Thyroid Hormone Receptor Interactor 4 Proteins (TRIP4)

Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Additionally we are shipping TRIP4 Antibodies (90) and TRIP4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIP4 9325 Q15650
TRIP4 56404 Q9QXN3
Rat TRIP4 TRIP4 315769  
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Top TRIP4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details

TRIP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Thyroid Hormone Receptor Interactor 4 (TRIP4) Interaction Partners

Human Thyroid Hormone Receptor Interactor 4 (TRIP4) interaction partners

  1. Study showed that TRIP4 promoted melanoma growth through modulation of COX-2 and iNOS expression partially by activating NF-kappaB signaling indirectly and partially by the direct anchoring of itself at COX-2 and iNOS promoter via synergy with p300. Clinical data showed that high expression of TRIP4 was positively correlated with increased expression of COX-2 and iNOS and predicted poor prognosis in melanoma patients.

  2. Reports reveal the first TRIP4 mutation defining a novel form of congenital muscle disease and establish the importance of ASC-1 in human skeletal muscle, identify transcriptional co-regulation as novel pathophysiological pathway, define ASC-1 as a regulator of late myogenic differentiation and suggest defects in myotube growth as a novel myopathic mechanism.

  3. GWAS in a large Spanish sample identifies TRIP4 (rs74615166) as a significant locus for Alzheimer's disease risk.

  4. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.

Mouse (Murine) Thyroid Hormone Receptor Interactor 4 (TRIP4) interaction partners

  1. homozygous and compound-heterozygous nonsense and frameshift TRIP4 and ASCC1 mutations that cosegregated with the Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture phenotype

  2. ASC-1 exists as a steady-state complex associated with three polypeptides, P200, P100, and P50, in HeLa nuclei.

TRIP4 Protein Profile

Protein Summary

Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity).

Gene names and symbols associated with TRIP4

  • thyroid hormone receptor interactor 4 (TRIP4)
  • thyroid hormone receptor interactor 4 (TREPR_2022)
  • thyroid hormone receptor interactor 4 (trip4)
  • thyroid hormone receptor interactor 4 L homeolog (trip4.L)
  • thyroid hormone receptor interactor 4 (Trip4)
  • 4930558E03Rik protein
  • ASC-1 protein
  • Asc1 protein
  • BB191711 protein
  • HsT17391 protein
  • im:7143009 protein
  • si:busm1-221i3.1 protein
  • si:dkey-173l11.4 protein
  • TRIP4 protein
  • zgc:153348 protein

Protein level used designations for TRIP4

thyroid hormone receptor interactor 4 , TR-interacting protein 4 , TRIP-4 , activating signal cointegrator 1 , thyroid receptor interacting protein 4 , thyroid receptor-interacting protein 4 , transcription coactivator Asc1

GENE ID SPECIES
453505 Pan troglodytes
678681 Ovis aries
10681207 Treponema primitia ZAS-2
100053730 Equus caballus
100145534 Xenopus (Silurana) tropicalis
9325 Homo sapiens
568585 Danio rerio
443804 Xenopus laevis
415330 Gallus gallus
478340 Canis lupus familiaris
533430 Bos taurus
56404 Mus musculus
315769 Rattus norvegicus
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