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S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop.
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These data demonstrate the essential role of TFB2M in mtDNA transcription, and reveal the complex cellular, biochemical, and molecular responses induced by impairment of oxidative phosphorylation during Drosophila development.
Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation.
demonstrate that a complex composed of TFAM (show TFAM ELISA Kits) and POLRMT was readily formed at the promoter but alone was insufficient for promoter melting, which only occurred when TFB2M joined the complex
The results reveal the organization of TFAM (show TFAM ELISA Kits), POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.
only two essential initiation factors, TFAM (show TFAM ELISA Kits) and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome
The mRNA levels of TFB1M (show TFB1M ELISA Kits) and TFB2M are influenced by endurance training
Distinct, but possibly coordinated functions of mtTFB1 (show TFB1M ELISA Kits) and mtTFB2 in mitochondrial gene expression and biogenesis.
This study suggested that DNA variants in TFB2M did not contribute to the risk for parkinson disease.
determined the variation in the TFAM (show TFAM ELISA Kits), TFB1M (show TFB1M ELISA Kits), and TFB2M genes in cardiac hypertrophy
rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M (show TFB1M ELISA Kits), but not TFB2M.
Promoter-independent DNA conformation-dependent transcription required TFB2M.
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
, transcription factor B2, mitochondrial
, dimethyladenosine transferase 2, mitochondrial
, HCV NS5A-transactivated protein 5
, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
, hepatitis C virus NS5A-transactivated protein 5
, mitochondrial 12S rRNA dimethylase 2
, mitochondrial transcription factor B2
, house-keeping protein 1