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Probable adapter protein involved in signaling pathways.
Showing 5 out of 6 products:
TOM1L1 enhances ERBB2 (show ERBB2 Proteins)-induced cell invasiveness by promoting invadopodia formation and MT1-MMP (show MMP14 Proteins) trafficking to the plasma membrane.
whereas TOM1L1 depletion only slightly affected SRC (show SRC Proteins)-induced proliferation of colorectal cancer cells in vitro, it drastically decreased tumor growth in xenografted nude mice.
This pattern of Srcasm expression suggests that it may act as a negative regulator in esophageal squamous cell carcinoma cell signaling
results imply that TOM1L has a mitogenic effect in Jurkat T-cells and is involved in a novel cell signaling pathway that is crucial for the IL-2 (show IL2 Proteins) production and STAT3 (show STAT3 Proteins) expression
Srcasm plays a role in linking EGF receptor (show EGFR Proteins)- and SFK-dependent signaling to differentiation in keratinocytes
Tom1L1 could act as an intermediary between signaling and degradative pathways.
study found that not only the PTAP sequence in the GAT (show GLYAT Proteins) domain but also the PSAP (show PSAP Proteins) sequence in the C-terminal region of Tom1L1 is responsible for its interaction with the UEV domain of Tsg101 (show TSG101 Proteins) and competes with the HIV-1 Gag protein for the Tsg101 (show TSG101 Proteins) interaction
All multicentric and nodular basal cell carcinomas displayed a prominent loss of Srcasm staining in association with a marked increase in Ki-67 (show MKI67 Proteins) staining.
Participation of Tom1L1 in EGF (show EGF Proteins)-stimulated endocytosis of EGF receptor (show EGFR Proteins).
Tom1L1 defines a novel mechanism for regulation of Src (show SRC Proteins) family of protein-tyrosine kinases mitogenic signaling induced by growth factors.
Srcasm may act as a molecular "rheostat" for activated Src (show SRC Proteins) family tyrosine kinases
Tom1L1-clathrin heavy chain (CHC) complex negatively regulates the level of SFK in caveolae needed for the induction of DNA synthesis.
Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promotes FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).
target of myb1-like 1
, target of myb1 (chicken)-like 1
, TOM1-like protein 1
, TOM1-like protein 1-like
, Src activating and signaling molecule
, src-activating and signaling molecule protein
, target of Myb-like protein 1
, target of myb 1-like 1
, Src-activating and signaling molecule protein
, Target of Myb-like protein 1
, Jerry protein