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Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis.
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These results demonstrate that the nucleocytoplasmic distribution of TALDO1, modulated via alternative translational initiation and dimer formation, plays an important role in a wide range of metabolic networks
The above findings support the premise that biallelic mutations in TALDO1 are responsible for transaldolase deficiency and confirm the broad phenotypic variability of this condition, even with the same genotype.
This study expands the clinical definition of transaldolase deficiency, and adds to its allelic heterogeneity.
Data suggest that exchange reactions during gluconeogenesis catalyzed by transaldolase and triose-phosphate isomerase (show TPI1 Antibodies) do not differ between subjects with type 2 diabetes and control subjects under fasting or hyperglycemic conditions.
renal phenotype of patients with transaldolase deficiency
these data provide strong experimental evidence that transaldolase exchange occurs in humans, resulting in an overestimate of gluconeogenesis
granzyme B-cleaved transaldolase-specific T cell-mediated cytotoxicity may contribute to the progressive destruction of oligodendrocytes in patients with multiple sclerosis
transaldolase is regulated by ZNF143 (show ZNF143 Antibodies) in a tissue-specific manner
Mutation in the TALDO1 gene was found in patients with hydrops fetalis and neonatal multi-organ disease.
Transaldolase-deficient patients had significantly increased urinary heptoses, revealing novel urinary biomarkers for identification of the deficiency.
These data reveal an essential role of transaldolase in sperm-cell mitochondrial function and, thus, male fertility.
Reduced beta-catenin (show CTNNB1 Antibodies) phosphorylation and enhanced c-Jun (show JUN Antibodies) expression in Taldo1-/- livers reflected adaptation to oxidative stress
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
, glycerone transferase
, EPS8-like 2
, transaldolase 1
, Transaldolase 1