anti-Taurine Transporter (TAUT) Antibodies

Mouse (Murine) Taurine Transporter (TAUT) interaction partners

1. Circulating levels of GDF15 were elevated in old slc6a6 knockout mice

2. These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle.

3. This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin secretion.

4. both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease

5. This study demonistrated that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation.

6. Studied protective effect of taurine associated with the upregulation of TAUT expression in acute myocardial ischemia. Data showed that taurine reversed the apoptosis induced by hypoxia and AMI, thereby, effectively protecting the myocardium.

7. Acute exposure to ROS reduces taurine uptake as a result of modulated TauT transport kinetics.

8. Effective T-cell recall responses require the taurine transporter Taut.

9. study represents the first characterization of TauT in neural precursor cells

10. data suggest TauT plays a critical role in renal function; expression of TauT is negatively regulated by p53 and positively regulated by c-Jun; outcome level of TauT may determine the fate of renal cells during stress-induced acute kidney injury

11. All taut-/- mice succumb to infections during crisis, while about 90% of the control taut(+/+) mice survive.

12. The retinal involvement identifies the taurine transporter as an important factor for the development and maintenance of normal retinal functions and morphology.

13. decreased sensitivity of mature erythrocytes from taut-/- mice to osmotic shock and oxidative stress, rendering them more resistant to apoptosis

14. Knockout of the taurine transporter identifies taurine transport as a crucial factor for the maintenance of skeletal muscle function and total exercise capacity, while cardiac muscle apparently can compensate for the loss of taurine.

15. in NIH3T3 cells active taurine uptake reflects TauT expression TauT activity is modulated by multiple stimuli; the subcellular localization of TauT is regulated; and volume-sensitive taurine release is not mediated by TauT

16. Murine TAUT is regulated in response to hypertonicity and taurine-rich conditions.

17. TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts

18. Taut-/- mice suffer from renal taurine loss and impaired ability to lower urine osmolality and to increase urinary water excretion.

19. Apoptotic liver damage develops as a consequence of taurine deficiency due to taurine transporter knockout mutation.

20. TAUT is responsible for taurine uptake in mouse cerebrocortical neurons, and that the expression of TAUT is increased with developing cerebrocortical neurons

Cow (Bovine) Taurine Transporter (TAUT) interaction partners

1. Results indicate that the gene expressions of TauT and cyclin C are cooperatively regulated under hypotonic conditions.

Human Taurine Transporter (TAUT) interaction partners

1. TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine.

2. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy

3. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells.

4. Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells.

5. Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface.

6. Taurine transporter is a novel pathological marker for stressed motor neurons in amyotrophic lateral sclerosis.

7. Taurine transporter deficiency results in aberrant trophoblast turnover and fetal growth restriction.

8. Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy.

9. Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.

10. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes.

11. TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients.

12. TNF-alpha-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells.

13. TauT is involved with p53 in renal development and apoptosis.

14. regulation by WT1

15. nitric oxide plays an important role in downregulating microvillous plasma membrane taurine transporter activity in intrauterine growth restriction

16. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor.

17. TAUT activity in TNF-alpha-treated Caco-2 cells suggests that up-regulation was associated with an increase in the amount of TAUT.

18. reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region

19. taurine cotransporter is regulated by oxidative stress and overexpression of aldose reductase and high glucose impair this response

20. Greater system beta activity in fetal platelets compared with T lymphocytes is the result of relatively greater TAUT mRNA and protein expression.