Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) ELISA Kits

The structure of the protein encoded by TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. Additionally we are shipping TRPA1 Antibodies (105) and TRPA1 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TRPA1 8989 O75762
Anti-Mouse TRPA1 TRPA1 277328 Q8BLA8
TRPA1 312896 Q6RI86
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Top TRPA1 ELISA Kits at antibodies-online.com

Showing 2 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Human 4.69 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details

Top referenced TRPA1 ELISA Kits

  1. Human TRPA1 ELISA Kit for Sandwich ELISA - ABIN421435 : Pereira, Mendes, Pereira, Muniz, Colares, Monteiro, Martins, Grisotto, Monteiro-Neto, Monteiro, Calixto, Brain, Fernandes: Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic Patients and Correlation with Pain and Disability. in Frontiers in pharmacology 2017 (PubMed)

More ELISA Kits for TRPA1 Interaction Partners

Zebrafish Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) interaction partners

  1. These findings provide novel insights into the structure-function relationship of TRPA1 and could lead to the development of more effective analgesics targeted to TRPA1.

  2. Zebrafish TRPA1a is specialized for chemical sensing, whereas zTRPA1b responds to thermal stimuli.

  3. Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function

  4. Larvae heterozygous for mutations in trpa1a respond to mustard oil to an extent similar to that of their wild-type siblings.

Fruit Fly (Drosophila melanogaster) Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) interaction partners

  1. bserved allyl isothiocyanate-evoked responses in both painless and dTRPA1 expressing neurons

  2. We show that signalling through the TrpA1 thermo-sensor is required for PMW, and that TrpA1 specifically impacts siesta onset, but not night sleep onset, in response to elevated temperatures. We identify two critical TrpA1-expressing circuits and show that both contact DN1p clock neurons, the output of which is also required for PMW.

  3. This review discusses the various roles that TRPA1 plays in temperature related behaviors with a main focus on the underlying neuronal circuits. [review]

  4. Characterization of TRPA1 and RyR demonstrates that Ca(2+) signaling is required for oxidative stress-induced activation of the Ras/MAPK pathway, which in turns drives intestinal stem cell proliferation.

  5. study shows that activity/rest rhythms are modulated in a temperature-dependent manner via signals from dTRPA1(SH)-GAL4 driven neurons. Taken together, these results emphasize the differential influence of thermoreceptors on rhythmic behavior in fruit flies in coordination with light inputs.

  6. Rh5 and Rh6 were required in trpA1-expressing neurons in the brain, ventral nerve cord, and body wall. Because Rh1 contributes to thermal selection in the comfortable range during the early to mid-third-instar stage, fine thermal discrimination depends on multiple rhodopsins.

  7. These findings demonstrate that Drosophila detects bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.

  8. Collectively, TRPA1 A isoform rapidly responds to natural sunlight intensities through its nucleophile sensitivity as a receptor of photochemically generated radicals, leading to an acute light-induced behavioral shift in Drosophila.

  9. H2O2-sensitive dTRPA1 isoforms promote avoidance of UV when adult Drosophila females are selecting sites for egg-laying.

  10. study concludes that the TRPA1 channel is not required for temperature synchronization but instead is required to repress activity during the warm part of the day

  11. Contribution of Drosophila TRPA1 to Metabolism.

  12. Citronellal can promote feeding deterrence of fruit flies through direct action on gustatory dTRPA1, revealing the first isoform-specific function for TRPA1(A).

  13. Recent work has uncovered the Transient Receptor Potential (TRP) channels TRPA1 mediating fly thermosensation.

  14. our results propose that the uracil/Duox pathway promotes bacteria expulsion from the gut through the HOCl-sensitive receptor, TRPA1(A)10b, thereby minimizing the chances that bacteria adapt to survive host defense systems.

  15. temperature sensitive regulation of afternoon peak activity under semi-natural conditions

  16. The mechanosensory channel, Piezo, has been identifieded in larval drosophila dorsal bipolar dendritic sensory neurons, with TRPA1 playing a subsidiary role.

  17. results suggest that specific isoforms of dTRPA1 can sense UV light via photochemical production of H2O2

  18. reported expression of TrpA1 in clock neurons is unlikely to be involved in generating the summer locomotor profile, suggesting that other TrpA1 neurons are responsible for the A component

  19. The activation of TRPA1-expressing neurons may differentially coordinate light/dark circadian entrainment, depending on the temperature.

  20. A 37-amino-acid-long intracellular region (encoded by a single exon) that is critical for dTRPA1 temperature responses.

Guinea Pig Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) interaction partners

  1. TRPA1 activation suppresses gastric accommodation by increasing gastric tone through cholinergic neuronal pathways.

Caenorhabditis elegans (C. elegans) Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) interaction partners

  1. Study reveals that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO.

  2. harsh touch specifically required the DEG/ENaC proteins MEC-10 and DEGT-1 (F25D1.4), which represent putative components of a harsh touch mechanotransduction complex; responses to cold required the TRPA-1 channel and were MEC-10 and DEGT-1 independent

  3. This study demonstrates that trpa-1 encodes an ion channel that can be activated in response to mechanical pressure and is required for mechanosensory neuron function.

Human Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) interaction partners

  1. TRPA1 polymorphisms may contribute to the heterogeneity of acute crisis pain in sickle cell disease.

  2. This study suggests that TRPA1 nociceptive responses in human skin strongly depend on intact capsaicin-sensitive, TRPV1 fibers.

  3. these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity.

  4. Our findings demonstrate that TRPA1 is a substrate of Cdk5 and that Cdk5 activity is also able to modulate TRPA1 agonist-induced calcium influx and chemo-nociceptive behavioral responses.

  5. TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba.

  6. LPS caused the increased functional expression of TRPA1, the activation of which involved in LPS-reduced inflammatory responses in primary human OA-FLS, and the inhibition of TRPA1 produces protective effect in LPS-induced arthritis.

  7. Blocking prolyl hydroxylation reveals TRPA1 sensitization to reactive oxygen species (ROS), which enables TRPA1 to convert ROS signalling into cold sensitivity.

  8. Data indicate a variant in the transient receptor potential ankyrin A1 channel (TRPA1) gene that selectively cosegregated with cramp-fasciculation syndrome (CFS) in a father-son pair.

  9. activation of TRPV1, but not TRPA1 mediates a calcium-dependent cell death.

  10. Peripheral neuronal equivalents (PNEs) exhibited morphological, molecular and functional characteristics of sensory neurons and expressed functional TRPA1 channels. PNE treatment with poly I:C caused similar transient heightened responses to TRPA1 activation compared to untreated cells.

  11. These findings provide novel insights into the structure-function relationship of TRPA1 and could lead to the development of more effective analgesics targeted to TRPA1.

  12. TRPA1 is involved in nitric oxide-mediated afferent sensory transmission in the clitoris while, in penile erectile tissue, a role for TRPA1 in cholinergic signaling might be assumed.

  13. data suggest that the most strictly conserved N-terminal ARs define the energetics of the TRPA1 channel gate and contribute to chemical-, calcium- and voltage-dependence.

  14. the heat sensing property of TRPA1 is conserved in mammalians, in which TRPA1 may contribute to sensing warmth and uncomfortable heat in addition to noxious cold.

  15. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.

  16. This study reveals a direct binding event and characterizes the role of TRPA1 ankyrin repeats in regulating FGFR2-driven oncogenic process; a mechanism that is hindered by miRNA-142-3p

  17. The results obtained with dorsal root ganglia neurons from transient receptor potential cation channel, subfamily A, member 1 channels (TRPA1)-/- mice, TRPM8-/- mice, and wild-type mice, using selective antagonists of TRPA1 and TRPM8 channels, as well as HEK293 cells stably expressing human, TRPA1, indicate that responses to cold, are mediated by TRPA1 channels.

  18. TRPA1 gene polymorphisms is associated with childhood asthma

  19. TRPM8, but not TRPA1, was detected in freshly isolated native human odontoblasts at the protein and mRNA levels, suggesting that odontoblasts play an important role in detecting external cold stimulation via TRPM8 in healthy condition.

  20. TRPV1 and TRPA1 also act as nociceptive sensors and potentiate the inflammatory process.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) interaction partners

  1. We conclude that cortical TRPA1 is critical in regulating cortical susceptibility to cortical spreading depression

  2. These data suggest that endothelial TRPA1 channels are sensors of hypoxia leading to vasodilation, thereby reducing ischemic damage.

  3. The present study determined that cold hypersensitivity in the early phase of DPN is mediated through the TRPA1 sensitization during diabetic vascular impairment in the STZ-induced diabetic mouse model.

  4. Study utilizing large-scale recessive genetics screen of randomly mutagenized mice using a highly robust 2-methyl-2-thiazoline-evoked innate fear assay found that the Trpa1-mediated chemosensory system, in addition to classical olfactory system, plays a central role in mediating predator odor-evoked innate fear/defensive behaviors in mice.

  5. Activation of Schwann cell TRPA1 evoked NADPH oxidase 1-dependent H2O2 release, and silencing or blocking Schwann cell NOX1 attenuated nerve injury-induced macrophage infiltration and oxidative stress.

  6. results demonstrate that carvacrol from plant oregano is a skin sensitizer or allergen; TRPV3 is involved in the initial phase and the sustained phase of pruritus, whereas TRPA1 likely contributes to the initial phase.

  7. Results indicated that inhibition of TRPA1 could prevent Dox-induced cardiomyocyte apoptosis in mice by inhibiting oxidative stress, inflammation, and ER stress.

  8. Blocking prolyl hydroxylation reveals TRPA1 sensitization to reactive oxygen species (ROS), which enables TRPA1 to convert ROS signalling into cold sensitivity.

  9. findings indicate that the initiation of the acute heat-evoked pain response in sensory nerve endings relies on three functionally redundant TRP channels, representing a fault-tolerant mechanism to avoid burn injury

  10. The stimulation of TRPA1 ion channels in CMs results in activation of a CaMKII-dependent signaling pathway resulting in modulation of intracellular Ca(2+) availability and handling leading to increases in CM contractile function. Cardiac TRPA1 ion channels may represent a novel therapeutic target for increasing the inotropic and lusitropic state of the heart.

  11. Mitochondrial modulation by all agents selectively increased cytosolic calcium in a subset of TRPA1/TRPV1-expressing (A1/V1+) neurons. There was a significant correlation between antimycin A-induced calcium responses and mitochondrial superoxide in wild-type 'responding' A1/V1+ neurons, which was eliminated in TRPA1-/- neurons, but not TRPV1-/- neurons

  12. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.

  13. Both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of allergic contact dermatitis.

  14. mmumiR449a may ameliorate neuropathic pain by decreasing the activity of the channel proteins TRPA1 and KCNMA1 and increasing the levels of TPTE.

  15. TRPA1, TRPV1 and mast cells play an indispensable role in the development of toluene-2,4-diisocyanate-elicited airway hyperreactivity

  16. The results obtained with dorsal root ganglia neurons from transient receptor potential cation channel, subfamily A, member 1 channels (TRPA1)-/- mice, TRPM8-/- mice, and wild-type mice, using selective antagonists of TRPA1 and TRPM8 channels, as well as HEK293 cells stably expressing human, TRPA1, indicate that responses to cold, are mediated by TRPA1 channels.

  17. This study demonstrated that botulinum neurotoxin A doenregulation of Trpa1 in the dorsal root ganglia in mice

  18. The TRPA1 channel may play a crucial role in neuronal development and oligodendrocyte maturation and be a potential regulator in emotion, cognition, learning and memory, and social behavior.

  19. Results identify AMPK as a previously unknown regulator of TRPA1 channels. AMPK modulation of TRPA1 could thus serve as an underlying mechanism and potential therapeutic molecular target in painful diabetic neuropathy.

  20. This study demonstrated that TRPA1 regulates mitogen-activated protein kinase pathways, as well as transcription factor c-Jun and a proapoptotic Bcl-2 family member (Bak) expression resulting in enhanced oligodendrocyte apoptosis.

TRPA1 Antigen Profile

Antigen Summary

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined\; however, studies indicate the function may involve a role in signal transduction and growth control.

Gene names and symbols associated with TRPA1

  • transient receptor potential cation channel, subfamily A, member 1a (trpa1a) antibody
  • Transient receptor potential cation channel A1 (TrpA1) antibody
  • transient receptor potential cation channel subfamily A member 1 (TRPA1) antibody
  • transient receptor potential A1 (LOC658860) antibody
  • transient receptor potential cation channel subfamily A member 1 (LOC694623) antibody
  • tryptophan synthase subunit alpha 1 (trpA1) antibody
  • transient receptor potential cation channel, subfamily A, member 1 (trpa1) antibody
  • transient receptor potential cation channel subfamily A member 1 (Trpa1) antibody
  • TRPA cation channel homolog (trpa-1) antibody
  • transient receptor potential cation channel, subfamily A, member 1 (Trpa1) antibody
  • Anktm1 antibody
  • CG5751 antibody
  • CG5761 antibody
  • CT18073 antibody
  • dANKTM1 antibody
  • Dmel\\CG5751 antibody
  • DmTRPA1 antibody
  • dTrpA antibody
  • dtrpA1 antibody
  • FEPS antibody
  • GLEAN_02449 antibody
  • TrpA antibody
  • trpA1 antibody

Protein level used designations for TRPA1

transient receptor potential cation channel subfamily A member 1 , CG5751-PG , CG5751-PH , CG5751-PI , CG5751-PJ , CG5751-PK , TrpA1-PG , TrpA1-PH , TrpA1-PI , TrpA1-PJ , TrpA1-PK , transient receptor potential A1 , transient receptor potential cation channel , transient-receptor-potential A1 , ankyrin-like protein 1 , transient receptor potential cation channel, subfamily A, member 1 , tryptophan synthase subunit alpha 1 , transient receptor potential cation channel subfamily A member 1-like , ankyrin-like with transmembrane domains 1 , ankyrin-like with transmembrane domains protein 1 , transformation-sensitive protein p120 , ANKTM1

GENE ID SPECIES
474351 Danio rerio
39015 Drosophila melanogaster
420180 Gallus gallus
464230 Pan troglodytes
486994 Canis lupus familiaris
505317 Bos taurus
658860 Tribolium castaneum
694623 Macaca mulatta
9895859 Achromobacter xylosoxidans A8
100152934 Sus scrofa
100158526 Xenopus (Silurana) tropicalis
100414472 Callithrix jacchus
100460642 Pongo abelii
100526649 Cavia porcellus
178118 Caenorhabditis elegans
8989 Homo sapiens
277328 Mus musculus
312896 Rattus norvegicus
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