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The protein encoded by TOMM22 is an integral membrane protein of the mitochondrial outer membrane. Additionally we are shipping Translocase of Outer Mitochondrial Membrane 22 Homolog (Yeast) Antibodies (20) and Translocase of Outer Mitochondrial Membrane 22 Homolog (Yeast) Proteins (7) and many more products for this protein.
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tomm22 has a role in hepatocyte cell death, affecting wnt and beta-catenin in liver regneration
The specificity and reversibility of hepatocyte ablation after temporary knockdown of Tomm22 provides an additional model to study liver regeneration, under conditions where most hepatocytes have died.
A directed proteomic approach discovered the novel interaction of BKCa with Tom22, a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (ANT).
Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells.
Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery.
Studies indicate that PUMA and TOMM22 as potential targets for miRNA-BART viral transcripts.
The interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane.
Levels of Tom22 in mitochondria accelerate the rate of Tom7 assembly into the mature TOM complex.
the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface
We have identified TOM22, a component of the translocase of the outer mitochondrial membrane (TOM), as a mitochondrial receptor of Bax.
Data demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.
mitochondrial import receptor Tom22
, mitochondrial import receptor subunit TOM22 homolog
, translocase of outer mitochondrial membrane 22 homolog (yeast)
, translocase of outer membrane 22 kDa subunit homolog
, Translocase of outer membrane 22 kDa subunit homolog