Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) ELISA Kits

The protein encoded by TRPC6 forms a receptor-activated calcium channel in the cell membrane. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Antibodies (128) and Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TRPC6 7225 Q9Y210
Anti-Mouse TRPC6 TRPC6 22068 Q61143
Anti-Rat TRPC6 TRPC6 89823  
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Top Transient Receptor Potential Cation Channel, Subfamily C, Member 6 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.113 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days
$736.84
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More ELISA Kits for Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. TRPC6-mediated Ca(2+) influx plays a novel role in suppressing cytoprotective autophagy triggered by oxidative stress in PTC.

  2. Studied physiology of transient receptor potential cation channel subfamily C member 6 (TRPC6) in cultured human intervertebral disc cells exposed to simulated microgravity and to the TRPC channel inhibitor SKF-96365. Results found the simulated microgravity and/or TRPC channel inhibition led to reduced proliferation, increased senescence, and reduced TRPC6 expression.

  3. this study presents the structure of human TRPC6 homotetramer in complex with a newly identified high-affinity inhibitor BTDM solved by single-particle cryo-electron microscopy to 3.8 A resolution.

  4. In systemic lupus erythematous patients, TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner.

  5. TRPC6 expression is inversely correlated with cognitive performance of Alzheimer Disease (AD). TRPC6 in peripheral leucocytes may be a potential biomarker for the diagnosis of AD.

  6. Findings indicate that OLCT impairs the ability of breast cancer cells to proliferate and migrate via downregulation of TRPC6 channel expression while having no effect on the biology of non-tumoral breast cells.

  7. TRPC6 plays a pro-inflammatory role in the pathogenesis of CRSwNP via regulating Ca(2+) flow. Targeted therapy using TRPC6 inhibitor including SKF-96365 and TRPC6 small interfering RNA (siRNA) intranasally may alleviate the inflammatory reaction in CRSwNP.

  8. data demonstrate that the direct activation of TRPC6 channels contributes to CNCP-induced apoptotic cell death in HK-2cells

  9. Four novel TRPC6 variants were detected in Iranian focal segmental glomerulosclerosis children; in silico analysis showed that 2 variants (D130V and G162R) could be pathogenic.

  10. Authors found a specific reduction of TRPC6 mRNA levels in four AD sets and one MCI set. The median TRPC6 mRNA levels were lower in the following: (1) combined AD patients than in age-matched controls (0.78 vs 1.73, P<0.001); (2) mild-to-moderate AD patients than in age-matched controls (0.81 vs 1.73, P<0.001); and (3) MCI patients than in age-matched controls (0.76 vs 1.72, P<0.001).

  11. The results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex underlies attenuation of hyperglycemia-induced heart failure by TRPC6.

  12. The underlying mechanism forAT1-autoantibody induced podocyte damage might involve activation of the TRPC6 -calcium/calcineurin pathway.

  13. TRPC6 was upregulated in Diabetic nephropathy and could promote cell proliferation and inflammation by inhibiting the NFAT signaling pathway in tubular epithelial cells.

  14. Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors.

  15. Confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6. Phosphorylation of TRPC6 at serine 14 enhances channel conductance by boosting membrane expression of TRPC6, whereas protein stability and multimerization of TRPC6 are not altered.

  16. Reduction of TRPC6 activity, using either TRPC6 siRNA or a TRPC6 blocker, led to inhibition of hypoxia-induced autophagy, while enhancement of TRPC6 activity with a TRPC6 activator resulted in increased hypoxia-induced autophagy.

  17. axonal colocalization of TRPV4 and TRPC6 was found in the digital Meissner corpuscles

  18. Data suggest that TRPC6-mediated elevation of intracellular Ca2+ stimulates non-small cell lung cancer proliferation by promoting cell cycle progression.

  19. potential implications of transient receptor potential (TRP) channels in the pathogenesis of intestinal fibrosis, since they are known to act as cellular stress sensors/transducers affecting intracellular Ca(2+) homeostasis/dynamics, and are involved in a broad spectrum of cell pathophysiology including inflammation and tissue remodeling.

  20. Studies provide evidence that the TRPC6-mediated signaling pathway in kidney cells is under control of reactive oxygen species under both physiological and pathological conditions. [review]

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. results together suggested that miR-200b-3p inhibition reduced the currents of TRPC6, which led to the decrease of intracellular Ca(2+) concentration

  2. Trpc3 mRNA expression was significantly elevated in kidneys of Trpc6(-/-) mice underwent unilateral ureteral obstruction (UUO) while the levels did not change in kidneys of neither WT nor in New Zealand obese mice underwent UUO.

  3. This work indicates that TRPC6 exerts critical pathophysiological functions in placenta, and provides further evidence for a role of this channel in the homeostasis of cations like Zn and Fe.

  4. structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6

  5. These results suggest that TRPC6 may regulate GFR by modulating MC contractile function through multiple Ca(2+) signaling pathways.

  6. TRPC6-/- mice show less collagen production and normal lung function in pulmonary fibrosis compared to wild-type controls. TRPC6 expression is up-regulated in TGF-beta1-induced lung fibroblast-myofibroblast transdifferentiation.

  7. We conclude that TRPC6 channels of pancreatic stellate cells are major effector proteins in an autocrine stimulation pathway triggered by hypoxia.

  8. findings link Trpc6-mediated Ca2+ signaling and nitrosative stress in the redox pathobiology of Duchenne muscular dystrophy

  9. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.

  10. Administration of soluble klotho significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.

  11. In the present study, we have explored the hypothesis that TRPC3 and TRPC6 channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

  12. This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.

  13. ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin/NFAT signaling pathway.

  14. the mTORC2/Akt/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.

  15. AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII.

  16. transient receptor potential canonical 6 is an essential component of the slit diaphragm and is required for development of glomerulus

  17. TRPC3 and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  18. the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the alveolar macrophages also functions to shunt the transmembrane potential generated by proton pumping.

  19. Selectively activating endothelial TRPC6 rescues transendothelial migration

  20. MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. These findings suggest that lysoPC induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.

  2. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. Hyperforin (HF)-induced TRPC6 channel activation increased [Ca(2+)]i concentration, inhibited proliferation, and triggered apoptosis in primary neonatal pig glomerular mesangial cells. This apoptosis was not associated with oxidative stress. Activation stimulated NFATc1 nuclear translocation. HF also increased FasL level and caspase-8 activity.

  2. Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5, and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.

Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Antigen Profile

Antigen Summary

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Gene names and symbols associated with TRPC6

  • transient receptor potential cation channel subfamily C member 6 (TRPC6) antibody
  • transient receptor potential cation channel, subfamily C, member 6 (Trpc6) antibody
  • transient receptor potential cation channel, subfamily C, member 6a (trpc6a) antibody
  • transient receptor potential cation channel subfamily C member 6 (Trpc6) antibody
  • transient receptor potential cation channel subfamily C member 6 (trpc6) antibody
  • AV025995 antibody
  • bZ1P14.9 antibody
  • FSGS2 antibody
  • LLHWJM002 antibody
  • LLHWJM003 antibody
  • LLHWJM004 antibody
  • mtrp6 antibody
  • si:rp71-1p14.9 antibody
  • TRP-6 antibody
  • trp6 antibody
  • trpc6 antibody
  • Trrp6 antibody

Protein level used designations for TRPC6

TRP-6 , short transient receptor potential channel 6 , transient receptor protein 6 , calcium entry channel , transient receptor potential cation channel, subfamily C, member 6 , transient receptor potential channel subfamily C member 6 , short transient receptor potential channel 6-like

GENE ID SPECIES
7225 Homo sapiens
22068 Mus musculus
89823 Rattus norvegicus
407151 Bos taurus
418989 Gallus gallus
451503 Pan troglodytes
489435 Canis lupus familiaris
563989 Danio rerio
100061175 Equus caballus
100079408 Ornithorhynchus anatinus
100135637 Cavia porcellus
100271728 Sus scrofa
100347206 Oryctolagus cuniculus
100395510 Callithrix jacchus
100479387 Ailuropoda melanoleuca
100545253 Meleagris gallopavo
100554810 Anolis carolinensis
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