Tensin 4 Proteins (TNS4)

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3 (By similarity). Additionally we are shipping Tensin 4 Antibodies (43) and Tensin 4 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNS4 84951 Q8IZW8
TNS4 217169 Q8BZ33
TNS4 303517 Q4V8I3
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Top Tensin 4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$4,051.67
Details

TNS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Tensin 4 (TNS4) Interaction Partners

Human Tensin 4 (TNS4) interaction partners

  1. Cten may play an essential role in mediating TGF-beta1-induced EMT and cell motility and may therefore play a role in metastasis in colorectal cancer.

  2. induction of CTEN reactivates focal adhesion kinase (FAK) Y(397) phosphorylation and disrupts the acini structure.

  3. CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells.

  4. Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1.

  5. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein.

  6. Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3.

  7. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma

  8. Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3.

  9. Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients.

  10. Up-regulated cten modulates cell migration induced by FGF2.

  11. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer.

  12. CTEN regulates EGFR protein levels through a posttranslational mechanism.

  13. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene.

  14. Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility.

  15. conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility

  16. Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis.

  17. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma.

  18. Increased cten mRNA expression was correlated with tumor progression in lung cancers

  19. Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma.

  20. These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity.

Tensin 4 (TNS4) Protein Profile

Protein Summary

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3 (By similarity). Cytoplasm, cytoskeleton (By similarity).

Gene names and symbols associated with Tensin 4 Proteins (TNS4)

  • tensin 4 (TNS4)
  • tensin 4 (Tns4)
  • 9930017A07Rik protein
  • AA589547 protein
  • AU016405 protein
  • Cten protein
  • RGD1310402 protein
  • TNS4 protein

Protein level used designations for Tensin 4 Proteins (TNS4)

tensin 4 , C-terminal tensin-like , tensin-4-like , C terminal tensin like , C-terminal tensin-like protein , tensin-4

GENE ID SPECIES
454653 Pan troglodytes
491012 Canis lupus familiaris
701075 Macaca mulatta
100015920 Monodelphis domestica
100054186 Equus caballus
100412834 Callithrix jacchus
100585687 Nomascus leucogenys
84951 Homo sapiens
217169 Mus musculus
303517 Rattus norvegicus
532898 Bos taurus
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