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THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Additionally we are shipping THEMIS Proteins (4) and THEMIS Kits (1) and many more products for this protein.
Showing 10 out of 92 products:
Human Monoclonal THEMIS Primary Antibody for WB - ABIN2689927
Fu, Vallée, Rybakin, McGuire, Ampudia, Brockmeyer, Salek, Fallen, Hoerter, Munshi, Huang, Hu, Fox, Sauer, Acuto, Gascoigne: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. in Nature immunology 2009
Show all 4 Pubmed References
Human Polyclonal THEMIS Primary Antibody for IHC, IHC (p) - ABIN4359153
Paster, Bruger, Katsch, Grégoire, Roncagalli, Fu, Gascoigne, Nika, Cohnen, Feller, Simister, Molder, Cordoba, Dushek, Malissen, Acuto: A THEMIS:SHP1 complex promotes T-cell survival. in The EMBO journal 2015
Mouse (Murine) Polyclonal THEMIS Primary Antibody for ELISA, WB - ABIN4359167
Lesourne, Uehara, Lee, Song, Li, Pinkhasov, Zhang, Weng, Wildt, Wang, Bosselut, Love: Themis, a T cell-specific protein important for late thymocyte development. in Nature immunology 2009
we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4 (show CD4 Antibodies)+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms
we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.
the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.
THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.
THEMIS binding to GRB2 (show GRB2 Antibodies) was required for thymocyte development.
SPOP (show SPOP Antibodies) mutations may define a new molecular subtype of prostate cancer.
specific role for THEMIS in early TCR signalosome function
Functional characterization of the homologous mouse gene.
Functional analysis of the mouse gene by knockout, and comparison of the mouse a (show PTCRA Antibodies)nd human proteins.
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 (show VAV1 Antibodies) activity and Grb2 (show GRB2 Antibodies) stability
the positive selection of immature CD4 (show CD4 Antibodies)+CD8 (show CD8A Antibodies)+ double-positive thymocytes and their commitment to the CD4 (show CD4 Antibodies)+CD8 (show CD8A Antibodies)- single-positive stage are impaired in Themis-/- mice
The results demonstrate an essential requirement for the PRR (show PVRL1 Antibodies) and NLS (show ALDH1A2 Antibodies) motifs but not the conserved CABIT cysteines for Themis1 function.
THEMIS is required for the development and ultimately the function of proinflammatory T cells.
by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection
Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.
thymocyte selection associated
, thymocyte selection pathway associated
, GRB2-associated protein
, protein THEMIS
, signaling phosphoprotein specific for T cells
, thymocyte expressed molecule involved in selection
, thymocyte-expressed molecule involved in selection
, grb2-associating protein
, protein thylex
, thymus lymphocyte exclusively expressed
, Thymocyte-expressed molecule involved in selection