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The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle.
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Rat (Rattus) Transgelin ELISA Kit for Sandwich ELISA - ABIN433111
Gu, Huang, Shan, Yin, Zheng, Wu: Effects of long-term ketamine administration on rat bladder protein levels: a proteomic investigation using two-dimensional difference gel electrophoresis system. in International journal of urology : official journal of the Japanese Urological Association 2013
High expression level of TAGLN is associated with prostate cancer.
this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer
During transition from the pluripotent stage towards the neural developmental stage, TAGLN is differentially expressed in bipolar patient derived cells compared to control derived cells.
Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.
transgelin (TAGLN), a transforming growth factor beta (TGFbeta (show TGFB1 ELISA Kits))-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells
regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 (show IL8 ELISA Kits) uptake
Serum concentrations of CK-18 (show KRT18 ELISA Kits) fragments and transgelin-2 (show TAGLN2 ELISA Kits) correlate with the severity of NAFLD (show TSC2 ELISA Kits), but not with obesity.
Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis
activated AKT (show AKT1 ELISA Kits) and JNK (show MAPK8 ELISA Kits) signaling pathways promote the overexpression of transgelin
Cofilin-1 (show CFL1 ELISA Kits) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma
CKII (show CSNK2A1 ELISA Kits)-SIRT1 (show SIRT1 ELISA Kits)-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells.
findings reveal for the first time that SM22 is expressed in the nucleus in addition to the cytoplasm of VSMCs to regulate the transcription of Nik and its downstream proinflammatory NF-kB signal pathways as a modulator of SRF during vascular inflammation
The disruption of SM22alpha enhances PDGF-BB-induced GLUT4 translocation and glucose uptake by promoting actin dynamics and cortical actin polymeriza- tion.
Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.
SM22alpha is a phosphorylation-regulated (show PHAX ELISA Kits) suppressor of IKK (show CHUK ELISA Kits)-IkappaBalpha (show NFKBIA ELISA Kits)-NF-kappaB (show NFKB1 ELISA Kits) signaling cascades.
SM22alpha promotes ubiquitination and degradation of MKP3 (show DUSP6 ELISA Kits). SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 (show MAPK1/3 ELISA Kits) signaling.
TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.
SM22alpha-regulated molecular pathways contribute to vascular pathology.
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
, putative transgelin
, 22 kDa actin-binding protein
, smooth muscle protein 22-alpha
, transgelin variant 2
, actin-associated protein p27
, smooth muscle 22 protein
, 25 kDa F-actin-binding protein