Thyroid Hormone Responsive Proteins (THRSP)

Human Thyroid Hormone Responsive (THRSP) interaction partners

1. The results of the present study indicated that Spot14/S14R were differently expressed in MSC adipogenesis in AIS patients, and they may be important in the abnormal adipogenic differentiation in AIS.

2. In human breast cancer cell lines, S14 expression was highest in those representing the luminal subtype compared to those cell lines with basal characteristics.

3. N-terminally truncated human Thrsp and its selenomethionyl derivative were collected to 4.0, 3.0 and 3.6 A resolution

4. significantly greater thyroid hormone response for the human promoter, compared with the rat.

5. These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes.

6. human Spot 14 protein might regulate the p53 target gene, p21(WAF1/Cip1), via its direct interaction with the thyroid receptor or other p53 coactivators, such as Zac1.

Mouse (Murine) Thyroid Hormone Responsive (THRSP) interaction partners

1. These findings implicate Spot14 as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.

2. S14 has a potential role in regulating mammary tumor growth and fatty acid synthesis in vivo. Modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes.

3. Data indicate SPOT14 as a potent marker for adult NSPCs that react dynamically to positive and negative neurogenic regulators.

4. Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor alpha through a sterol regulatory element-binding protein 1c-dependent mechanism in mice.

5. The structure of S14 suggests a mechanism whereby heterodimer formation with MIG12 attenuates the ability of MIG12 to activate ACC.

6. Spot 14 protein, absent in the lactating mammary gland, is required for maximum efficiency of de novo lipid synthesis in vivo

7. the daily rhythm of Spot14 expression in the liver is under the control of the light-entrainable oscillator, food-entrainable oscillator, and food-derived nutrients, in a separate or cooperative manner

8. the S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse

Pig (Porcine) Thyroid Hormone Responsive (THRSP) interaction partners

1. Weaning-to-oestrus interval (WEI) was associated with five single nucleotide polymorphisms (SNPs). A single THRSP SNP maintained an association with WEI after correction testing.

Cow (Bovine) Thyroid Hormone Responsive (THRSP) interaction partners

1. Data support the putative role of THRSP as transcriptional regulator and demonstrate that an increased expression of THRSP in M. longissimus is a consequence of but not the reason for a higher number of intramuscular adipocytes in cattle with enhanced IMF deposition.

2. THRSP may regulate expression of PPARgamma and SREBP1 and can regulate milk fat synthesis by directly affecting the activity of some classical lipogenic enzymes.

3. The authors report exonic nucleotide sequence variants in the THRSP gene and evaluate their associations with fatty acid composition in Korean cattle.

4. Study provides strong support for a central role of sterol response element binding protein 1(SREBP1) and S14 in the regulation of milk fat synthesis.