anti-Toll Interacting Protein (TOLLIP) Antibodies

TOLLIP encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. Additionally we are shipping TOLLIP Proteins (20) and TOLLIP Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TOLLIP 54472 Q9H0E2
TOLLIP 54473 Q9QZ06
TOLLIP 361677 A2RUW1
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Top anti-TOLLIP Antibodies at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TOLLIP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Hela cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Tollip antibody, Western blotting Lane 1: PANC Cell Lysate Lane 2: HELA Cell Lysate Lane 3: U87 Cell Lysate Anti-Tollip antibody, IHC(P) IHC(P): Human Prostatic Cancer Tissue 100 μg 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Tollip Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Brain 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IP, IHC, WB Immunohistochemical analysis of TOLLIP staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of TOLLIP expression in Jurkat (A), LNCaP (B), HepG2 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts of PC-3, using TOLLIP antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277184 staining  HuvEc cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Mouse Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded human stomach using TOLLIP antibody at dilution of 1:200 (x400 lens) Immunofluorescence analysis of U2OS cell using TOLLIP antibody. Blue: DAPI for nuclear staining. 100 μL 13 to 14 Days
$393.25
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human 293T Cells. 100 μg 13 to 16 Days
$342.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using TOLLIP antibody. 100 μL 11 to 13 Days
$366.77
Details
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details

Top referenced anti-TOLLIP Antibodies

  1. Monoclonal TOLLIP Primary Antibody for ELISA, WB - ABIN533795 : Didierlaurent, Brissoni, Velin, Aebi, Tardivel, Käslin, Sirard, Angelov, Tschopp, Burns: Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. in Molecular and cellular biology 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal TOLLIP Primary Antibody for IHC (fro), WB - ABIN550242 : Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal TOLLIP Primary Antibody for ICC, IF - ABIN4361304 : Toruń, Szymańska, Castanon, Wolińska-Nizioł, Bartosik, Jastrzębski, Miętkowska, González-Gaitán, Miaczynska: Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling. in PLoS ONE 2015 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal TOLLIP Primary Antibody for IP, WB - ABIN4361306 : Neumann, Kollewe, Pich, Cao, Resch, Martin: Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation. in Journal of leukocyte biology 2008 (PubMed)
    Show all 2 Pubmed References

  5. Cow (Bovine) Polyclonal TOLLIP Primary Antibody for WB - ABIN2777431 : Schimming, Parwez, Petrasch-Parwez, Nothnagel, Epplen, Hoffjan: Association of toll-interacting protein gene polymorphisms with atopic dermatitis. in BMC dermatology 2007 (PubMed)

  6. Human Polyclonal TOLLIP Primary Antibody for ICC, ELISA - ABIN1003313 : Janeway, Medzhitov: Innate immune recognition. in Annual review of immunology 2002 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal TOLLIP Primary Antibody for ICC, ELISA - ABIN1003312 : Zhang, Ghosh: Negative regulation of toll-like receptor-mediated signaling by Tollip. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 Pubmed References

  8. Human Polyclonal TOLLIP Primary Antibody for IHC (p), WB - ABIN3042954 : Liu, Wang, Qian, Li: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. in International journal of molecular medicine 2014 (PubMed)

More Antibodies against TOLLIP Interaction Partners

Human Toll Interacting Protein (TOLLIP) interaction partners

  1. Our results indicate that polymorphisms in TOLLIP influence the risk of pulmonary tuberculosis disease.

  2. Data reveal a novel mechanism in Tollip alteration that underlies the inflamed and incompetent polarization of neutrophils leading to severe outcomes of septic colitis.

  3. Our data suggest that Tollip SNP rs5743899 may predict varying airway response to RV infection in asthma.

  4. pharmacogenetic analysis of patients enrolled in an idiopathic pulmonary fibrosis (IPF) clinical trial identified a variant within TOLLIP to be associated with differential response to N-acetylcysteine therapy.

  5. study to examine potential associations between a selection of SNPs in the genes encoding TLR2 and TOLLIP, and predisposition, severity and outcome of Staphylococcus aureus bloodstream infections (SABSI); the TLR2 and TOLLIP polymorphisms were not associated with susceptibility to SABSI, severity, 30-day all-cause mortality, or SABSI caused by the clonal complex 30 genotype

  6. Toll-interacting protein (TOLLIP) is a ubiquitin-binding protein that regulates innate immune responses.

  7. Knock-down of Tollip promotes HIV-1 reactivation from latency.

  8. Toll-interacting protein rs5743867 polymorphism tends to decrease the risk of sepsis in infants undergoing complex open heart surgery.

  9. Variants in the TOLLIP gene are associated with higher circulating PAI-1 plasma levels and association with clinical Primary Graft Dysfunction Risk.

  10. Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism.

  11. These data suggest that M. leprae upregulates IL-1Ra by a TOLLIP-dependent mechanism; inhibition of TOLLIP may decrease an individual's susceptibility to leprosy and offer a novel therapeutic target for IL-1-dependent diseases.

  12. Observed expression patterns of several TLR inhibitory proteins with a noticeable suppression in expression of two of these; PPARgamma and TOLLIP in both ulcerative colitis and Crohn's disease and in both active and inactive disease states.

  13. Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling.

  14. The two polymorphisms, rs5743899 and rs3750920, in the TOLLIP gene are independently associated with an increased risk of developing cutaneous leishmaniasis (CL).

  15. TOLLIP encodes toll-interacting protein (TOLLIP), which is an inhibitory adaptor protein acting downstream from the toll-like receptors (TLRs). Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA

  16. we identify a novel function of Tollip in regulating the canonical Wnt pathway which is evolutionarily conserved between fish and humans. Tollip-mediated inhibition of Wnt signaling may contribute to embryonic development and to carcinogenesis.

  17. TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis

  18. Study shows that host factor Tollip inhibits HIV LTR-driven gene expression by suppressing NF-kappaB activation revealing its novel role in modulating HIV-1 infection.

  19. Which is achieved by elevated level of toll-interacting protein (TOLLIP) in presence of porin.

  20. The MUC5B promoter polynmorphism, TOLLIP, is a strong risk factor for idiopathic pulmonary fibrosis in a Mexican population but is very rare in a Korean population.

Mouse (Murine) Toll Interacting Protein (TOLLIP) interaction partners

  1. L. donovani exploited the multitasking function of Tollip for its own establishment through downregulating IL-1R1/TLR signaling in macrophages.

  2. Tollip differentially modulates HIF1alpha and STAT5 expression in fibroblasts.

  3. Tollip-deficiency may accelerate neuron death related to neurological disease such as Alzheimer's disease

  4. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression

  5. Tollip deficiency selectively leads to enlarged yet stable atherosclerotic plaques, increased circulating lipids, liver steatosis, and reduced inflammation. Compromised lipophagy and reduced expression of inflammatory mediators due to Tollip deficiency may be the underlying causes.

  6. This study demonstrated that a critical role of Tollip in the early phase of TLR4-mediated neuroinflammation.

  7. Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling.

  8. TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis

  9. Data show that histone lysine methyltransferase Ezh1 promotes toll-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity.

  10. Overall, our data show an essential role for Tollip on colitis susceptibility in mice.

  11. negative regulator of pathological cardiac hypertrophy by blocking the AKT signalling pathway

  12. Tollip cooperates with Smad7 to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI, whereby negatively regulates TGF-beta signaling pathway.

  13. DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1- and Tollip-mediated negative signaling.

  14. Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 receptor-associated kinase (IRAK)-1 to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 in chronic low-grade inflammatory disease.

  15. Tollip is a critical mediator responsible for the anti-inflammatory action of epigallocatechin-3-gallate in activated macrophages.

  16. a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin

  17. These results indicate that, in conjunction with Tollip, Tom1 family proteins play an important role in recruiting clathrin onto endosomes and suggest that they modulate endosomal functions.

  18. Tollip controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS.

Atlantic Salmon (Salmo salar) Toll Interacting Protein (TOLLIP) interaction partners

  1. identified two closely related Tollip-encoding genes in Atlantic salmon (Salmo salar)

Rainbow Trout (Oncorhynchus mykiss) Toll Interacting Protein (TOLLIP) interaction partners

  1. Both Tollip-encoding genes are ubiquitously and equally expressed, as indicated by similar mRNA concentrations of both factors in any one tissue, and Tollip expression was found to be up-regulated by viral infection

TOLLIP Antigen Profile

Protein Summary

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.

Gene names and symbols associated with TOLLIP

  • toll interacting protein (TOLLIP) antibody
  • toll interacting protein (Tollip) antibody
  • toll interacting protein (tollip) antibody
  • toll-interacting protein (LOC552034) antibody
  • toll-interacting protein-like (LOC100169858) antibody
  • toll-interacting protein (Tollip) antibody
  • toll interacting protein L homeolog (tollip.L) antibody
  • toll interacting protein S homeolog (tollip.S) antibody
  • Toll-interleukine I receptor interacting protein I (LOC100136122) antibody
  • 4930403G24Rik antibody
  • 4931428G15Rik antibody
  • fk22a02 antibody
  • GB17961 antibody
  • IL-1RAcPIP antibody
  • im:7145391 antibody
  • TOLIP antibody
  • tollip antibody
  • tollip1 antibody
  • tollipa antibody
  • wu:fk22a02 antibody
  • zgc:76985 antibody

Protein level used designations for TOLLIP

adapter protein , toll-interacting protein , toll interacting protein , Toll-interleukin 1 receptor interacting protein , toll-interacting protein B , toll-interacting protein A , Toll-interacting protein 1 , tollip I

GENE ID SPECIES
54472 Homo sapiens
54473 Mus musculus
336876 Danio rerio
361677 Rattus norvegicus
423099 Gallus gallus
448770 Xenopus (Silurana) tropicalis
483657 Canis lupus familiaris
539480 Bos taurus
552034 Apis mellifera
702587 Macaca mulatta
450943 Pan troglodytes
100169858 Salmo salar
100616078 Amphimedon queenslandica
443846 Xenopus laevis
734800 Xenopus laevis
100136122 Oncorhynchus mykiss
100730994 Cavia porcellus
105027394 Esox lucius
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