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Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Additionally we are shipping and many more products for this protein.
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demonstrate that Lys117, an important CRAC residue, is crucial in the reported cholesterol sensitivity of T2R4. Interestingly, cholesterol sensitivity of T2R4 was observed at quinine concentrations in the lower mM range.
This study is the first to show an inhibitory downstream action of a T2R4 agonist on Rac1 function.
Data indicate that KLK/R motif in C-terminus performs functional role in bitter taste receptor T2R4 signaling.
The antagonist ability of ABA was tested using another T2R4 agonist, yohimbine. Our results suggest that ABA does not inhibit yohimbine-induced T2R4 activity.
Data indicate that the itter blockers and agonists share the same orthosteric site in bitter taste receptor T2R4.
these results show that rhodopsin N-terminal 33 amino acids enhance expression of T2R4 by 2.5-fold and do not cause perturbations in the receptor structure.
This study demonistrated that human TAS2R4 play the role of food preference behavior.
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
candidate taste receptor T2R4
, taste receptor type 2 member 4
, taste receptor T2R4
, bitter taste receptor Bota-T2R4
, taste receptor, type 2, member 4