TRAF-Interacting Protein with Forkhead-Associated Domain Proteins (TIFA)

Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Additionally we are shipping TIFA Antibodies (43) and many more products for this protein.

list all proteins	Gene Name	GeneID	UniProt
	TIFA	92610	Q96CG3
	TIFA	211550	Q793I8
Rat TIFA	TIFA	310877	Q5XIB9

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Top TIFA Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3123994	Escherichia coli (E. coli)	Mouse	His tag	1 mg	Log in to see	30 to 35 Days	$5,465.26	Details
ABIN3074236	Insect Cells	Human	His tag	1 mg	Log in to see	50 Days	$6,869.04	Details
ABIN1322759	Wheat germ	Human	GST tag	10 μg	Log in to see	11 to 12 Days	$414.29	Details
ABIN668024	Escherichia coli (E. coli)	Human	His tag	50 μg	Log in to see	15 to 19 Days	$492.31	Details
ABIN1511837	Yeast	Xenopus tropicalis	His tag	1 mg	Log in to see	60 to 71 Days	$2,414.50	Details
ABIN1622654	Yeast	Xenopus laevis	His tag	1 mg	Log in to see	60 to 71 Days	$2,418.17	Details
ABIN1460434	Yeast	Cow	His tag	1 mg	Log in to see	60 to 71 Days	$2,440.17	Details

TIFA Proteins by Origin and Source

Origin	Expressed in	Conjugate
Human	, ,	,
Mouse (Murine)

More product categories related to TIFA Protein

More Proteins for TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) Interaction Partners

Human TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) interaction partners

TIFA (show IL22 Proteins) may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA (show IL22 Proteins) may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins.
TIFA (show IL22 Proteins) is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 (show NLRP3 Proteins) inflammasome via augmenting signals 1 and 2
study revealed that host TIFA (show IL22 Proteins) and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells
These results define TIFA (show IL22 Proteins) as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth.
we report that Aurora A (show AURKA Proteins) is essential for phosphorylation of the TRAF-interacting protein (show TANK Proteins) TIFA (show IL22 Proteins)
This study reports the crystal structures of TIFA (show IL22 Proteins) (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15).
an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate.
identify a novel threonine phosphorylation site on TIFA (show IL22 Proteins) and show that this phosphorylated threonine binds with the FHA (show CRY2 Proteins) domain of TIFA (show IL22 Proteins), leading to TIFA (show IL22 Proteins) oligomerization and TIFA (show IL22 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation
TIFA (show IL22 Proteins) induces the oligomerization and polyubiquitination of TRAF6 (show TRAF6 Proteins), which leads to the activation of TAK1 (show MAP3K7 Proteins) and IKK (show CHUK Proteins) through a proteasome-independent mechanism

Mouse (Murine) TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) interaction partners

The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins)-dependent signaling, leading to NF-kappaB (show NFKB1 Proteins) activation and HMGB1 (show HMGB1 Proteins) release
TIFA is likely to mediate IRAK-1 (show IRAK1 Proteins)/TRAF6 (show TRAF6 Proteins) interaction upon IL-1 (show IL1A Proteins) stimulation
We propose that ZCCHC11 (show ZCCHC11 Proteins) is a unique TLR signal regulator, which interacts with TIFA after LPS (show TLR4 Proteins) treatment and suppresses the TRAF6 (show TRAF6 Proteins)-dependent activation of NF-kappaB (show NFKB1 Proteins).

TIFA Protein Profile

Protein Summary

Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity).

Gene names and symbols associated with TIFA

TRAF interacting protein with forkhead associated domain (TIFA)
TRAF-interacting protein with forkhead-associated domain (tifa)
TRAF-interacting protein with forkhead-associated domain (Tifa)
TRAF-interacting protein with forkhead-associated domain S homeolog (tifa.S)

Ab2-389 protein
T2bp protein
T6BP protein
TIFA protein
TIFAA protein
xtifa protein

Protein level used designations for TIFA

TRAF-interacting protein with forkhead-associated domain , TRAF-interacting protein with a forkhead-associated domain , TRAF-interacting protein with FHA domain-containing protein A , TRAF6-binding protein , TRAF2 binding protein , TRAF2-binding protein , TRAF6 binding protein , putative MAPK-activating protein PM14 , putative NF-kappa-B-activating protein 20 , Traf2 binding protein

GENE ID	SPECIES
422692	Gallus gallus
471278	Pan troglodytes
487905	Canis lupus familiaris
100216213	Xenopus (Silurana) tropicalis
92610	Homo sapiens
211550	Mus musculus
310877	Rattus norvegicus
783855	Bos taurus
734184	Xenopus laevis

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