Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) ELISA Kits

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Antibodies (64) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TNKS 8658 O95271
TNKS 21951 Q6PFX9
Anti-Rat TNKS TNKS 290794  
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Top Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase ELISA Kits at antibodies-online.com

Showing 7 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.115 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days
$736.84
Details
Monkey 0.188 ng/mL 0.313-20 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Rabbit 75 pg/mL 125-8000 pg/mL   96 Tests 12 to 14 Days
$715.00
Details
Pig 0.188 ng/mL 0.313-20 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Chicken 0.188 ng/mL 0.313-20 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Human 37.5 pg/mL 62.5 pg/mL - 4000 pg/mL Typical standard curve 96 Tests 12 to 14 Days
$715.00
Details
Mouse
  96 Tests 15 to 18 Days
$875.60
Details

More ELISA Kits for Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Interaction Partners

Zebrafish Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. findings identified TNKS as an oncogenic regulator of ovarian cancer cells proliferation that promotes aerobic glycolysis via activation of Wnt/beta-catenin signaling.

  2. The dimer is weak and may only form in the context of the sterile alpha motif (SAM) domain-mediated oligomers of TNKS, consistent with the dependence of the TNKS activity on the SAM domain.

  3. Either tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telomere cohesion and maintain mitotic spindle integrity. Tankyrases are required for Notch2 to exit the plasma membrane and enter the nucleus to activate transcription.

  4. Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS enzyme activities.

  5. The data indicate that the sterile alpha motif domain polymerization is critical for TNKS1 catalytic activity and allows TNKS1 to efficiently access cytoplasmic signaling complexes.

  6. Polymerization is required for Tankyrase to drive beta-catenin-dependent transcription. The polymeric state supports PARP activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN binding.

  7. In late S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex.

  8. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  9. Results describe the structure of three consecutive TNKS- ankyrin repeat clusters (ARCs). Binding analysis indicates specific ARC pairs engage bivalent binding partner Axin1, and that both rigid and flexible ARC connections form an adaptable TNKS binding platform.

  10. we show for the first time that Tankyrase 1 inhibitior XAV939 was able to significantly increase the apoptosis induced by 5-FU/DDP, accompanied by the protein expression level alternation of b-catenin, Axin and CSC markers in colon cancer cells.

  11. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2.

  12. HCMV modulates the activity of TNKS to induce Axin1, resulting in inhibition of the beta-catenin pathway.

  13. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt/beta-catenin signaling addicted tumors.

  14. TNKS1 SNPs (rs11991621 rs10503380, and rs7015700) were associated with non-small cell lung cance risk, whereas rs6601328 and rs12541709 inversely associated with risk

  15. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC with aberrant WNT/beta-catenin signaling pathway.

  16. TNKS1 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks.

  17. Copy number deletion on TNKS was associated with a 1.37-fold decreased risk for osteoarthritis.

  18. tankyrase-mediated PARsylation is promoted by nutritional energy stimulated NAD+ in insulinoma cells

  19. Data indicate that tankyrase (Tnks) inhibitors impact telomere length maintenance independently of their affects on Wnt/beta-catenin signaling.

  20. We demonstrate for the first time that tankyrase inhibition triggers reduced cell growth and differentiation of OS cells

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. Study using Villin-creERT2;Tnks1-/-;Tnks2fl/fl mice, which harbored conventional Tnks1 deletion and inducible intestinal epithelium-specific Tnks2 knockout, shows that tankyrases regulate adult intestinal Lgr5+ stem cells and epithelium homeostasis by preventing cell death and promoting cell proliferation.

  2. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

  3. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  4. analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt/beta-catenin signaling

  5. Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands.

  6. Collectively, our data suggest that GSK3 contributes to mitotic tankyrase phosphorylation.

  7. insulin-stimulated insulin-responsive aminopeptidase translocation remained intact despite substantial GLUT4 knockdown

  8. tankyrase1 is a poly(ADP-ribose) polymerase with roles in telomere length control by the TRF1 component of the shelterin complex

  9. Tankyrase 1 is essential but redundant for mouse embryonic development

  10. Tankyrase-deficient mice exhibit increases in energy expenditure, fatty acid oxidation, and insulin-stimulated glucose utilization.

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) Antigen Profile

Antigen Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Gene names and symbols associated with TNKS

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b (tnksb) antibody
  • tankyrase (TNKS) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (Tnks) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 S homeolog (tnks2.S) antibody
  • tankyrase (Tnks) antibody
  • 4930554K12Rik antibody
  • AI662855 antibody
  • ARTD5 antibody
  • C86528 antibody
  • D130072O21Rik antibody
  • mTNKS1 antibody
  • PARP-5a antibody
  • PARP5A antibody
  • PARPL antibody
  • pART5 antibody
  • TANK1 antibody
  • tankyrase-1 antibody
  • TIN1 antibody
  • TINF1 antibody
  • TNKS1 antibody
  • wu:fe02c12 antibody

Protein level used designations for TNKS

fe02c12 , tankyrase 1 , ADP-ribosyltransferase diphtheria toxin-like 5 , TANK1 , TNKS-1 , TRF1-interacting ankyrin-related ADP-ribose polymerase , poly [ADP-ribose] polymerase 5A , tankyrase I , tankyrase-1 , TRF1-interacting ankyrin-related ADP-ribose polymerase 1

GENE ID SPECIES
567533 Danio rerio
8658 Homo sapiens
21951 Mus musculus
100036993 Xenopus laevis
374252 Gallus gallus
475603 Canis lupus familiaris
535030 Bos taurus
290794 Rattus norvegicus
100153228 Sus scrofa
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