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Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TNP1 Antibodies (26) and TNP1 Kits (13) and many more products for this protein.
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We propose that SNPs on the TNP1 3'-UTR may help select semen quality trait in Chinese Holstein bulls in the dairy industry.
Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 (show RRP8 Proteins) and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.
frequency of the haplotype GCG (show GCG Proteins) (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level.
a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility
We found significantly lower levels of HILS1, TNP1, and TNP2 (show TNP2 Proteins) transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.
The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.
The presence of transition proteins (TP1 (show RPLP2 Proteins) and/or TP2 (show TERT Proteins)) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.
The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis.
Epididymal sperm from the Tnp1 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 (show PRM2 Proteins) processing with decreasing levels of transition proteins in mutant sperm.
JHDM2A (show KDM3A Proteins) directly binds to and controls the expression of transition nuclear protein 1 (show NUPR1 Proteins) (Tnp1) and protamine 1 (Prm1 (show PRM1 Proteins)) genes, the products of which are required for packaging and condensation of sperm chromatin
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990
transition protein 1 (during histone to protamine replacement)
, spermatid nuclear transition protein 1
, testis-specific basic protein
, Spermatid nuclear transition protein 1