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TFPI2 encodes a member of the Kunitz-type serine proteinase inhibitor family. Additionally we are shipping TFPI2 Antibodies (136) and TFPI2 Kits (50) and many more products for this protein.
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Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin (show PLG Proteins), factor XIa, and kallikrein (show KLK4 Proteins)
estrogen induced TFPI-2 expression in MCF7 cells is mediated by ERalpha (show ESR1 Proteins) and also by the action of LSD1 (show KDM1A Proteins).
TFPI2 hypermethylation is associated with colorectal cancer.
our research indicated that miR (show MLXIP Proteins)-130a functions as an oncogene (show RAB1A Proteins) by targeting TFPI2, miR (show MLXIP Proteins)-130a inhibition reduced the growth and angiogenesis of hemangioma by inactivating the FAK (show PTK2 Proteins)/PI3K (show PIK3CA Proteins)/Rac1/mdm2 (show MDM2 Proteins) pathway
TFPI-2 expression was decreased in bladder cancer. TFPI-2 expression was decreased with progression in tumor grade and stage and was correlated to decreased apoptosis.
TFPI2 is a useful serum biomarker for preoperative clinical diagnosis of CCC.
This TPR-dependent PP5 inhibition shown by Ro 90-7501 is a unique and novel inhibitory mechanism, which might be a useful tool for studies of PP5 on both regulatory mechanism and drug discovery.
Over-expression of TFPI-2 and aberrant promoter methylation status presented in the preeclampsia placentas, suggesting that epigenetic mechanism might contribute to the pathogenesis of preeclampsia.
Data show that silencing tumor-endothelial cells (EC) for trypsinogen 4 (show PRSS3 Proteins) accumulated tissue factor pathway inhibitor-2 (TFPI-2) in the matrix.
Hypermethylation of TFPI2 promoter is increased in inflamed colon tissue.
Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin (show PLG Proteins), factor XIa, and kallikrein (show KLK1 Proteins)
A novel mouse model is presented and can be used to investigate the role of TFPI-2 in the process of atherosclerosis.
Over-expression of TFPI-2 promotes atherosclerotic plaque stability, which may be related to inhibition of matrix metalloproteinases.
Bovine TFPI2 was compared to mouse TFPI2.
human and murine TFPI-2 have different functions in liver regulation during inflammation in the two species
Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis, cardiovascular diseases, chronic inflammation, or diabetes.
Deficiency for the histone methyltransferase EHMT2 (show EHMT2 Proteins) or for the Polycomb group protein EED (show EED Proteins), leads to biallelic expression of Tfpi2 in the extra-embryonic lineages, whereas the other genes in the cluster maintain correct imprinting.
Dynamic changes of Tfpi2 associated with Il-1beta (show IL1B Proteins) and Tnf-alpha (show TNF Proteins) in the development of acute lung injury are reported.
Bovine TFPI2 was cloned and its expression and characterization determined.
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants.
tissue factor pathway inhibitor 2
, tissue factor pathway inhibitor-2
, Tissue factor pathway inhibitor 2
, placental protein 5
, retinal pigment epithelium cell factor 1