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Component the THO subcomplex of the TREX complex. Additionally we are shipping THO Complex 5 Antibodies (44) and many more products for this protein.
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Data suggest that the suppression of the multiple THOC5 target genes may represent a novel strategy for hepatocellular carcinoma (HCC (show FAM126A Proteins)) therapy.
THOC5 to be a novel gene involved in the regulation of serum HDL (show HSD11B1 Proteins)-C levels
Authors suggest a model in which human Thoc5 controls polyadenylation site choice through the co-transcriptional loading of CFIm68 (show CPSF6 Proteins) onto target genes.
show that THOC5 Y225 phosphorylation governs mRNA binding. In addition, CXCL12 (show CXCL12 Proteins) is shown to induce THOC5 Y225 phosphorylation, and site-directed mutagenesis demonstrates that this modulates motile response
show here that DNA damage drastically decreased the cytoplasmic pool of a set of THOC5-dependent mRNAs and impaired the THOC5/mRNA complex formation
THOC5 protein expression can potentiate receptor signalling to transcription factor expression and monocyte differentiation.
THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly.
Thoc5 exhibits in vitro RNA-binding activity and is associated with HSP70 (show HSP70 Proteins) mRNPs in vivo as a component of the stable THO (show THOC2 Proteins) complex
These results imply that murine leukemia virus requires UAP56 (show DDX39B Proteins), THOC5 and THOC7 (show THOC7 Proteins), in addition to NXF1 (show NXF1 Proteins), for nuclear export of viral transcripts.
THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt (show WNT2 Proteins)) target mRNAs and integrity of the gut (show GUSB Proteins) epithelial barrier.
Regulation of immediate-early (show JUN Proteins) gene response by THOC5, a member of mRNA export complex contributes to the M-CSF (show CSF1R Proteins)-induced macrophage differentiation.
THOC5 may be required for mRNA export under stress and/or upon signaling-induced conditions
THOC5/Fms interacting protein is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein causes the down-regulation of THOC1 (show THOC1 Proteins), which may contribute to altered THO (show THOC2 Proteins) complex function and cell death
Wild-type FMIP and FMIPSS5,6AA inhibited M-CSF (show CSF1R Proteins)-mediated survival signaling, while FMIPSS5,6EE-expressing cells survived and differentiated into macrophages more efficiently than wild-type cells in the presence of M-CSF (show CSF1R Proteins) or TPA (show PLAT Proteins)
FMIP influences the differentiation of C/EBP alpha (show CEBPA Proteins) gene during adipocyte differentiation of multipotent C2C12 cells.
Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity).
THO complex subunit 5 homolog
, protein C22orf19
, THO complex 5
, THO complex subunit 5 homolog-like
, Fms-interacting protein
, NF2/meningioma region protein pK1.3
, functional spliceosome-associated protein 79
, placental protein 39.2
, Fms interacting protein
, fms-interacting protein
, serum/glucocorticoid regulated kinase 2