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Circulating levels of GDF15 were elevated in old slc6a6 knockout mice
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These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle.
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This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin secretion.
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both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease
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This study demonistrated that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation.
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Studied protective effect of taurine associated with the upregulation of TAUT expression in acute myocardial ischemia. Data showed that taurine reversed the apoptosis induced by hypoxia and AMI, thereby, effectively protecting the myocardium.
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Acute exposure to ROS reduces taurine uptake as a result of modulated TauT transport kinetics.
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Effective T-cell recall responses require the taurine transporter Taut.
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study represents the first characterization of TauT in neural precursor cells
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data suggest TauT plays a critical role in renal function; expression of TauT is negatively regulated by p53 and positively regulated by c-Jun; outcome level of TauT may determine the fate of renal cells during stress-induced acute kidney injury
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All taut-/- mice succumb to infections during crisis, while about 90% of the control taut(+/+) mice survive.
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The retinal involvement identifies the taurine transporter as an important factor for the development and maintenance of normal retinal functions and morphology.
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decreased sensitivity of mature erythrocytes from taut-/- mice to osmotic shock and oxidative stress, rendering them more resistant to apoptosis
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Knockout of the taurine transporter identifies taurine transport as a crucial factor for the maintenance of skeletal muscle function and total exercise capacity, while cardiac muscle apparently can compensate for the loss of taurine.
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in NIH3T3 cells active taurine uptake reflects TauT expression TauT activity is modulated by multiple stimuli; the subcellular localization of TauT is regulated; and volume-sensitive taurine release is not mediated by TauT
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Murine TAUT is regulated in response to hypertonicity and taurine-rich conditions.
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TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts
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Taut-/- mice suffer from renal taurine loss and impaired ability to lower urine osmolality and to increase urinary water excretion.
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Apoptotic liver damage develops as a consequence of taurine deficiency due to taurine transporter knockout mutation.
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TAUT is responsible for taurine uptake in mouse cerebrocortical neurons, and that the expression of TAUT is increased with developing cerebrocortical neurons