Transforming Growth Factor, beta Receptor III Proteins (TGFBR3)

This locus encodes the transforming growth factor (TGF)-beta type III receptor. Additionally we are shipping TGFBR3 Antibodies (141) and TGFBR3 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGFBR3 7049 Q03167
TGFBR3 21814 O88393
TGFBR3 29610 P26342
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Top TGFBR3 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 60 to 65 Days
$10,699.55
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
$7,506.65
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg 15 to 18 Days
$688.00
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg 15 to 18 Days
$720.00
Details
Human Cells Mouse His tag 100 μg 14 to 16 Days
$440.65
Details
Baculovirus infected Insect Cells Human His tag 100 μg 14 to 16 Days
$440.65
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$4,244.17
Details

TGFBR3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) , ,
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Rat (Rattus) ,
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More Proteins for Transforming Growth Factor, beta Receptor III (TGFBR3) Interaction Partners

Cow (Bovine) Transforming Growth Factor, beta Receptor III (TGFBR3) interaction partners

  1. Inhibition of genes for betaglycan and FIBP in granulosa cells in vitro suggests that they inhibit estradiol production in regressing subordinate follicles.

Human Transforming Growth Factor, beta Receptor III (TGFBR3) interaction partners

  1. A dormancy mechanism by which DTCs are induced into a dormant state through TGFbetaRIII-p38MAPK-pS249/pT252-RB signaling.

  2. Low TGFBR3 expression is associated with progression of lung cancer.

  3. also observed that the promotion of epithelial-to-mesenchymal transition by miR-19a and miR-424 was mediated by the inhibition of TGFBR3

  4. Loss of TGFBR3 endows clear cell renal cell carcinoma cells with multiple metastatic abilities through TGF-beta-dependent and independent pathways.

  5. We suggest that TGFBR3 protein expression is involved in up-regulated TGF-beta signaling in Marfan syndrome patients with a dominant negative FBN1 gene mutation.

  6. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells

  7. TGF-beta type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin was increased in both subtypes.

  8. TGFBR3 and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas.

  9. opposing functions for the different GAG modifications on TbetaRIII suggesting that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signaling, likely via Wnt sequestration, whereas the chondroitin sulfate GAG chains on TbetaRIII promote Wnt3a signaling.

  10. Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization.

  11. Results show decreased TbetaRIII expression with hepatocellullar carcinoma (HCC) progression leading to the activation of Smad2 and suggest that TbetaRIII acts as a suppressive factor in regulating the migration and invasion of HCC, by inhibiting Smad2 and Akt pathways.

  12. Study shows that TbetaRIII expression is significantly decreased in salivary glands adenoid cystic carcinoma (ACC) patients and defines TbetaRIII as a biomarker exerting antitumor action on ACC progression.

  13. No correlation of loss of heterozygosity at the TGFBR3 locus with clinicopathological parameters suggests that allelic imbalance may be an early genetic event during neoplastic transformation of human endometrium.

  14. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition.

  15. Data suggest a high potential of plasma sTBFbetarIII as a novel diagnostic and prognostic biomarker in breast cancer.

  16. rs1192415 of TGFBR3 is associated with primary open angle glaucoma.

  17. results suggest overexpression of TbetaRIII receptor restored TGF-beta1 sensitivity in CAL-27 cells

  18. The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.

  19. Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta responsiveness and abrogated TbetaRIII's ability to inhibit breast cancer cell migration and invasion.

  20. RS1805110 is not associated with Behcet's disease or idiopathic intermediate uveitis in Caucasian patients.

Mouse (Murine) Transforming Growth Factor, beta Receptor III (TGFBR3) interaction partners

  1. TGFBR3 (betaglycan) functions as an inhibin A, but not an inhibin B, coreceptor in gonadotrope cells in vivo. Mechanisms of inhibin B action merit further investigation.

  2. TGFbetaR3 promotes apoptosis of cardiomyocytes via a p38 pathway-associated mechanism, and loss of TGFbetaR3 reduces myocardial infarction injury.

  3. BMP2 also requires Src for filamentous actin polymerization in Tgfbr3(-/-) epicardial cells.

  4. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells

  5. Study identified a novel major binding site for TGF-beta-like growth factors in TGFR-3. Findings potentially provide novel experimental insight into the general function of zona pellucida domain-containing proteins.

  6. a signaling pathway important in epicardial cell behavior downstream of TGFbetaR3

  7. Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production.

  8. Pro-fibrotic cardiac effect of miR-328 was mediated by down-regulating TGFbR3 and up-regulating TGFb1.

  9. These data reveal a critical, previously unrecognized role for TGFbetaR3 in vascular and osteoblast development during palatogenesis.

  10. These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells.

  11. Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.

  12. work reveals a 'seed and soil' mechanism where TGF-beta2 and TGF-beta-RIII signalling through p38alpha/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis

  13. TGFBR3 mediated suppression of cancer progression includes effects on the tumor immune microenvironment.

  14. Loss of Tgfbr3 compromises the functions of TGFbeta2 in the differentiating fetal testis.

  15. A novel reciprocal loop between miR-21 and TGFbetaRIII in cardiac fibrosis caused by myocardial infarction in mice.

  16. These data suggest that Inhibins and TbetaRIII may function as a molecular pair regulating T cell development.

  17. the relative roles of TGFbetaR3-dependent and -independent signaling in the actions of BMP2 on epicardial cell behavior and demonstrate the critical role of TGFbetaR3 in mediating BMP2-stimulated invasion.

  18. used intact embryos and epicardial cells from E11.5 mouse embryos to reveal the mechanisms by which TGFbetaR3 signals and regulates epicardial cell behavior

  19. TGFBR3 can prevent hypoxia-induced injury in neonatal mice cardiac fibroblasts by negative regulation of TGF-beta signaling.

  20. Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch.

Pig (Porcine) Transforming Growth Factor, beta Receptor III (TGFBR3) interaction partners

  1. This study provides evidence that the expressions of inhibin alpha subunit and betaglycan are inferior in cystic follicles, and this may be caused by the decrease in FSH in the presence of a cystic follicle.

TGFBR3 Protein Profile

Protein Summary

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with TGFBR3

  • transforming growth factor beta receptor 3 (TGFBR3)
  • transforming growth factor beta receptor 3 (tgfbr3)
  • transforming growth factor, beta receptor III (Tgfbr3)
  • transforming growth factor beta receptor 3 (Tgfbr3)
  • 1110036H20Rik protein
  • AU015626 protein
  • AW215636 protein
  • betaglycan protein
  • BGCAN protein
  • DKFZp469I0915 protein
  • TBRIII protein
  • TGFBR3 protein

Protein level used designations for TGFBR3

transforming growth factor, beta receptor III , transforming growth factor, beta receptor III (betaglycan, 300kDa) , betaglycan , transforming growth factor beta receptor type 3-like , TGF-beta receptor type 3 , TGF-beta receptor type III , TGFR-3 , betaglycan proteoglycan , transforming growth factor beta receptor type 3 , transforming growth factor, beta receptor 3 , TGF-beta type III receptor , transforming growth factor beta receptor III , transforming growth factor-beta type III receptor

GENE ID SPECIES
457016 Pan troglodytes
490163 Canis lupus familiaris
705053 Macaca mulatta
784894 Bos taurus
100026705 Monodelphis domestica
100294542 Pongo abelii
100402732 Callithrix jacchus
100483625 Ailuropoda melanoleuca
100552985 Anolis carolinensis
100585692 Nomascus leucogenys
7049 Homo sapiens
374251 Gallus gallus
21814 Mus musculus
29610 Rattus norvegicus
397512 Sus scrofa
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