC2 Proteins) interacts with the Sin3A (show SIN3A Proteins) histone deacetylase (show HDAC1 Proteins) complex to suppress co-transcriptional R-loops, DNA damage, and replication impairment. Functional analyses show that histone hypo-acetylation prevents accumulation of harmful R-loops and RNA-mediated genomic instability.
Colorectal cancer patients with high levels of Thoc1 expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 expression survived longer.
In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment.
Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.
This suggests NEDD4-1 (show NEDD4 Proteins) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (show THOC2 Proteins) activity.
overexpression of hTREX84 is associated with cancer cell transformation, proliferation and may be regulated by RelA/p65 (show NFkBP65 Proteins)
We show that human THO (show THOC2 Proteins) depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and gammaH2AX (show H2AFX Proteins) and 53BP1 (show TP53BP1 Proteins) foci accumulation
A differential connection between tumorogenesis and the expression levels of human THO (show THOC2 Proteins) and ALY (show THOC4 Proteins).
hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors
Thoc1 may be important for neoplastic transformation
Results found that Thoc1 deficiency delays embryo death, and suggest that Thoc1 is required to support increased expression of E2f (show E2F1 Proteins) and apoptotic regulatory genes that trigger apoptosis upon Rb1 (show RB1 Proteins) loss.
granulocyte macrophage progenitors have a cell autonomous requirement for Thoc1 to maintain cell growth and viability
Thoc1 gene deletion prevents prostate cancer progression in mice, but has little effect on normal tissue. Prostate cancer cells deprived of Thoc1 show gene expression defects that compromise cell growth.
Thoc1 loss compromises the proliferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of differentiated cells in this rapidly renewing tissue.
results demonstrate that NO-mediated thoc1 downregulation, via Nrf2, is a key step in the cancer cell apoptosis induced by CCL-34-treated macrophages
THOC5/Fms interacting protein (show THOC5 Proteins) is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein (show THOC5 Proteins) causes the down-regulation of THOC1, which may contribute to altered THO (show THOC2 Proteins) complex function and cell death
The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described.
These findings support the notion that Thoc1-mediated RNP (show RNPC3 Proteins) assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo.
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).
THO complex subunit 1
, THO complex 1
, nuclear matrix protein p84
, THO complex subunit 1-like
, THO complex 1 protein