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TRRAP encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family.
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Human Monoclonal TRRAP Primary Antibody for ChIP, IP - ABIN2668655
Szutorisz, Canzonetta, Georgiou, Chow, Tora, Dillon: Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. in Molecular and cellular biology 2005
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Data suggest that ubiquitin thioesterase 7 (HAUSP (show USP7 Antibodies)) may act as an oncogenic protein that can modulate c-MYC (show MYC Antibodies) protein expression via transformation-transcription domain-associated protein (TRRAP).
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (show CREBBP Antibodies), CBFA2T3 (show CBFA2T3 Antibodies), AMOTL1 (show AMOTL1 Antibodies), FAT4 (show FAT4 Antibodies), FBXO11 (show FBXO11 Antibodies), PLA2G4D (show PLA2G4D Antibodies), TRRAP and USH2A (show USH2A Antibodies).
MYC associates with STAGA through extended interactions of the TAD with both TRRAP and GCN5.
Findings establish Trrap as a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs (show NR2E3 Antibodies).
TRRAP is targeted for destruction in a cell cycle-dependent fashion.
The over-expression of TRA1 (show HSP90B1 Antibodies) in hepatocirrhosis and hepatocellular carcinoma is correlated with the formation and development of HCC (show FAM126A Antibodies).
TRRAP harbors a recurrent mutation that clustered in one position (p. Ser722Phe) in 6 out of 167 melanoma samples (approx. 4%). The nature, pattern and functional evaluation of the TRRAP recurrent mutation suggest that TRRAP functions as an oncogene (show RAB1A Antibodies).
knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured brain tumor-initiating cells, sensitized the cells to apoptotic stimuli, and negatively affected cell cycle progression.
TRRAP binding and the recruitment of histone H3 (show HIST3H3 Antibodies) and H4 acetyltransferase activities are required for the transactivation of a silent TERT (show TERT Antibodies) gene in exponentially growing human fibroblasts by c-Myc (show MYC Antibodies) or N-Myc protein (show MYCN Antibodies).
Data suggest a model in which p53 (show TP53 Antibodies) directly recruits a TRRAP/acetyltransferase complex to the mdm2 (show MDM2 Antibodies) gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor (show TP53 Antibodies) to regulate gene expression.
TRRAP deficiency impairs B-cell development but does not directly affect class switch recombination (CSR (show SCARA3 Antibodies). Instead, cells induced to proliferate undergo apoptosis. Our findings demonstrate a central and general role of TRRAP in cell proliferation.
expression profiles of Trrap-responsive genes, using cDNA microarray in mitotic cells
Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (show BUB3 Antibodies) proteins Mad1 (show MXD1 Antibodies) and Mad2 (show MXI1 Antibodies).
HAT (show HAT Antibodies) cofactor Trrap and Tip60 (show KAT5 Antibodies) HAT (show HAT Antibodies) bind to the chromatin surrounding sites of DNA double-strand breaks (DSBs). Cells may use the same basic mechanism involving HAT (show HAT Antibodies) complexes to regulate distinct cellular processes, such as transcription and DNA repair.
Fe65 (show APBB1 Antibodies) and its interaction with APP (show APP Antibodies) play an important role in the response to DNA damage by assisting the recruitment
this study has identified a critical role for Trrap in the mechanism that maintains hematopoietic stem cells and hematopoietic system, and underscores the importance of Trrap and histone modifications in tissue homeostasis.
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
350/400 kDa PCAF-associated factor
, tra1 homolog
, transformation/transcription domain-associated protein
, transactivation/transformation-domain associated protein
, transformation/transcription domain-associated protein-like