Thiamin Pyrophosphokinase 1 Proteins (TPK1)

TPK1 encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Additionally we are shipping TPK1 Antibodies (49) and TPK1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPK1 27010 Q9H3S4
Rat TPK1 TPK1 680668  
TPK1 29807 Q9R0M5
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Top TPK1 Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
Details
Human Cells Human His tag   50 μg Log in to see 4 Days
$313.50
Details
Escherichia coli (E. coli) Human His tag Human TPK1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$217.80
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 14 to 16 Days
$311.24
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Human Cells Human His tag   10 μg Log in to see 15 to 16 Days
$212.50
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 60 to 71 Days
$2,619.83
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,619.83
Details

TPK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Top referenced TPK1 Proteins

  1. Human TPK1 Protein expressed in HEK-293 Cells - ABIN2733558 : Zhang, Zhang, Diamond, Boer, Harris, Li, Rupar, Behshad, Gardiner, Collier, Liu, Burn, Wynn, Hollis, Yeleswaram: The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy. in Drug metabolism and disposition: the biological fate of chemicals 2014 (PubMed)

More Proteins for Thiamin Pyrophosphokinase 1 (TPK1) Interaction Partners

Maize/Corn (Zea mays) Thiamin Pyrophosphokinase 1 (TPK1) interaction partners

  1. TPK was the 29-kDa monomeric protein, with the optimal activity at pH 9.0, the K(m) values of 12.4microM and 4.7mM for thiamine and ATP, respectively, and the V(max) value of 360pmol TDPmin(-1)mg(-1) protein

Caenorhabditis elegans (C. elegans) Thiamin Pyrophosphokinase 1 (TPK1) interaction partners

  1. stress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animals

Human Thiamin Pyrophosphokinase 1 (TPK1) interaction partners

  1. any disease mutants are directly or indirectly involved in thiamine binding. Thus, our study provided a novel rationale for thiamine supplementation, so far the major therapeutic intervention in TPK deficiency.

  2. These findings demonstrate that the genes involved in dictating thiamine homeostasis, such as SLC19A2, SLC25A19 and TPK-1, were significantly up-regulated in clinical tissues and breast cancer cell lines.

  3. Mutation analysis of TPK1 uncovered three missense, one splice-site, and one frameshift mutation resulting in decreased TPK protein levels

  4. findings indicate the importance of the Sp1 transcription factor cis-element in regulating the human thiamin pyrophosphokinase gene (hTPK1) gene expression

  5. Genomic variations in either the fetal or maternal TPK1 gene could contribute to variability of birth weight in normal humans.

  6. This is the first report on the primary sequence for mammalian thiamin pyrophosphokinase, a protein that catalyzes the pyrophosphorylation of thiamin with adenosine 5'-triphosphate to form thiamin pyrophosphate.

Mouse (Murine) Thiamin Pyrophosphokinase 1 (TPK1) interaction partners

  1. Three-dimensional structure of thiamine pyrophosphokinase crystallized from an equilibrium substrate/product mixture shows clear electron density for pyrithiamine pyrophosphate bound in the enzyme active site.

TPK1 Protein Profile

Protein Summary

This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with TPK1

  • thiamin pyrophosphokinase 1 (TPK1)
  • thiamin pyrophosphokinase 1 (tpk1)
  • thiamin pyrophosphokinase 1 (PVX_099630)
  • thiamin pyrophosphokinase 1 (CpipJ_CPIJ015475)
  • thiamin pyrophosphokinase 1 (MCYG_04241)
  • thiamin pyrophosphokinase 1 (LOC100285737)
  • Thiamin pyrophosphokinase 1 (tpk-1)
  • thiamin pyrophosphokinase 1 (Tpk1)
  • thiamine pyrophosphokinase (Tpk1)
  • HTPK1 protein
  • PP20 protein
  • THMD5 protein
  • tpk1 protein
  • zgc:101685 protein

Protein level used designations for TPK1

thiamin pyrophosphokinase 1 , GRMZM2G055458 , hypothetical protein , thiaminepyrophosphokinase 1 , placental protein 20 , thiamine diphosphokinase , thiamine kinase , thiamine pyrophosphokinase , thiamine pyrophosphokinase 1 , mTPK1

GENE ID SPECIES
420780 Gallus gallus
450054 Danio rerio
463818 Pan troglodytes
706237 Macaca mulatta
5474067 Plasmodium vivax Sal-1
6048703 Culex quinquefasciatus
9224574 Arthroderma otae CBS 113480
100280851 Zea mays
100285737 Zea mays
100528878 Ictalurus punctatus
176258 Caenorhabditis elegans
27010 Homo sapiens
680668 Rattus norvegicus
475515 Canis lupus familiaris
788066 Bos taurus
29807 Mus musculus
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