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The protein encoded by TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Additionally we are shipping Thymopoietin Antibodies (112) and Thymopoietin Proteins (10) and many more products for this protein.
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Study found TMPO is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 (show CASP3 ELISA Kits) and PARP (show COL11A2 ELISA Kits) protein levels.
The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C (show LMNA ELISA Kits), LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle.
The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A (show LMNA ELISA Kits), while its interaction with progerin is significantly reduced.
Results highlight the interactions at the nuclear envelope where mutations in the EMD and TMPO gene in combination with mutations in SUN1 have an impact on several components of the network.
Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.
this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F (show E2F1 ELISA Kits) and p53 (show TP53 ELISA Kits) activities associate with the positive and negative regulation of LAP2alpha expression, respectively
data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C (show LMNA ELISA Kits) complexes
Results indicate that in vitro, the interaction between HA95 (show AKAP8L ELISA Kits) and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 (show AKAP8L ELISA Kits) rather than by CDK1 (show CDK1 ELISA Kits)- or PKC-mediated phosphorylation of LAP2beta
LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
A predicted Arg690Cys substitution within the LAP2 gene is implicated in the pathogenesis of genetic forms of dilated cardiomyopathy.
Lamin (show LMNA ELISA Kits)-associated polypeptide (LAP)2 beta assembles around only alternative oocyte chromatin after complete dephosphorylation of histone H3 (show HIST3H3 ELISA Kits) following fertilization and activation. (lamina-associated polypeptide 2; LAP2beta)
Lifespan and body mass were increased in Lmna (show LMNA ELISA Kits)(-/-)Lap2alpha(-/-) mice compared with Lmna (show LMNA ELISA Kits) deficient mice.
Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C (show LMNA ELISA Kits) is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C (show LMNA ELISA Kits) in the regulation of tissue progenitor cells are not affected in Lmna (show LMNA ELISA Kits)(DeltaK32/DeltaK32) mice.
LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific gene expression during muscle regeneration, muscle remodeling and stress response.
TSLP (show TSLP ELISA Kits) diverts airway tolerance against ovalbumin (show OVA ELISA Kits) (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.
The age-related down-regulation of Wnt4 (and subsequently FoxN1), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.
Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.
Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 (show GATA4 ELISA Kits) and MEF2c (show MEF2C ELISA Kits), while dstrophin deficiency in Mdx (show DMD ELISA Kits) mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.
In agreement with its regulation by E2F (show E2F1 ELISA Kits), LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate
Loss of LAP2-Lmna (show LMNA ELISA Kits) complexes causes erythroid and epidermal progenitor hyperproliferation.
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, lamina-associated polypeptide 2, isoform alpha-like
, TP beta
, Thymopoietin (lamina associated polypeptide 2)
, lamina-associated polypeptide 2
, thymopoietin isoform beta
, LEM domain containing 4
, TP alpha
, TP beta/gamma
, thymopoietin-related peptide isoform alpha
, thymopoietin-related peptide isoforms beta/gamma
, lamina associated polypeptide 2
, lamin-associated polypeptide 2beta
, thymopoietin II
, lamina-associated protein 2