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The protein encoded by THRSP is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.
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The results of the present study indicated that Spot14/S14R (show m1ip1 Proteins) were differently expressed in MSC (show MSC Proteins) adipogenesis in AIS (show AR Proteins) patients, and they may be important in the abnormal adipogenic differentiation in AIS (show AR Proteins).
In (show PSMD8 Proteins)human breast cancer cell lines, S14 expression was highest in those representing the luminal subtype compared to those cell lines with basal characteristics.
Partial silencing of RPS14 (show RPS14 Proteins) inhibits the proliferation of SKM-1, an acute myeloid leukemia (show BCL11A Proteins) cell line, and RPS14 (show RPS14 Proteins) negatively regulates p53 (show TP53 Proteins) activation in SKM-1 cells.
RPS14 (show RPS14 Proteins) stabilized and activated p53 (show TP53 Proteins) by inhibiting HDM2-mediated p53 (show TP53 Proteins) polyubiquitination and degradation
Patients with nonclassical Diamond Blackfan anemia and other hypoproliferative anemias may have somatically acquired 5q deletions with RPS14 (show RPS14 Proteins) haploinsufficiency
Data indicate that RPS14 (show RPS14 Proteins) negates c-Myc (show MYC Proteins) functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA.
lower RPS14 (show RPS14 Proteins) predicts prolonged survival and possible response to lenalidomide in lower risk MDS (show PAFAH1B1 Proteins) patients.
RPS14 (show RPS14 Proteins) and RPS19 (show RPS19 Proteins) have distinct roles in regulating the MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins) feedback loop in response to ribosomal stress
Loss of RPS14 (show RPS14 Proteins) is associated with 5q-syndrome.
Combined loss of miR (show MLXIP Proteins)-145 and RPS14 (show RPS14 Proteins) cooperates to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome.
These findings implicate Spot14 as a direct protein enhancer of FASN (show FASN Proteins) catalysis in the mammary gland during lactation when maximal MCFA production is needed.
S14 has a potential role in regulating mammary tumor growth and fatty acid synthesis in vivo. Modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes.
Data indicate SPOT14 as a potent marker for adult NSPCs that react dynamically to positive and negative neurogenic regulators.
Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor alpha (show NR1H3 Proteins) through a sterol regulatory element-binding protein (show CNBP Proteins) 1c-dependent mechanism in mice.
The structure of S14 suggests a mechanism whereby heterodimer formation with MIG12 attenuates the ability of MIG12 to activate ACC.
Spot 14 protein, absent in the lactating mammary gland, is required for maximum efficiency of de novo lipid synthesis in vivo
the daily rhythm of Spot14 expression in the liver is under the control of the light-entrainable oscillator, food-entrainable oscillator, and food-derived nutrients, in a separate or cooperative manner
the S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse
Weaning-to-oestrus interval (WEI) was associated with five single nucleotide polymorphisms (SNPs). A single THRSP SNP maintained an association with WEI after correction testing.
Data support the putative role of THRSP as transcriptional regulator and demonstrate that an increased expression of THRSP in M. longissimus is a consequence of but not the reason for a higher number of intramuscular adipocytes in cattle with enhanced IMF (show MDFI Proteins) deposition.
THRSP may regulate expression of PPARgamma (show PPARG Proteins) and SREBP1 (show SREBF1 Proteins) and can regulate milk fat synthesis by directly affecting the activity of some classical lipogenic enzymes.
The authors report exonic nucleotide sequence variants in the THRSP gene and evaluate their associations with fatty acid composition in Korean cattle.
Study provides strong support for a central role of sterol response element binding protein 1(SREBP1 (show SREBF1 Proteins)) and S14 in the regulation of milk fat synthesis.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, lipogenic protein 1
, spot 14 protein
, thyroid hormone responsive (SPOT14 homolog, rat)
, thyroid hormone responsive SPOT14
, thyroid hormone-inducible hepatic protein
, 40S ribosomal protein S14
, emetine resistance
, thyroid hormone responsive SPOT14 homolog
, Lipogenic protein S14
, thyroid hormone responsive spot 14 alpha
, thyroid hormone-responsive protein