Thrombospondin 4 Proteins (THBS4)

The protein encoded by THBS4 belongs to the thrombospondin protein family. Additionally we are shipping Thrombospondin 4 Antibodies (61) and Thrombospondin 4 Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
THBS4 7060 P35443
THBS4 21828 Q9Z1T2
THBS4 29220  
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Top Thrombospondin 4 Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg 15 to 18 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

THBS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Thrombospondin 4 (THBS4) Interaction Partners

Human Thrombospondin 4 (THBS4) interaction partners

  1. In this review article, we summarize the properties and functions of TSP-4 and discuss its role in tissue remodeling.

  2. we report that TSP-4 is present in articular cartilage and increases dramatically in OA, where it might contribute to the maintenance of cartilage structure and function. TSP-4 levels in cartilage correlate positively with OA severity and the anchorage of TSP-4 in the matrix seems to be weaker at an early disease stage.

  3. In hepatocellular carcinoma patients, high THBS4 expression was associated with shorter overall and disease-free survival compared with low THBS4 expression.

  4. THBS4 had positive effects on gastric cancer cell proliferation, progression, and metastasis via targeting KLF9.

  5. establish a novel molecular mechanism by which miR-148a-3p upregulates Tsp-4 expression in tenocytes to promote angiogenesis by targeting KLF6, which could be helpful for the treatment of tendinopathy in the future

  6. TSP-4 A387P polymorphism, but not TSP-1 polymorphism, is an independent risk factor for acute myocardial infarction in Egyptians.

  7. Findings indicate that loss of miR-142 results in the over-expression of THBS4, which enhances HCC migration and vascular invasion.

  8. the present study demonstrates that THBS4 and lncRNA-THBS4-003 serve a significant role in PCa proliferation and migration via the MMP-9 and p38 MAPK signaling pathway.

  9. THBS2 and THBS4 mRNA are overexpressed in gastric cancer in a Southeast Chinese population.

  10. The THBS4 A387P polymorphism was associated with coronary artery disease in American population.

  11. Tsp4 functions as an ECM scaffold at myotendinous junctions, with potential therapeutic uses in tendon strengthening and repair

  12. THBS4 expression in breast cancer-associated extracellular matrix contributes to the activated stromal response exhibited during tumour progression

  13. the balancing selection target in THBS4 is likely represented by one or more variants that regulate tissue-specific and sex-specific gene expression

  14. The results of thid study suggested that injury-induced spinal TSP4 may contribute to spinal presynaptic hypersensitivity and neuropathic pain states.

  15. genetic polymorphism predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels

  16. Identify THBS4 as a powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease.

  17. High THBS4 methylation resulting in inactivation of the gene is associated with colorectal cancer.

  18. thrombospondin-4 C-terminal peptide has a role in stimulating erythroid cell proliferation

  19. Promoter hypermethylation of thrombospondin 4 is associated with cutaneous T-cell lymphoma

  20. A387P in thrombospondin-4 and N700S in thrombospondin-1 polymorphisms perturb calcium binding sites

Mouse (Murine) Thrombospondin 4 (THBS4) interaction partners

  1. Like wild-type Thbs4, a secretion-defective mutant upregulates the adaptive ER stress response and expands the ER and intracellular vesicles in cardiomyocytes. However, only the secretion-defective Thbs4 mutant produces cardiomyopathy with sarcolemmal weakness and rupture that is associated with reduced adhesion-forming glycoproteins in the membrane.

  2. TSP-4 is an important protein in the development of cardiac hypertrophy and aortic dissections in Ang II-induced hypertension.

  3. The findings demonstrate reciprocal regulation of the unfolded protein response, including ATF6alpha activation and endoplasmic reticulum expansion, and reduced contractile differentiation in bladder outlet obstruction occurring independently of thrombospondin-4, which however is a sensitive indicator of obstruction.

  4. Loss of the Thbs4 gene causes spontaneous dystrophic changes with aging and accelerates disease in 2 mouse models of muscular dystrophy, while overexpression of mouse Thbs4 is protective and mitigates dystrophic disease.

  5. TSP-4 plays a role in angiotensin II induced hypertension, affecting cardiac hypertrophy, aortic aneurysm formation, as well as endothelial-dependent relaxation in resistance arteries.

  6. This study demonstrated THAT elevated TSP4 after peripheral nerve injury may contribute to hypersensitivity of peripheral sensory systems by decreasing HVA and increasing LVA in DRG neurons by targeting the alpha2delta1 calcium subunit.

  7. Absence of Thbs4 abrogated adipose tissue inflammation and neointimal formation supporting the potential for inhibition of Thbs4 to prevent inflammatory vascular pathologies/diseases such as restenosis.

  8. present studies on the cardiac function of KLF6 show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor thrombospondin 4

  9. these data identify the critical intracellular functional domains of thrombospondin-4, which was formerly thought to have only extracellular functions

  10. TSP-4, an extracellular matrix protein previously associated with tissue remodeling, is now demonstrated to possess proangiogenic activity.

  11. This study demonistrated that Thrombospondin 4 deficiency in mouse impairs neuronal migration in the early postnatal and adult brain.

  12. thrombospondin-4 is downregulated by curcumin-induced oxidized low-density lipoprotein in mouse macrophages

  13. findings have important implications for post-injury applications of endogenous and transplanted neural stem cells in the therapeutic setting, as well as disease states where Thbs family members have important roles

  14. The expression of inflammatory and fibrotic genes known to be influential in myocardial remodeling changed as a result of TSP-4 deficiency in vivo and as a result of incubation of cells with recombinant TSP-4 in vitro.

  15. Thbs4 cardiac-specific transgenic mice were protected from myocardial injury, whereas Thbs4-/- mice were sensitized to cardiac maladaptation.

  16. TSP4 is myocyte-interstitial mechano-signaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to play a crucial role in the transition to chronic cardiac dilatation and failure.

  17. Thrombospondin-4 plays an important role in the local regulation of inflammation associated with atherogenesis.

Zebrafish Thrombospondin 4 (THBS4) interaction partners

  1. Tsp4 functions as an ECM scaffold at myotendinous junctions, with potential therapeutic uses in tendon strengthening and repair

Cow (Bovine) Thrombospondin 4 (THBS4) interaction partners

  1. Thrombospondin-4 widely distributed in bovine eye where it may play role in functions of basement membranes in various tissues. Abundant in trabecular and uveo-scleral pathways. May play role in regulation of aqueous outflow resistance.

  2. thrombospondin-4 C-terminal peptide has a role in stimulating erythroid cell proliferation

Thrombospondin 4 (THBS4) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.

Gene names and symbols associated with Thrombospondin 4 Proteins (THBS4)

  • thrombospondin 4 (THBS4)
  • thrombospondin 4 (Thbs4)
  • thrombospondin 4b (thbs4b)
  • thrombospondin 4 S homeolog (thbs4.S)
  • thrombospondin-4 (thbs4)
  • MGC79977 protein
  • thbs4 protein
  • TSP-4 protein
  • tsp4 protein
  • zgc:111910 protein

Protein level used designations for Thrombospondin 4 Proteins (THBS4)

thrombospondin-4 , Tsp-4a , thbs4-B , thrombospondin 4 , thrombospondin-4-B

7060 Homo sapiens
21828 Mus musculus
29220 Rattus norvegicus
252850 Danio rerio
446985 Xenopus laevis
541281 Bos taurus
100720036 Cavia porcellus
396306 Gallus gallus
100513005 Sus scrofa
100357137 Oryctolagus cuniculus
397943 Xenopus laevis
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