anti-Transcription Factor 12 (TCF12) Antibodies

The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Additionally we are shipping TCF12 Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TCF12 6938 Q99081
TCF12 21406 Q61286
TCF12 25720 P51514
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-TCF12 Antibodies at antibodies-online.com

Showing 10 out of 81 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TCF12 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate TCF12 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-TCF12  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Jurkat cell lysate  TCF12 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: TCF4 Sample Tissue: Human Uterus Tumor Antibody Dilution: 1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TCF12 Antibody Titration:  0.06ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Lung Host:  Rabbit  Target Name:  TCF12  Sample Type:  Human Fetal Brain  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TCF12 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated EIA, WB TCF12 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TCF12 antibody detected the TCF12 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-TCF12 / HEB antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this pro ... 100 μL Log in to see 11 to 14 Days
$727.83
Details
Human Mouse Un-conjugated IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to TCF12 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1 ug/ml] TCF12 monoclonal antibody (M01), clone 2E9 Western Blot analysis of TCF12 expression in Jurkat . 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-TCF12 Antibodies

  1. Cow (Bovine) Polyclonal TCF12 Primary Antibody for WB - ABIN2780487 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal TCF12 Primary Antibody for IF (p), IHC (p) - ABIN1385824 : Li, Leng, Liu, Hu, Zhang, Li, Jiang, Zhou, Xu: Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma. in Tumour biology 2017 (PubMed)

More Antibodies against TCF12 Interaction Partners

Human Transcription Factor 12 (TCF12) interaction partners

  1. directly interacts with AML1-ETO, confers new DNA-binding capacity to the AML1-ETO-containing transcription factor complex, and is essential for leukemogenesis

  2. Pathogenic or likely pathogenic variants in non-FGFR genes were identified in 43 individuals, with diagnostic yields of 14% and 15% in retrospective and prospective cohorts, respectively. Variants were identified most frequently in TCF12 (N = 22) and EFNB1 (N = 8), typically in individuals with nonsyndromic coronal craniosynostosis or TWIST1-negative clinically suspected Saethre-Chotzen syndrome.

  3. These results identify HEB as a critical regulator of human mesodermal and hematopoietic specification.

  4. HDAC1 promoted migration and invasion of gallbladder tumor cells by binding with TCF12 to promote epithelial mesenchymal transformation.

  5. Study describes the identification of three large inherited intragenic exon deletions in TCF12 using whole-genome sequencing and one large inherited duplication using targeted TCF12 sequencing in patients with craniosynostosis.

  6. Heb expression is regulated by Med19 in breast cancer cells.

  7. enforced expression of transcription factor 12 suppressed cell proliferation, migration, and invasion in vitro and inhibited tumor growth in vivo. In conclusion, transcription factor 12 protein may be a novel molecule which plays a critical role in prostate cancer progression and patients' prognosis, suggesting it might be a promising therapeutic target for prostate cancer therapy

  8. HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells.

  9. Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12 in myeloid leukemia.

  10. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.

  11. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type

  12. several familial cases of coronal synostosis associated with mutations in TCF12

  13. In t(8;21) leukemia cells, the two E proteins, HEB and E2A, function as components of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.

  14. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.

  15. the CD91/IKK/NF-kappaB signaling cascade is involved in secreted HSP90alpha-induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion

  16. TCF12 functioned as a transcriptional repressor of E-cadherin and its overexpression was significantly correlated with the occurrence of CRC metastasis.

  17. HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1

  18. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

  19. T cell development is impaired by Id2, most likely by sequestering HEB, whereas NK cell development is promoted by increasing a pool of CD1a-CD5+ NK cell progenitors, which together with IL-15 differentiate into mature NK cells

Mouse (Murine) Transcription Factor 12 (TCF12) interaction partners

  1. TCF-1 both enhances HEB protein stability and functionally cooperates with HEB in defining the epigenetic and transcriptional status of CD4(+)CD8(+) thymocytes

  2. HEB may be required for a proper regulation of Lpar1 expression in the embryonic neocortical neuroblast cells.

  3. Mouse genetics further reveal requirements for Twist1 and Tcf12 in both the frontal and parietal bones for suture patency, and to maintain putative progenitors in the coronal region

  4. Study results place HEB at the top of the known gene network that regulates gammadeltaT17 cell programming.

  5. Tcf12 is a transcription factor highly expressed in the nuclei of stem cells and its downregulation plays an essential role in osteoblast differentiation.

  6. we identified transcription factor TCF12 as a new target of miR-211 in oral squamous cell carcinoma

  7. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  8. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1 in the normal development of the coronal sutures

  9. Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

  10. Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development.

  11. the earliest event in B-cell specification involves the induction of FOXO1 expression and requires the combined activities of E2A and HEB

  12. These results showed a new set of interactions between HEB, Notch1, and GATA3 that regulate the T-cell fate choice in developing thymocytes.

  13. HEBAlt enforces T-lineage cell development during hematopoiesis.One role of HEBAlt may be to suppress myeloid development in developing T-cell precursors.

  14. Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.

  15. HEBAlt can suppress B cell or myeloid potential in a context-specific manner, which suggests a role for this factor in maintaining T lineage priming prior to commitment.

  16. HEB is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.

  17. the dosage of HEB determines pT alpha gene expression in immature T cells

  18. the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells

  19. repression of E47/HEB by tal1/scl induces leukemia

  20. dHAND/E-protein (E2A, ME2, and ALF1) heterodimers have distinct DNA binding specificities

Zebrafish Transcription Factor 12 (TCF12) interaction partners

  1. we show that combinatorial loss of TCF12 and TWIST1 homologs in zebrafish also results in specific loss of the coronal suture

TCF12 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with TCF12

  • transcription factor 12 (TCF12) antibody
  • transcription factor 12 (tcf12) antibody
  • transcription factor 12 (Tcf12) antibody
  • transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) L homeolog (tcf12.L) antibody
  • A130037E08Rik antibody
  • ALF1 antibody
  • bHLHb20 antibody
  • CRS3 antibody
  • HEB antibody
  • HEBAlt antibody
  • HsT17266 antibody
  • HTF-4 antibody
  • HTF4 antibody
  • ME1 antibody
  • REB antibody
  • SCBPA antibody
  • TCF12 antibody
  • wu:fb74g05 antibody
  • wu:fc43e06 antibody
  • zgc:85956 antibody
  • zgc:110341 antibody

Protein level used designations for TCF12

transcription factor 12 , transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) , DNA-binding protein HTF4 , E-box-binding protein , TCF-12 , class B basic helix-loop-helix protein 20 , helix-loop-helix transcription factor 4 , transcription factor HTF-4 , class A helix-loop-helix transcription factor ME1 , SCBP alpha , SCBP-alpha , salivary-specific cAMP response element-binding protein alpha , TF12 , basic helix-loop-helix protein , class A helix-loop-helix transcription factor GE1 , XE1.1

GENE ID SPECIES
453466 Pan troglodytes
100339415 Oryctolagus cuniculus
100460448 Pongo abelii
100553875 Anolis carolinensis
100603993 Nomascus leucogenys
6938 Homo sapiens
509039 Bos taurus
21406 Mus musculus
25720 Rattus norvegicus
407985 Danio rerio
396334 Gallus gallus
100684199 Canis lupus familiaris
399451 Xenopus laevis
Selected quality suppliers for anti-TCF12 (TCF12) Antibodies
Did you look for something else?