anti-Translin (TSN) Antibodies

TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Additionally we are shipping Translin Proteins (11) and Translin Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TSN 7247 Q15631
TSN 22099 Q62348
TSN 60381  
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Top anti-Translin Antibodies at

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TSN Antibody Titration: 1.0 ug/ml Positive Control: 293T Whole Cell There is BioGPS gene expression data showing that TSN is expressed in HEK293T 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Translin staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Translin expression in MCF7 (A), HeLa (B), HepG2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using TSN Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TSN Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC (p), WB TSN Antibody (Center)  western blot analysis in HL-60,Jurkat,K562 cell line mouse spleen tissue lysates (35ug/lane).This demonstrates the TSN antibody detected the TSN protein (arrow). Fluorescent confocal image of Hela cell stained with TSN Antibody(Center).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with TSN primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min).TSN immunoreactivity is localized to Nucleus and Cytoplasm significantly. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.4 mL Log in to see 12 to 15 Days
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: Translin Antibody  - Staining of human testis shows strong cytoplasmic and nuclear positivity in cells in seminiferus ducts, Leydig cells showed moderate nuclear staining. 0.1 mL Log in to see 10 to 13 Days
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μL Log in to see 7 to 9 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days

TSN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,

, , , , , ,
Mouse (Murine)

Rat (Rattus)

More Antibodies against Translin Interaction Partners

Fruit Fly (Drosophila melanogaster) Translin (TSN) interaction partners

  1. Study describes the identification of translin (trsn), a highly conserved RNA/DNA binding protein (show CNBP Antibodies), as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.

  2. These studies establish that Trax (show TSNAX Antibodies) adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.

  3. Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (show AK3 Antibodies) to bind ssDNA and RNA targets

  4. A translin null mutant was generated and a trax (show TSNAX Antibodies) nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax (show TSNAX Antibodies).

  5. Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.

  6. Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.

  7. an RNAi regulator that we term C3PO (component 3 promoter of RISC (show SCPEP1 Antibodies)), a complex of Translin and Trax (show TSNAX Antibodies) was purified; C3PO is a Mg2 (show MCOLN1 Antibodies)+-dependent endoribonuclease that promotes RISC (show SCPEP1 Antibodies) activation by removing siRNA passenger strand cleavage products

Human Translin (TSN) interaction partners

  1. Translin and Trax (show TSNAX Antibodies) control telomere-associated transcript levels in human cells in a telomere-specific fashion.

  2. results indicate that UPF1 (show UPF1 Antibodies) can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (show DCLRE1C Antibodies) (TSN)-mediated miRNA decay.

  3. These findings indicate that miRNA depletion in dicer (show DICER1 Antibodies) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  4. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.

  5. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.

  6. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.

  7. Translin B3 motif, corresponding to TRAX (show TSNAX Antibodies) B3 residues, contributes towards its DNA binding activity.

  8. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX (show TSNAX Antibodies) subunits which activates RISC (show SCPEP1 Antibodies) by degrading the Ago2 (show EIF2C2 Antibodies)-nicked passenger strand of siRNA.

  9. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.

  10. study of reactivity of two -SH groups and stidu of proximity of Cys (show DNAJC5 Antibodies)-225 residues

Mouse (Murine) Translin (TSN) interaction partners

  1. These findings indicate that miRNA depletion in dicer (show DICER1 Antibodies) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (show BDNF Antibodies) mRNA can be mediated by both translin-dependent and -independent mechanisms.

  3. trax (show TSNAX Antibodies) acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.

  4. TB-RBP is involved in the posttranscriptional regulation of Gapds (show GAPDHS Antibodies) gene expression during spermiogenesis.

  5. TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression

  6. TB-RBP-mouse ribonucleoprotein complex transports a group of specific CREM (show CREM Antibodies)-regulated mRNAs in mammalian male postmeiotic germ cells.

  7. TB-RBP post-transcriptionally stabilizes TRAX (show TSNAX Antibodies) and both proteins are needed for normal cell proliferation

  8. subcellular locations of TB-RBP and TRAX (show TSNAX Antibodies) in male germ cells are modulated by the relative ratios of TRAX (show TSNAX Antibodies) and TB-RBP

  9. During a search for RNA-induced silencing complex (RISC (show SCPEP1 Antibodies)) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.

  10. These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis

Translin (TSN) Antigen Profile

Protein Summary

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Translin (TSN) Antibodies

  • translin L homeolog (tsn.L) antibody
  • translin (TSN) antibody
  • translin (trsn) antibody
  • haloacid dehalogenase (MMAH_RS03470) antibody
  • haloacid dehalogenase (TAGG_RS05275) antibody
  • Translin (Igag_0962) antibody
  • haloacid dehalogenase (MFER_RS03645) antibody
  • haloacid dehalogenase (DESMU_RS01315) antibody
  • translin (ARCVE_RS05265) antibody
  • haloacid dehalogenase (MZHIL_RS01310) antibody
  • translin (Tsn) antibody
  • 2610034C24Rik antibody
  • AU040286 antibody
  • BCLF-1 antibody
  • C3PO antibody
  • CG11761 antibody
  • Dmel\\CG11761 antibody
  • MGC52533 antibody
  • RCHF1 antibody
  • REHF-1 antibody
  • TB-RBP antibody
  • TBRBP antibody
  • TRSLN antibody
  • TSN antibody

Protein level used designations for anti-Translin (TSN) Antibodies

translin , CG11761-PA , testis-brain RNA binding protein , trsn-PA , Translin , component 3 of promoter of RISC , recombination hotspot associated factor , recombination hotspot-binding protein , testis brain-RNA binding protein , testis/brain RNA-binding protein , testis/brain-RNA-binding protein , translin protein

380118 Xenopus laevis
459586 Pan troglodytes
36110 Drosophila melanogaster
8982842 Methanohalophilus mahii DSM 5219
9166084 Thermosphaera aggregans DSM 11486
9716278 Ignisphaera aggregans DSM 17230
9962446 Methanothermus fervidus DSM 2088
10152942 Desulfurococcus mucosus DSM 2162
10394172 Archaeoglobus veneficus SNP6
10821850 Methanosalsum zhilinae DSM 4017
7247 Homo sapiens
22099 Mus musculus
60381 Rattus norvegicus
509943 Bos taurus
395955 Gallus gallus
100689410 Cricetulus griseus
100189807 Pongo abelii
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