anti-Transglutaminase 1, Keratinocyte (TGM1) Antibodies

The protein encoded by TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. Additionally we are shipping TGM1 Kits (26) and TGM1 Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TGM1 60335 P23606
TGM1 7051 P22735
TGM1 21816 Q9JLF6
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Top anti-TGM1 Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TGM1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Transfected 293T 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Transglutaminase 1/TGM1 Antibody  - Analysis in human cell line BEWO. Immunohistochemistry-Paraffin: Transglutaminase 1/TGM1 Antibody  - Staining in human esophagus and colon tissues using anti-TGM1 antibody. Corresponding TGM1 RNA-seq data are presented for the same tissues. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ICC, IHC, IHC (p), IP, WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-TGM1 / Transglutaminase antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Anti-TGM1 antibody, Western blotting Lane 1: Rat Spleen Tissue Lysate Lane 2: Rat Liver Tissue Lysate Lane 3: HELA Cell Lysate Lane 4: COLO320 Cell Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Rabbit Guinea Pig Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$332.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Kidney Tissue; Lane2: Mouse Spleen Tissue; Lane3: Mouse Placenta Tissue. 100 μg Log in to see 13 to 16 Days
$342.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg Log in to see 13 to 16 Days
$362.00
Details
Dog Rabbit Un-conjugated ICC, IHC, WB 100 μg Log in to see 13 to 16 Days
$380.00
Details

More Antibodies against TGM1 Interaction Partners

Cow (Bovine) Transglutaminase 1, Keratinocyte (TGM1) interaction partners

  1. Linkage analysis excluded TGM1 as the cause for ichthyosis phenotype.

Human Transglutaminase 1, Keratinocyte (TGM1) interaction partners

  1. aberrant TGase 1 and TGase 3 localization and distribution are closely related to hyper-keratinization in Oral lichen planus.

  2. p.Ile140Met, p.Pro184Ser, p.Gly357Asp mutations pathogenic

  3. We also reveal that TGM1 modulates lung epithelial junction protein expression, suggesting a potentially protective role for hypoxia-induced TGM1 in pulmonary disease.

  4. A novel TGM1 variant c.1085T>G was found in an Emirati family. The mutation causes a nonsynonymous protein change (p.Leu362Arg) that affects a highly conserved residue in the catalytic core domain of the calcium-dependent transglutaminase-1.

  5. that the up-regulation of molecular signatures for antimicrobial and innate defense responses is characteristic of skin with a transglutaminase 1 deficiency.

  6. Seven of 10 probands with a compound heterozygous TGM1 genotype had a mutation at either arginine 307 or 315, providing evidence that mutations at these sites are temperature sensitive and highlighting the importance of these residues in the pathogenesis of bathing suit ichthyosis

  7. The results strongly supported the participation of TGM1 in the regulation of gastric cancer development. The authors found evidence that the mechanism of action of TGM1 in regulating gastric cancer cell might involve the Wnt signaling pathway, as loss of TGM1 expression in gastric cancer cells led to a significant suppression of Wnt signaling activities.

  8. we identified three novel mutations and one reported mutation in the TGM1 and ABCA12 genes, respectively, in affected siblings of five Saudi unrelated families.

  9. As a further application of the substrate peptide, several substrate candidates of TG1 that may be essential for cornified envelope formation were identified and characterized.

  10. Data indicate a decrease in transglutaminases TG1 and TG3 transcripts by about 70% in foreskins from patients with balanitis xerotica obliterans (BXO) BXO in comparison with patients without BXO and an increase in transglutaminase TG2 mRNA levels by 2.9 fold.

  11. In summary, we have identified three novel sequence variants, one in TGM1 and two in ALOXE3, in three consanguineous families segregating lamellar ichthyosis and congenital ichthyosiform erythroderma types of autosomal recessive congenital ichthyosis.

  12. Our results thus indicated that the TGM1 mutation affects the formation of corni fi ed cell envelope by multiple mechanisms and leads to an almost identical clinical phenotype of generalized erythema and scales.

  13. Two siblings with autosomal recessive congenital ichthyosis, were found to carry a novel aetiological TGM1 mutation that leads to the synthesis of multiple abnormal transcripts.

  14. mRNA expression of transglutaminase 1 and transglutaminase 3 was significantly decreased in patients with chronic periodontitis compared with a healthy control group.

  15. In this study, we found that 14 different TGM1 mutations have been identified and reported in 13 individuals with ARCI from 8 families with congental ichthyosis, comprising 9 missense mutations, 1 deletion and 1 splice-site mutation .

  16. Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis.

  17. IgA-anti-TG1 antibodies were found in 2% and IgA-anti-TG3 antibodies in 3% of patients with active atopic dermatitis (AD). Two out of the 5 patients with AD and concomitant celiac disease had IgA-anti-TG1 and IgA-anti-TG2 antibodies.

  18. All mutations, except a novel deletion of a single nucleotide in exon 13 (c.2149delC), have been reported previously in lamellar ichthyosis.

  19. Most of the mutations we identified in 20 israeli families with autosomal recessive congenital ichthyosis were located within the coding sequence of the TGM1 gene

  20. We add a Korean case of genetically identified autosomal recessive congenital icthyosis, confirmed by the presence of compound heterozygous mutations in the TGM1 gene.

Mouse (Murine) Transglutaminase 1, Keratinocyte (TGM1) interaction partners

  1. results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.

  2. We also reveal that TGM1 modulates lung epithelial junction protein expression, suggesting a potentially protective role for hypoxia-induced TGM1 in pulmonary disease.

  3. Characterization of TGM2 and TGM1-TGM2 double knock-out mouse epidermis showed that unlike TGM2, TGM1 is indispensable for skin formation.

  4. that the up-regulation of molecular signatures for antimicrobial and innate defense responses is characteristic of skin with a transglutaminase 1 deficiency.

  5. Before the appearance of acute renal failure, which is apparent by morphological damage in the kidney and increases in blood creatinine levels, both the expression level and activity of TG1 rapidly increased mainly at the proximal tubule.

  6. This study investigated the in situ activities of transglutaminase-1 (skin-type) and transglutaminase-2 (tissue-type) using whole mouse sections of various embryonic developmental stages and neonates.

  7. The R142C mutation of transglutaminase 1 reduces the enzyme stability which is indispensable for development of the stratum corneum and skin barrier function and for postnatal survival of mice.

  8. Molecular deletion of transglutaminase 2 alone is insufficient to protect Mus musculus neurons from oxidative death, but inhibition of transglutaminase 1 and 2 is neuroprotective.

  9. These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 are expressed in vascular tissues

  10. Mouse models are used to study the role of tissue transglutaminase (tTG)in Huntington's disease; its critical that the level of expression in mouse forebrain be determined. tTG contributes to the majority of transglutaminase activity in mouse forebrain.

  11. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

  12. Tissue-specific stabilization of the cortical actin filament network by intracellular TGase1 activity may play a role in controlling barrier properties of endothelial monolayers

  13. transglutaminase 1

  14. Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation

  15. results demonstrate that TGase-1 plays an important role in regulation of renal epithelial cell proliferation through the JAK2-Stat-3 signaling pathway

TGM1 Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).

Gene names and symbols associated with TGM1

  • transglutaminase 1 (Tgm1) antibody
  • transglutaminase 1 (TGM1) antibody
  • transglutaminase 1, K polypeptide (Tgm1) antibody
  • 2310004J08Rik antibody
  • ARCI1 antibody
  • ICR2 antibody
  • KTG antibody
  • LI antibody
  • LI1 antibody
  • TGASE antibody
  • Tgase1 antibody
  • TGK antibody
  • TGM1 antibody

Protein level used designations for TGM1

TG(K) , TGK , TGase K , TGase-1 , epidermal TGase , protein-glutamine gamma-glutamyltransferase K , transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) , transglutaminase 1, K polypeptide , transglutaminase K , transglutaminase-1 , tranglutaminase 1 , Protein-glutamine gamma-glutamyltransferase K , K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase , transglutaminase 1 isoform , transglutaminase, keratinocyte , K polypeptide , TG K , TGase 1 , protein-glutamine-gamma-glutamyltransferase , transglutaminase type 1

GENE ID SPECIES
60335 Rattus norvegicus
407997 Bos taurus
403630 Canis lupus familiaris
100009118 Oryctolagus cuniculus
452814 Pan troglodytes
7051 Homo sapiens
21816 Mus musculus
100724400 Cavia porcellus
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