TNNI3 Interacting Kinase Proteins (TNNI3K)

Human TNNI3 Interacting Kinase (TNNI3K) interaction partners

1. results suggest that ACE2, TNNI3K and CALM3 polymorphisms are associated with increased risk of hypertrophic cardiomyopathies and dilated cardiomyopathies and may act as disease modifiers of these diseases.

2. A splice site mutation of TNNI3 Interacting Kinase (TNNI3K) was identified and co-segregated with the dilated cardiomyopathy (DCM) and cardiac conduction disease (CCD (show RUNX2 Proteins)) affected family members.

3. TNNI3K overexpression promoted mouse embryonic stem cells differentiating into beating cardiomyocytes and induced up-regulating expression of cTnT (show TNNT2 Proteins) by PKCepsilon (show PRKCE Proteins) signal pathway

4. using novel genetic animal models and newly developed small-molecule TNNI3K inhibitors, we demonstrated that TNNI3K-mediated IR injury occurs through impaired mitochondrial function and is in part dependent on p38 MAPK (show MAPK14 Proteins).

5. we demonstrate that mutation of TNNI3K, encoding a heart-specific kinase known to modulate murine cardiac conduction and myocardial function, underlies a familial syndrome of electrical and myopathic heart disease in humans.

6. TNNI3K mediates cell signaling to modulate cardiac response to stress.

7. Results suggest that TNNI3K overexpression induces cardiomyocytes hypertrophy and accelerates hypertrophy in hypertrophic cardiomyocytes.

8. The finding of a de novo mutation in TNNI3 (show TNNI3 Proteins) (R204H) enabled a genetic diagnosis and counselling. We suggest that the previously reported overlap of functional and morphologic phenotypes in sarcomeric genes may also be a feature of TNNI3 (show TNNI3 Proteins) mutations.

9. [review] TNNI3K is a novel cardiac troponin I-interacting kinase gene that may be involved in the development of cardiac hypertrophy.

10. cloning of TNNI3K which interacts specifically with cardiac troponin I (show TNNI3 Proteins); data suggest that TNNI3K is a cardiac-specific kinase and plays important roles in the cardiac system

Mouse (Murine) TNNI3 Interacting Kinase (TNNI3K) interaction partners

1. using novel genetic animal models and newly developed small-molecule TNNI3K inhibitors, we demonstrated that TNNI3K-mediated IR injury occurs through impaired mitochondrial function and is in part dependent on p38 MAPK (show MAPK14 Proteins).

2. Our data provide the first evidence for a role of Tnni3k in controlling the electrocardiographic PR interval indicating a function of Tnni3k in atrio-ventricular conduction

3. Data identified Tnni3k, Fpgt (show FPGT Proteins) and H28 (show IFI44L Proteins) as likely likely candidates for Vms1.

4. Tnni3k plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention.