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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Additionally we are shipping TESK1 Proteins (8) and many more products for this protein.
Showing 10 out of 37 products:
Human Monoclonal TESK1 Primary Antibody for ELISA, WB - ABIN563149
Chandramouli, Yu, Yusoff, Lao, Leong, Mizuno, Guy: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. in The Journal of biological chemistry 2008
Actin remodelling factor TESK1 is a key player in the ciliogenesis control network in which YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) and directional vesicle trafficking are integral components.
The absence of GSTM1 (show GSTM1 Antibodies) and GSTT1 (show GSTT1 Antibodies) genes increases the risk of lung cancer because of radon exposure.
the absence of GSTM1 (show GSTM1 Antibodies) activity can be compensated for by the overexpression of GSTM2 (show GSTM2 Antibodies).
demonstrated that the GSTM1 (show GSTM1 Antibodies) and GSTT1 (show GSTT1 Antibodies) null genotype may be associated with an increased risk of Hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and that individuals having the combination of both defective GST (show SLCO6A1 Antibodies) genotypes may be more susceptible to developing HCC (show FAM126A Antibodies)
High expression of GSTM1 (show GSTM1 Antibodies) and GSTM4 (show GSTM4 Antibodies), along with increased endogenous reduced glutathione levels, help to maintain a more reduced state of cytochrome c (show CYCS Antibodies) which decreases apoptosis thus contributing to methotrexate resistance in human MCF7 breast cancer cells.
GST-M2 exhibited high frequency of promoter hypermethylation in lung cancer cells, CpG hypermethylation abated Sp1 binding to the GST-M2 promoter in lung cancer
it was noted that the alpha-6 helix of GST-C plays a stabilising role in the fold of this domain. By destabilising the conformation of GST-C, an increase in cell translocation efficiency of up to approximately 2-fold was observed.
analysis of active-site residues and modulation of catalytic functions in GST-M2
High GSTM2 (show GSTM2 Antibodies) is associated with mesenchymal stem-like cells derived from ovarian teratoma (show DND1 Antibodies).
it is unlikely that glutathione S-transferases GSTA2 (show GSTa2 Antibodies), GSTM2 (show GSTM2 Antibodies), GSTO1 (show GSTO1 Antibodies), GSTO2 (show GSTO2 Antibodies), and GSTZ1 (show GSTZ1 Antibodies) participate in breast cancer susceptibility.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
dual specificity testis-specific protein kinase 1
, testicular protein kinase 1
, GST class-mu 2
, GST, muscle
, S-(hydroxyalkyl)glutathione lyase M2
, glutathione S-alkyltransferase M2
, glutathione S-aralkyltransferase M2
, glutathione S-aryltransferase M2
, glutathione S-transferase 4
, glutathione S-transferase M1
, glutathione S-transferase M2 (muscle)
, glutathione S-transferase Mu 2
, testis specific protein kinase 1
, testis-specific kinase 1
, testis-specific protein kinase 1
, dual specificity testis-specific protein kinase 1-like