Taste Receptor, Type 1, Member 2 Proteins (TAS1R2)

Putative taste receptor. Additionally we are shipping Taste Receptor, Type 1, Member 2 Antibodies (75) and Taste Receptor, Type 1, Member 2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAS1R2 80834 Q8TE23
Rat TAS1R2 TAS1R2 100270683 Q9Z0R7
TAS1R2 83770 Q925I4
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Top Taste Receptor, Type 1, Member 2 Proteins at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,639.51
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

TAS1R2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
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Mouse (Murine) ,
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More Proteins for Taste Receptor, Type 1, Member 2 (TAS1R2) Interaction Partners

Human Taste Receptor, Type 1, Member 2 (TAS1R2) interaction partners

  1. We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface between TMDs of TAS1R2 and TAS1R3 (show TAS1R3 Proteins), which is consistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 (show GRM2 Proteins) homodimer.

  2. Alleles from each TAS1R2 locus (GG compared with AA alleles of rs12033832, and CT/CC compared with TT alleles of rs35874116) were related to higher consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively (P<0.05).

  3. The molecular anatomy of sweet taste receptor dimers T1R2-T1R3 (show TAS1R3 Proteins) has been presented.

  4. no significant associations between GLUT2 (show SLC2A2 Proteins) and/or TAS1R2 polymorphisms and fillings were found, but allele frequencies of the TAS1R2 variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. no significant interaction between both genes and risk of dental caries was found. GLUT2 (show SLC2A2 Proteins) and TASR1 (show SRSF10 Proteins) polymorphisms may influence the risk of caries in the Czech population

  5. In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.

  6. high-risk caries experience (>8 caries) was found to be associated with TAS1R2 rs35874116 homozygous polymorphic genotype.

  7. The rs12033832 single nucleotide polymorphism in TAS1R2 is associated with sucrose taste and sugar intake, but the effect differs depending on BMI

  8. human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 (show TAS1R3 Proteins)

  9. effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 (show TAS1R3 Proteins)

  10. Interaction between brazzein and the amino terminal domain of the sweet receptor subunit T1R2 showed a stronger interaction at 7 degrees C than at 37 degrees C.; the low temperature conformation, alters the orientations of 2 loops known to be critical for the sweetness of brazzein, may represent the bound state of brazzei in the complex with the human sweet receptor.

Mouse (Murine) Taste Receptor, Type 1, Member 2 (TAS1R2) interaction partners

  1. Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 (show TAS1R3 Proteins) and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk (show CTSK Proteins) during osteoclast differentiation. (Ctsk (show CTSK Proteins) = cathepsin K (show CTSK Proteins))

  2. mice lacking T1R2 + T1R3 (show TAS1R3 Proteins) and controls were tested in a taste discrimination task to determine whether maltodextrins are 1 (show VPS52 Proteins)) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3 (show TAS1R3 Proteins).

  3. results implicate each subunit of the T1R2+T1R3 (show TAS1R3 Proteins) dimer in the behavioral response to P-containing taste compounds

  4. T1R2 plays an important role in glucose homeostasis during diet-induced obesity through the regulation of yet to be identified molecular mechanisms that alter energy disposal and utilization in peripheral tissues. T1r2 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance.

  5. Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2+T1r3 (show TAS1R3 Proteins). The other mediates cephalic phase insulin (show INS Proteins) release but does not require an intact T1r2+T1r3 (show TAS1R3 Proteins).

  6. human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 (show TAS1R3 Proteins)

  7. T1R2 and T1R3 (show TAS1R3 Proteins) knockout mice have increased cortical bone mass and trabecular remodeling.

  8. effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 (show TAS1R3 Proteins)

  9. T1R2+3 heterodimer is the principal receptor that mediates taste detection of natural sweeteners, but not of all carbohydrate stimuli.

  10. Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin (show INS Proteins) release and its potentiating effects on glucose-stimulated insulin (show INS Proteins) secretion in vitro and in vivo.

Taste Receptor, Type 1, Member 2 (TAS1R2) Protein Profile

Protein Summary

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity).

Gene names and symbols associated with TAS1R2

  • taste 1 receptor member 2 (TAS1R2)
  • taste 1 receptor member 2 (Tas1r2)
  • taste receptor, type 1, member 2 (Tas1r2)
  • Aldh4a1 protein
  • Gpr71 protein
  • T1r2 protein
  • Tr2 protein

Protein level used designations for TAS1R2

taste receptor type 1 member 2 , G protein-coupled receptor 71 , G-protein coupled receptor 71 , sweet taste receptor T1R2 , aldehyde dehydrogenase 4 family, member A1 , taste receptor TR2 , candidate taste receptor T1R2

GENE ID SPECIES
529847 Bos taurus
80834 Homo sapiens
100270683 Rattus norvegicus
83770 Mus musculus
478213 Canis lupus familiaris
714666 Macaca mulatta
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