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Study show that CRTR-1 is generally an activator of transcription (show STAT1 Proteins) and that it modulates the activity of other family members, CP2 (show CP Proteins), NF2d9 (show UBP1 Proteins) and altNF2d9, in a cell specific manner.
LBP-1b (show UBP1 Proteins) is an important SF1 (show NR5A1 Proteins)-independent transcriptional activator stimulating P450scc (show CYP11A1 Proteins) expression in human placental JEG-3 cells, whereas LBP-9 modulates the action of LBP-1b (show UBP1 Proteins), exerting both positive and negative effects
LBP-1b (show UBP1 Proteins) and LBP-9 both stimulate LBP-32/MGR (show GRHL1 Proteins) promoter activity.
Thus, Tfcp2l1 is a critical regulator of intercalated cell-principal cell patterning in kidney collecting ducts, acting cell-autonomously in intercalated cells, and non-cell-autonomously in principal cells.
TFCP2L1 depends on its N-terminus and CP2-like domain to maintain the undifferentiated state of mouse embryonic stem cells.
we found that TFCP2L1 is hexamerized in solution via the C-terminal SAM (show TTN Proteins)-like domain. We also found that homo-oligomerization of SAM (show TTN Proteins)-like domain is dependent on the concentration of the proteins.
study therefore establishes the pivotal role of Klf2 (show KLF2 Proteins) and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Tfcp2l1 is the principal bridge between LIF (show LIF Proteins)/Stat3 (show STAT3 Proteins) input and the transcription factor core of naive pluripotency.
Tfcp2l1 is at the intersection of LIF (show LIF Proteins)- and 2i-mediated self-renewal pathways and plays a critical role in maintaining embryonic stem cell identity.
Cp2l1 expression is required for normal duct development in both the salivary gland and kidney.
Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney.
CP2-related transcriptional repressor 1
, transcription factor CP2-like protein 1
, transcription factor LBP-9
, transcription factor CP2-like 1
, Tcfcp2-related transcriptional repressor 1
, transcription repressor CRTR-1
, transcription factor CP2-like protein 1-like
, LBP protein; likely ortholog of mouse CRTR-1
, transcription factor CP2-like 1 a